Abstract: The disclosure relates to a compound of Formula (I), which acts as an allosteric inhibitor of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compound; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.

Abstract: The disclosure relates to compounds that act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.

Abstract: The disclosure relates to compounds that act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.

Abstract: The disclosure relates to a compound of Formula (I), which acts as an allosteric inhibitor of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compound; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.

Abstract: A light detecting device, a lighting module, and a manufacturing method for the same are provided. The lighting module includes a carrier, a light assembly having a first lighting unit and a second lighting unit, a lens assembly having a first lens and a second lens, and a casing surrounding the lens assembly. The first lighting unit emits a first beam having a first wavelength through the first lens to define a first view angle and the second lighting unit emits a second beam having a second wavelength through the second lens to define a second view angle. The first wavelength is smaller than the second wavelength, and the first view angle is greater than the second view angle.

Abstract: An optical sensor module includes a first frame set, a second frame set and a housing which partially covers the first frame set and the second frame set. The first frame set has a first chip-mounting frame and a first wiring frame. The first chip-mounting frame has a first chip-mounting section, and a first conductive lead. At least one first indentation is formed on the first chip-mounting section. The second frame set has a second chip-mounting frame and a second wiring frame. The second chip-mounting frame has a second chip-mounting section and a second conductive lead. At least one second indentation is formed on the second chip-mounting section.

Abstract: A light detecting device, a lighting module, and a manufacturing method for the same are provided. The lighting module includes a carrier, a light assembly having a first lighting unit and a second lighting unit, a lens assembly having a first lens and a second lens, and a casing surrounding the lens assembly. The first lighting unit emits a first beam having a first wavelength through the first lens to define a first view angle and the second lighting unit emits a second beam having a second wavelength through the second lens to define a second view angle. The first wavelength is smaller than the second wavelength, and the first view angle is greater than the second view angle.

Abstract: Disclosed are chemical entities which are compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, and Ra have the values described herein. Chemical entities according to the disclosure can be useful as inhibitors of ATG7. Further provided are pharmaceutical compositions comprising a chemical entity of the disclosure and methods of using the compositions in the treatment of cancer.

Abstract: An optical sensor module includes a first frame set, a second frame set and a housing which partially covers the first frame set and the second frame set. The first frame set has a first chip-mounting frame and a first wiring frame. The first chip-mounting frame has a first chip-mounting section, and a first conductive lead. At least one first indentation is formed on the first chip-mounting section. The second frame set has a second chip-mounting frame and a second wiring frame. The second chip-mounting frame has a second chip-mounting section and a second conductive lead. At least one second indentation is formed on the second chip-mounting section.

Abstract: The antiseptic wound dressing includes at least nanometer chitin, alkaline earth metal alginate, and an antiseptic material. The nanometer chitin is tubular shaped having diameter 10˜50 nm and length 20˜200 nm. The amount of the nanometer chitin is 0.1%˜5% to the alkaline earth metal alginate. The antiseptic wound dressing is manufactured by mixing nanometer chitin and alkaline metal alginate, further mixing with antiseptic material, conducting a wet spinning process to produce fibers, and conducting a non-woven cloth process to obtain the antiseptic wound dressing of the present invention. Therefore, the antiseptic wound dressing is capable of reducing the chance of would infection, and providing superior moisture retention and enhanced wet strength.

Abstract: The antiseptic wound dressing includes at least nanometer chitin, alkaline earth metal alginate, and an antiseptic material. The nanometer chitin is tubular shaped having diameter 10˜50 nm and length 20˜200 nm. The amount of the nanometer chitin is 0.1%˜5% to the alkaline earth metal alginate. The antiseptic wound dressing is manufactured by mixing nanometer chitin and alkaline earth metal alginate, further mixing with antiseptic material, conducting a wet spinning process to produce fibers, and conducting a non-woven cloth process to obtain the antiseptic wound dressing of the present invention. Therefore, the antiseptic wound dressing is capable of reducing the chance of would infection, and providing superior moisture retention and enhanced wet strength.

Abstract: Disclosed are chemical entities which are compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, and Ra have the values described herein. Chemical entities according to the disclosure can be useful as inhibitors of ATG7. Further provided are pharmaceutical compositions comprising a chemical entity of the disclosure and methods of using the compositions in the treatment of cancer.

Abstract: An apparatus and a method for driving a fluorescent lamp are provided. The apparatus submitted by the present invention includes an LC resonator and an automatic frequency tracing circuit. The LC resonator is used for receiving and converting a square signal to generate a sinusoidal driving signal for driving the fluorescent lamp. The automatic frequency tracing circuit is used for making a frequency of the sinusoidal driving signal automatically following a resonant frequency of the LC resonator according to a feedback signal related to the sinusoidal driving signal.

Abstract: A method for manufacturing a lighting device includes the steps of: preparing a substrate having at least one lighting chip, a frame for surrounding the lighting chip, and a cover body for covering one side of the frame; bonding the frame and the substrate so that the lighting chip is located within a region surrounded by the frame; and bonding the cover body and the frame so that the cover body and the frame cooperatively define a receptacle to cover the lighting chip. A bonding force between the cover body and the frame is configured to be smaller than a bonding force between the frame and the substrate so that when the cover body is separated from the frame, the bonding between the frame and the substrate is not destroyed.

Abstract: An apparatus for driving a fluorescent lamp is provided. The provided apparatus includes a power switching circuit, an LC resonator and an automatic frequency tracing circuit. The power switching circuit is coupled between an input voltage and a ground potential, and configured for switching and outputting the input voltage and the ground potential in response to two output signals with a phase difference of 180 degrees so as to generate a square signal. The LC resonator is configured for receiving and converting the square signal, so as to generate a sinusoidal driving signal for driving the fluorescent lamp. The automatic frequency tracing circuit is configured for generating and adjusting the two output signals according to a current feedback signal relating to the sinusoidal driving signal, so as to make the frequency of the sinusoidal driving signal automatically follow the resonant frequency of the LC resonator.

Abstract: An apparatus and a method for driving a fluorescent lamp are provided. The apparatus submitted by the present invention includes an LC resonator and an automatic frequency tracing circuit. The LC resonator is used for receiving and converting a square signal to generate a sinusoidal driving signal for driving the fluorescent lamp. The automatic frequency tracing circuit is used for making a frequency of the sinusoidal driving signal automatically following a resonant frequency of the LC resonator according to a feedback signal related to the sinusoidal driving signal.

Abstract: An apparatus and a method for driving a fluorescent lamp are provided. The apparatus submitted by the present invention includes a power switching circuit, an LC resonator and an automatic frequency tracing circuit. The power switching circuit is coupled between an input voltage and a ground potential, and is used for switching and outputting the input voltage and the ground potential in response to a ramp signal and a comparison voltage so as to generate a square signal. The LC resonator is used for receiving and converting the square signal to generate a sinusoidal driving signal for driving the fluorescent lamp. The automatic frequency tracing circuit is used for generating and adjusting the ramp signal according to a feedback signal related to the sinusoidal driving signal, so as to make a frequency of the sinusoidal driving signal automatically following a resonant frequency of the LC resonator.

Abstract: A fluorescent lamp device includes a frequency generator for generating a pulse signal, a driver circuit coupled to said frequency generator for generating at least one driving signal according to said pulse signal, a half bridge power switch unit coupled to the driver circuit, a resonant tank coupled to the half bridge power switch unit, and a fluorescent lamp coupled to the resonant tank.

Abstract: A light emitting diode (LED) module includes a lead frame having a number (N) of conducting arms spaced apart from each other, where N?3, and at least one LED die mounted on one of any two neighbor conducting arms. Any two neighbor conducting arms are electrically coupled each other.

Abstract: An apparatus for driving a fluorescent lamp is provided. The provided apparatus includes a power switching circuit, an LC resonator and an automatic frequency tracing circuit. The power switching circuit is coupled between an input voltage and a ground potential, and configured for switching and outputting the input voltage and the ground potential in response to two output signals with a phase difference of 180 degrees so as to generate a square signal. The LC resonator is configured for receiving and converting the square signal, so as to generate a sinusoidal driving signal for driving the fluorescent lamp. The automatic frequency tracing circuit is configured for generating and adjusting the two output signals according to a current feedback signal relating to the sinusoidal driving signal, so as to make the frequency of the sinusoidal driving signal automatically follow the resonant frequency of the LC resonator.