Patents by Inventor Shigui Li

Shigui Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combined chimeric antigen receptor targeting CD19 and CD20 and application thereof
    Publication number: 20240139243
    Abstract: The present invention provides a combined chimeric antigen receptor targeting CD19 and CD20 and application thereof. Specifically, the present invention provides a combined chimeric antigen receptor targeting CD19 and CD20, which comprises a scFv targeting CD19 and CD20, a hinge region, a transmembrane region, and an intracellular signaling domain. The present invention provides a nucleic acid molecule encoding the chimeric antigen receptor and a corresponding expression vector, a CAR-T cell, and applications thereof. The experimental results show that the chimeric antigen receptor provided by the present invention shows extremely high killing ability against tumor cells. The chimeric antigen receptor of the present invention targets CD19 and/or CD20 positive cells and can be used to treat CD19 and/or CD20 positive B-cell lymphoma, leukemia and other diseases.
    Type: Application
    Filed: March 14, 2023
    Publication date: May 2, 2024
    Inventors: Yihong YAO, Yanfeng LI, Yutian WEI, Shigui ZHU, Xin YAO, Jiaqi HUANG
  • Spatially-defined macrocyclic compounds useful for drug discovery
    Patent number: 8022252
    Abstract: Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
    Type: Grant
    Filed: August 25, 2008
    Date of Patent: September 20, 2011
    Assignee: Tranzyme Pharma Inc.
    Inventors: Pierre Deslongchamps, Yves Dory, Kamel Benakli, Éric Marsault, Luc Ouellet, Mahesh Ramaseshan, Martin Vezina, Daniel Fortin, Ruoxi Lan, Shigui Li, Gérald Villeneuve, Hamid R. Hoveyda, Sylvie Beaubien, Mark L. Peterson
  • SPATIALLY-DEFINED MACROCYCLIC COMPOUNDS USEFUL FOR DRUG DISCOVERY
    Publication number: 20090137817
    Abstract: Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
    Type: Application
    Filed: August 25, 2008
    Publication date: May 28, 2009
    Inventors: Pierre Deslongchamps, Yves Dory, Kamel Benakli, Eric Marsault, Luc Ouellet, Mahesh Ramaseshan, Martin Vezina, Daniel Fortin, Ruoxi Lan, Shigui Li, Gerald Villeneuve, Hamid R. Hoveyda, Sylvie Beaubien, Mark L. Peterson
  • Conformationally-controlled biologically active macrocyclic small molecules as motilin antagonists or ghrelin agonists
    Patent number: 7452862
    Abstract: Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: November 18, 2008
    Assignee: Tranzyme Pharma, Inc.
    Inventors: Pierre Deslongchamps, Yves Dory, Mark Peterson, Kamel Benakli, Eric Marsault, Luc Ouellet, Mahesh Ramaseshan, Martin Vézina, Daniel Fortin, Ruoxi Lan, Shigui Li, Gérald Villeneuve, Hamid Hoveyda, Sylvie Beaubien, Graeme L Fraser
  • Spatially-defined macrocyclic compounds useful for drug discovery
    Publication number: 20050137127
    Abstract: Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
    Type: Application
    Filed: August 2, 2004
    Publication date: June 23, 2005
    Applicant: TRANZYME PHARMA INC
    Inventors: Pierre Deslongchamps, Yves Dory, Mark Peterson, Kamel Benakli, Eric Marsault, Luc Ouellet, Mahesh Ramaseshan, Martin Vezina, Daniel Fortin, Ruoxi Lan, Shigui Li, Gerald Villeneuve, Hamid Hoveyda, Sylvie Beaubien