Patents by Inventor Shiguo Sun
Shiguo Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8962339Abstract: The present invention discloses a fluorescent probe compound which solved the problem of fluorescence quenching by Pd2+, and its preparation method and use as well. Excitation and emission wavelengths of the probe compound are in visible light region. The probe compound is highly sensitive and displays good selectivity for Pd2+ in near-neutral pH range. In detection of Pd2+ in 0-10 ppb level, fluorescence is evidently enhanced, and Pd2+ in the level as low as 5 nM can be detected. Fluorescence intensity is well linearly correlated to Pd2+ concentration. The probe compound can be used for detection of contaminating palladium and residual palladium in drug, soil, water sample and reactor.Type: GrantFiled: December 6, 2010Date of Patent: February 24, 2015Assignees: Dalian University of Technology, Dalian Chromas Bioscience Co., Ltd.Inventors: Xiaojun Peng, Jiangli Fan, Honglin Li, Jingyun Wang, Shiguo Sun
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Patent number: 8889887Abstract: A pentamethine cyanine fluorescent dye having the general formula I, a synthetic method and a use thereof are disclosed. In the general formula, X is CHO or CHCR3R4; R1 and R2 are independently selected from the group consisting of (CH2)nR7 and et al.; R3 and R4 are independently selected from the group consisting of CN, COOH and COOR16; R5, R6 and R7 are independently selected from the group consisting of H, SO3R10 and COOR11; R8 is H or C1-18 alkyl; R9 is H or CH3; R10 is N(R12R13R14R15); R11 is C1-18 alkyl; R12, R13, R14, R15 and R16 are independently selected from the group consisting of H, C1-18 alkyl, (CH2)mOR8 and (CHR9CH2O)pR8; Y? is halogen anion or OTs?; and n, m and p are integers of 0-18. The dye can be utilized to sensitively detect viscosity of micro-environment such as tissues and cells.Type: GrantFiled: January 31, 2011Date of Patent: November 18, 2014Assignees: Dalian University of Technology, Dalian Firstar Information Materials Co., Ltd.Inventors: Xiaojun Peng, Zhigang Yang, Yanxia He, Jingyun Wang, Jiangli Fan, Shiguo Sun, Fengling Song
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Patent number: 8735601Abstract: A pentamethine cyanine fluorescent dye with N-substituting at ?-position of conjugated chain is disclosed. The dye reacts with biosubstrate including protein, liposome and DNA, and shows excellent selectivity. It has good living cell membrane permeability and shows good selectivity in living cell staining In addition, the dye has good stability and low background fluorescence, and can be used together with other fluorescent dyes having consistent wavelengths for single-channel excitation and multi-channel detection. The dye can be used in the fields of protein labeling and detecting, fluorescence immunoassay and living cell selective imaging and the like.Type: GrantFiled: December 6, 2010Date of Patent: May 27, 2014Assignees: Dalian University of Technology, Dalian Chromas Bioscience Co., Ltd.Inventors: Xiaojun Peng, Zhigang Yang, Fengling Song, Yanxia He, Shiguo Sun, Jiangli Fan
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Patent number: 8734580Abstract: The present invention relates to compounds shown in the general formula (I) or (III), the salts thereof or their mixtures, as well as their preparation method and application. In the general formula (I), X1 is H or CO2H; X2 is OH or phenyl group with 0-2 sulfonic acid substituents, and the sulfonic acid substituents are located at random positions of a benzene ring; when X2 is OH, X1 is H; when X2 is phenyl group with 0-2 sulfonic acid substituents, X1 is H or CO2H; n is an integer of 0-2; and in the general formula (III), n and m are respectively an integer of 0-2. The compounds and the mixtures not only have improved light resistance, ozone resistance and water resistance, but also have excellent water solubility and long-term stability in ink-jet ink.Type: GrantFiled: June 17, 2013Date of Patent: May 27, 2014Assignees: Dalian University of Technology, Zhuhai Ninestar Management Co., Ltd.Inventors: Xiaojun Peng, Jinhe Wu, Zhi Long, Rong Zhang, Licheng Liaoning, Feng Wang, Shaolei Li, Jiangli Fan, Fengling Song, Shiguo Sun
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Patent number: 8664406Abstract: The disclosure provides fluorescence probe compounds of formula I, their preparation methods and applications. These compounds are useful in detecting mercury ions.Type: GrantFiled: December 3, 2010Date of Patent: March 4, 2014Assignees: Dalian University of Technology, Dalian Chromas Bioscience Co., Ltd.Inventors: Xiaojun Peng, Jiangli Fan, Jianjun Du, Jingyun Wang, Jianzhou Zhang, Shiguo Sun
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Patent number: 8591641Abstract: The invention is related to a weather-resistant dye and use thereof, which contains in molecules thereof not only chromophoric parent D, but also electron-accepting group Q which is linked with dye parent D through non-conjugated carbon link L to constitute D-L-Q dye molecule; the electron-accepting group Q has such a HOMO energy level that is lower than the HOMO energy level of the dye chromophoric parent D. The dye has sun-resistance and anti-ozone performances, which can be used as colorant in the ink, dope, lacquer, toner powder for laser printing, marker, paper, fabric, glass, porcelain or polymer.Type: GrantFiled: April 30, 2009Date of Patent: November 26, 2013Assignees: Dalian University of Technology, Ninestar Management Co., Ltd.Inventors: Xiaojun Peng, Jianzhou Zhang, Fan Jiangli, Shiguo Sun, Rong Zhang
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Publication number: 20130309715Abstract: A pentamethine cyanine fluorescent dye having the general formula I, a synthetic method and a use thereof are disclosed. In the general formula, X is CHO or CHCR3R4; R1 and R2 are independently selected from the group consisting of (CH2)nR2 and et al.; R3 and R4 are independently selected from the group consisting of CN, COOH and COOR16; R5, R6 and R7 are independently selected from the group consisting of H, SO3R10 and COOR11; R8 is H or C1-18 alkyl; R9 is H or CH3; R10 is N(R12R13R14R15); R11 is C1-18 alkyl; R12, R13, R14, R15 and R16 are independently selected from the group consisting of H, C1-18 alkyl, (CH2)mOR8 and (CHR9CH2O)pR8; Y? is halogen anion or OTs?; and n, m and p are integers of 0-18. The dye can be utilized to sensitively detect viscosity of micro-environment such as tissues and cells.Type: ApplicationFiled: January 31, 2011Publication date: November 21, 2013Inventors: Xiaojun Peng, Zhigang Yang, Yanxia He, Jingyun Wang, Jiangli Fan, Shiguo Sun, Fengling Song
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Publication number: 20130276667Abstract: The present invention relates to compounds shown in the general formula (I) or (III), the salts thereof or their mixtures, as well as their preparation method and application. In the general formula (I), X1 is H or CO2H; X2 is OH or phenyl group with 0-2 sulfonic acid substituents, and the sulfonic acid substituents are located at random positions of a benzene ring; when X2 is OH, X1 is H; when X2 is phenyl group with 0-2 sulfonic acid substituents, X1 is H or CO2H; n is an integer of 0-2; and in the general formula (III), n and m are respectively an integer of 0-2. The compounds and the mixtures not only have improved light resistance, ozone resistance and water resistance, but also have excellent water solubility and long-term stability in ink-jet ink.Type: ApplicationFiled: June 17, 2013Publication date: October 24, 2013Inventors: XIAOJUN PENG, JINHE WU, ZHI LONG, RONG ZHANG, LICHENG WANG, FENG WANG, SHAOLEI LI, JIANGLI FAN, FENGLING SONG, SHIGUO SUN
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Publication number: 20130137879Abstract: A fluorescence probe compound, its preparation method and use are provided.Type: ApplicationFiled: December 3, 2010Publication date: May 30, 2013Applicants: DALIAN CHRPMAS BIOSCIENCE CO., LTD., DALIAN UNIVERSITY OF TECHNOLOGYInventors: Xiaojun Peng, Jiangli Fan, Jianjun Du, Jingyun Wang, Jianzhou Zhang, Shiguo Sun
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Publication number: 20120296098Abstract: A pentamethine cyanine fluorescent dye with N-substituting at ?-position of conjugated chain is disclosed. The dye reacts with biosubstrate including protein, liposome and DNA, and shows excellent selectivity. It has good living cell membrane permeability and shows good selectivity in living cell staining In addition, the dye has good stability and low background fluorescence, and can be used together with other fluorescent dyes having consistent wavelengths for single-channel excitation and multi-channel detection. The dye can be used in the fields of protein labeling and detecting, fluorescence immunoassay and living cell selective imaging and the like.Type: ApplicationFiled: December 6, 2010Publication date: November 22, 2012Applicants: DALIAN CHROMAS BIOSCIENCE CO., LTD, DALIAN UNIVERSITY OF TECHNOLOGYInventors: Xiaojun Peng, Zhigang Yang, Fengling Song, Yanxia He, Shiguo Sun, Jiangli Fan
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Publication number: 20120288947Abstract: The present invention discloses a fluorescent probe compound which solved the problem of fluorescence quenching by Pd2+, and its preparation method and use as well. Excitation and emission wavelengths of the probe compound are in visible light region. The probe compound is highly sensitive and displays good selectivity for Pd2 in near-neutral pH range. In detection of Pd2 in 0-10 ppb level, fluorescence is evidently enhanced, and Pd2 in the level as low as 5 nM can be detected. Fluorescence intensity is well linearly correlated to Pd2 concentration. The probe compound can be used for detection of contaminating palladium and residual palladium in drug, soil, water sample and reactor.Type: ApplicationFiled: December 6, 2010Publication date: November 15, 2012Applicants: DALIAN CHROMAS BIOSCIENCE CO., LTD, DALIAN UNIVERSITY OF TECHNOLOGYInventors: Xiaojun Peng, Jiangli Fan, Honglin Li, Jingyun Wang, Shiguo Sun
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Patent number: 8298766Abstract: The present invention provides a category of cyanine dyes having the following general structural Formula I, wherein X is defined as C(CH3)2, O, S or Se; m is an integer from 1 to 18, R1 and R2 are each independently chosen from H, C1-18alkyl, OR7, C1-6alkyl-OR7 or halogen; R3 is pyrrolyl, imidazolyl, piperidinyl, piperazinyl, morpholinyl, guanidino, NHR5 or N(R6)2; R4 is C1-18alkyl, benzyl or (CH2)mR3; R5 is saturated and/or unsaturated, straight-chained and/or branched-chained C1-18alkyl, hydroxy alkyl, mercapto-alkyl, amino alkyl, acyl, phenyl, naphthyl or benzyl; R6 is a C2-18alkyl; R7 is H or a C1-18alkyl; Y? is an anion. The mentioned compounds can be applied to staining biological samples, to the fields of nucleic acids labeling, blood cell analysis, clinical diagnosis, immunological assays and etc.Type: GrantFiled: April 30, 2010Date of Patent: October 30, 2012Inventors: Xiaojun Peng, Tong Wu, Jiangli Fan, Shiguo Sun
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Patent number: 8133637Abstract: The fuel cells include electrode membrane assemblies having a nanoparticle catalyst supported on carbon nanorings. The carbon nanorings are formed from one or more carbon layers that form a wall that defines a generally annular nanostructure having a hole. The length of the nanoring is less than or about equal to the outer diameter thereof. The nanorings exhibit high surface area, high porosity, high graphitization, and/or facilitate mass transfer and electron transfer in fuel cell reactions.Type: GrantFiled: October 6, 2005Date of Patent: March 13, 2012Assignee: Headwaters Technology Innovation, LLCInventors: Gongquan Sun, Shuihua Tang, Shiguo Sun, Qin Xin, Changkun Liu, Bing Zhou
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Publication number: 20110262904Abstract: The present invention provides a category of cyanine dyes having the following general structural Formula I, wherein X is defined as C(CH3)2, O, S or Se; m is an integer from 1 to 18, R1 and R2 are each independently chosen from H, C1-18alkyl, OR7, C1-6alkyl-OR7 or halogen; R3 is pyrrolyl, imidazolyl, piperidinyl, piperazinyl, morpholinyl, guanidino, NHR5 or N(R6)2; R4 is C1-18alkyl, benzyl or (CH2)mR3; R5 is saturated and/or unsaturated, straight-chained and/or branched-chained C1-18alkyl, hydroxy alkyl, mercapto-alkyl, amino alkyl, acyl, phenyl, naphthyl or benzyl; R6 is a C2-18alkyl; R7 is H or a C1-18alkyl; Y? is an anion. The mentioned compounds can be applied to staining biological samples, to the fields of nucleic acids labeling, blood cell analysis, clinical diagnosis, immunological assays and etc.Type: ApplicationFiled: April 30, 2010Publication date: October 27, 2011Inventors: Xiaojun Peng, Tong Wu, Jiangli Fan, Shiguo Sun
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Publication number: 20110168053Abstract: The invention is related to a weather-resistant dye and use thereof, which contains in molecules thereof not only chromophoric parent D, but also electron-accepting group Q which is linked with dye parent D through non-conjugated carbon link L to constitute D-L-Q dye molecule; the electron-accepting group Q has such a HOMO energy level that is lower than the HOMO energy level of the dye chromophoric parent D. The dye has sun-resistance and anti-ozone performances, which can be used as colorant in the ink, dope, lacquer, toner powder for laser printing, marker, paper, fabric, glass, porcelain or polymer.Type: ApplicationFiled: May 13, 2009Publication date: July 14, 2011Inventors: Xiaojun Peng, Jianzhou Zhang, Jiangli Fan, Shiguo Sun, Rong Zhang
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Patent number: 7887771Abstract: Methods for manufacturing carbon nanostructures include 1) forming intermediate carbon nanostructures by polymerizing a carbon precursor in the presence of templating nanoparticles, 2) carbonizing the intermediate carbon nanostructures to form an intermediate composite nanostructure, and 3) removing the templating nanoparticles from the intermediate composite nanostructure to form carbon nanorings. The carbon nanorings manufactured using the foregoing steps have one or more carbon layers forming a wall that defines a generally annular nanostructure having a hole. The length of the nanoring is less than or about equal to the outer diameter thereof. The carbon nanostructures are well-suited for use as a fuel cell catalyst support. The carbon nanostructures exhibit high surface area, high porosity, high graphitization, and facilitate mass transfer and electron transfer in fuel cell reactions.Type: GrantFiled: October 5, 2006Date of Patent: February 15, 2011Assignees: Headwaters Technology Innovation, LLC, Dalian InstituteInventors: Gongquan Sun, Shuihua Tang, Shiguo Sun, Qin Xin, Changkun Liu, Bing Zhou
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Publication number: 20100135893Abstract: Methods for manufacturing carbon nanostructures include 1) forming intermediate carbon nanostructures by polymerizing a carbon precursor in the presence of templating nanoparticles, 2) carbonizing the intermediate carbon nanostructures to form an intermediate composite nanostructure, and 3) removing the templating nanoparticles from the intermediate composite nanostructure to form carbon nanorings. The carbon nanorings manufactured using the foregoing steps have one or more carbon layers forming a wall that defines a generally annular nanostructure having a hole. The length of the nanoring is less than or about equal to the outer diameter thereof. The carbon nanostructures are well-suited for use as a fuel cell catalyst support. The carbon nanostructures exhibit high surface area, high porosity, high graphitization, and facilitate mass transfer and electron transfer in fuel cell reactions.Type: ApplicationFiled: October 5, 2006Publication date: June 3, 2010Applicants: HEADWATERS NANOKINETIX, INC., DALIAN INSTITUTEInventors: Gongquan Sun, Shuihua Tang, Shiguo Sun, Qin Xin, Changkun Liu, Bing Zhou
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Patent number: 7598385Abstract: The present disclosure provides the asymmetric cyanine fluorescent dyes of formula I in which X, n, R1, R2, R3, R4, R5 and Y? are as defined in the specification. The present disclosure also provides conjugates of the fluorescent dyes, methods for preparation thereof, compositions comprising the fluorescent dyes, and methods for staining biological samples using the fluorescent dyes and compositions thereof.Type: GrantFiled: December 31, 2007Date of Patent: October 6, 2009Assignee: Shenzhen Mindray Biomedical Electronics Co., Ltd.Inventors: Xiaojun Peng, Tong Wu, Jiangli Fan, Shiguo Sun, Bingshuai Wang, Bing Xu, Jianhui Shao
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Publication number: 20090017441Abstract: The present disclosure provides the asymmetric cyanine fluorescent dyes of formula I in which X, n, R1, R2, R3, R4, R5 and Y? are as defined in the specification. The present disclosure also provides conjugates of the fluorescent dyes, methods for preparation thereof, compositions comprising the fluorescent dyes, and methods for staining biological samples using the fluorescent dyes and compositions thereof.Type: ApplicationFiled: December 31, 2007Publication date: January 15, 2009Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.Inventors: Xiaojun Peng, Tong Wu, Jiangli Fan, Shiguo Sun, Bingshuai Wang, Bing Xu, Jianhui Shao
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Publication number: 20070082255Abstract: The fuel cells include electrode membrane assemblies having a nanoparticle catalyst supported on carbon nanorings. The carbon nanorings are formed from one or more carbon layers that form a wall that defines a generally annular nanostructure having a hole. The length of the nanoring is less than or about equal to the outer diameter thereof. The nanorings exhibit high surface area, high porosity, high graphitization, and/or facilitate mass transfer and electron transfer in fuel cell reactions.Type: ApplicationFiled: October 6, 2005Publication date: April 12, 2007Inventors: Gongquan Sun, Shuihua Tang, Shiguo Sun, Qin Xin, Changkun Liu, Bing Zhou