Abstract: The invention discloses a cell culture support which provides for the adhesion and culturing of one or more adhesive cells using a photoresist in which to provide a particular patterned design on a surface of the support. The patterned design is provided by the photoresist which is partially removed by photolithography during the making of the support which in turn imparts a striped, checkerboard or dotted pattern on the surface of the support. Further, the cell culture support is produced by pretreating the support surface with a reagent to provide hydrophobicity to the support surface. Also a reagent can be added to pretreat the support surface in order to facilitate adhesion at the photoresist prior to applying the photoresist into the cell culture support. Collagen is applied in the form of a solution, containing in addition thereto albumin and a crosslinking agent, in order to form a film. Collagen specifically affects the cell adhesion rate or the morphology of the cells to be adhered to the support.

Abstract: In a system and a method for observing a biological sample, a drive unit is connected to a solid state image sensor located to directly observe a biological sample. A record and display unit is connected to the drive unit for receiving, through the drive unit, observed image information picked up by the solid state image sensor. A control unit is connected to the drive unit and the record and display unit for intermittently or periodically putting the solid state image sensor into an operating condition. Thus, it is possible to effectively suppress or prevent the temperature elevation of the biological sample, which would otherwise be caused by the heat generated from the solid state image sensor. Accordingly, it is possible to continuously observe the growth or reproduction of a biological sample for a long time while giving no adverse influence to the growth or reproduction of the biological sample.

Abstract: A biological sample observation system and method of using a solid-state image sensor element and a holding member, wherein the holding member holds an observation target sample on an upper portion of a light-receiving portion of the solid-state area image sensor element, at a predetermined distance therefrom, and without an optical lens system between the holding member and the image sensor element.

Abstract: An enzyme electrode comprising an enzyme and a coenzyme immobilized in at least one layer is provided. This electrode has an outer membrane preventing the coenzyme from dissipation and so sensitivity and durability can be improved. In an inner membrane containing the enzyme and the coenzyme, a mediator of electron transfer may be added. The enzyme and the coenzyme may be separated in two layers, respectively, in the inner membrane to improve measurement sensitivity.