Patents by Inventor Shih H. Chu

Shih H. Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6-pyridyl substituted pyrimidine derivatives
    Patent number: 5278167
    Abstract: Novel 6-pyridyl substituted pyrimidine derivatives are disclosed for use as antiviral agents, particularly for the treatment of retroviral infections such as HIV infections and related disorders, as well as for use in anti-cancer therapies to improve the efficacy of anti-cancer therapeutics. These compounds and their pharmacologically acceptable salts operate to disrupt viral replication an exhibit lower cell toxicity, thereby providing more efficient agents for use alone or in conjunction with other chemical or biological agents to provide prolonged antiviral therapy. In addition, the compounds can be used to increase the efficacy of anti-cancer therapeutics including 5-fluropyrimidines such as 5-fluorouracil, thereby reducing the dosage requirement of the therapeutic in anti-cancer therapies so as to decrease toxic effects to the host.
    Type: Grant
    Filed: May 13, 1992
    Date of Patent: January 11, 1994
    Assignee: Brown University Research Foundation
    Inventors: Shih H. Chu, Yung C. Cheng, Bai C. Pan
  • Hydroxymethyl derivatives of 5-benzylacyclouridine and 5-benzoyloxybenzylacyclouridine and their use as potentiators for 5-fluoro-2'-deoxyuridine
    Patent number: 4613604
    Abstract: A compound of the Formula (I): ##STR1## where X is a benzyl group or a benzyloxybenzyl group and pharmaceutical preparations containing the same.
    Type: Grant
    Filed: July 31, 1985
    Date of Patent: September 23, 1986
    Assignee: Brown University Research Foundation
    Inventors: Shih H. Chu, Paul Calabresi, Ming Y. W. Chu, Mahmoud H. el Kouni, Fardos N. M. Naguib, Sungman Cha