Patents by Inventor Shih-Hon Li
Shih-Hon Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220387356Abstract: Provided herein are plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The disclosure includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.Type: ApplicationFiled: August 8, 2022Publication date: December 8, 2022Inventors: Daniel A. Lawrence, Cory Emal, Ashley Reinke, Shih-Hon Li
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Patent number: 11426368Abstract: Provided herein are plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The disclosure includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.Type: GrantFiled: July 27, 2018Date of Patent: August 30, 2022Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, EASTERN MICHIGAN UNIVERSITYInventors: Daniel A. Lawrence, Cory Emal, Ashley Reinke, Shih-Hon Li
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Publication number: 20170291893Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.Type: ApplicationFiled: June 27, 2017Publication date: October 12, 2017Inventors: Daniel A. Lawrence, Cory Emal, Ashley Reinke, Shih-Hon Li, Mark Warnock, Gregory Abernathy
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Patent number: 9718760Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.Type: GrantFiled: October 31, 2013Date of Patent: August 1, 2017Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, EASTERN MICHIGAN UNIVERSITYInventors: Daniel A. Lawrence, Cory Emal, Ashley Reinke, Shih-Hon Li, Mark Warnock, Gregory Abernathy
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Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism
Patent number: 9527878Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.Type: GrantFiled: August 4, 2015Date of Patent: December 27, 2016Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, EASTERN MICHIGAN UNIVERSITYInventors: Daniel A. Lawrence, Cory Emal, Jacqueline Cale, Enming Joe Su, Mark Warnock, Shih-Hon Li, Jeanne Ann Cupp -
PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF TO MODULATE LIPID METABOLISM
Publication number: 20160009748Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.Type: ApplicationFiled: August 4, 2015Publication date: January 14, 2016Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, EASTERN MICHIGAN UNIVERSITYInventors: Daniel A. Lawrence, Cory Emal, Jacqueline Cale, Enming Joe Su, Mark Warnock, Shih-Hon Li, Jeanne Ann Cupp -
Publication number: 20150315178Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.Type: ApplicationFiled: October 31, 2013Publication date: November 5, 2015Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, EASTERN MICHIGAN UNIVERSITYInventors: Daniel A. Lawrence, Cory Emal, Ashley Reinke, Shih-Hon Li, Mark Warnock, Gregory Abernathy
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Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism
Patent number: 9120744Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.Type: GrantFiled: November 23, 2009Date of Patent: September 1, 2015Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, EASTERN MICHIGAN UNIVERSITYInventors: Daniel A. Lawrence, Cory Emal, Jacqueline Cale, Enming J. Su, Mark Warnock, Shih-Hon Li, Jeanne A. Cupp -
Patent number: 8352263Abstract: The invention can recognize all languages and input words. It needs m unknown voices to represent m categories of known words with similar pronunciations. Words can be pronounced in any languages, dialects or accents. Each will be classified into one of m categories represented by its most similar unknown voice. When user pronounces a word, the invention finds its F most similar unknown voices. All words in F categories represented by F unknown voices will be arranged according to their pronunciation similarity and alphabetic letters. The pronounced word should be among the top words. Since we only find the F most similar unknown voices from m (=500) unknown voices and since the same word can be classified into several categories, our recognition method is stable for all users and can fast and accurately recognize all languages (English, Chinese and etc.) and input much more words without using samples.Type: GrantFiled: September 29, 2009Date of Patent: January 8, 2013Inventors: Tze-Fen Li, Tai-Jan Lee Li, Shih-Tzung Li, Shih-Hon Li, Li-Chuan Liao
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Publication number: 20120116764Abstract: A speech recognition method on all sentences in all languages is provided. A sentence can be a word, name or sentence. All sentences are represented by E×P=12×12 matrices of linear predict coding cepstra (LPCC) 1000 different voices are transformed into 1000 matrices of LPCC to represent 1000 databases. E×P matrices of known sentences after deletion of time intervals between two words are put into their closest databases. To classify an unknown sentence, use the distance to find its F closest databases and then from known sentences in its F databases, find a known sentence to be the unknown one. The invention needs no samples and can find a sentence in one second using Visual Basic. Any person without training can immediately and freely communicate with computer in any language. It can recognize up to 7200 English words, 500 sentences of any language and 500 Chinese words.Type: ApplicationFiled: November 9, 2010Publication date: May 10, 2012Inventors: Tze Fen Li, Tai-Jan Lee Li, Shih-Tzung Li, Shih-Hon Li, Li-Chuan Liao
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Patent number: 8160866Abstract: The present invention can recognize both English and Chinese at the same time. The most important skill is that the features of all English words (without samples) are entirely extracted from the features of Chinese syllables. The invention normalizes the signal waveforms of variable lengths for English words (Chinese syllables) such that the same words (syllables) can have the same features at the same time position. Hence the Bayesian classifier can recognize both the fast and slow utterance of sentences. The invention can improve the feature such that the speech recognition of the unknown English (Chinese) is guaranteed to be correct. Furthermore, since the invention can create the features of English words from the features of Chinese syllables, it can also create the features of other languages from the features of Chinese syllables and hence it can also recognize other languages, such as German, French, Japanese, Korean, Russian, etc.Type: GrantFiled: October 10, 2008Date of Patent: April 17, 2012Inventors: Tze Fen Li, Tai-Jan Lee Li, Shih-Tzung Li, Shih-Hon Li, Li-Chuan Liao
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Patent number: 8145483Abstract: The invention can recognize any several languages at the same time without using samples. The important skill is that features of known words in any language are extracted from unknown words or continuous voices. These unknown words represented by matrices are spread in the 144-dimensional space. The feature of a known word of any language represented by a matrix is simulated by the surrounding unknown words. The invention includes 12 elastic frames of equal length without filter and without overlap to normalize the signal waveform of variable length for a word, which has one to several syllables, into a 12×12 matrix as a feature of the word. The invention can improve the feature such that the speech recognition of an unknown sentence is correct. The invention can correctly recognize any languages without samples, such as English, Chinese, German, French, Japanese, Korean, Russian, Cantonese, Taiwanese, etc.Type: GrantFiled: August 5, 2009Date of Patent: March 27, 2012Inventors: Tze Fen Li, Tai-Jan Lee Li, Shih-Tzung Li, Shih-Hon Li, Li-Chuan Liao
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Publication number: 20110066434Abstract: The invention can recognize all languages and input words. It needs m unknown voices to represent m categories of known words with similar pronunciations. Words can be pronounced in any languages, dialects or accents. Each will be classified into one of m categories represented by its most similar unknown voice. When user pronounces a word, the invention finds its F most similar unknown voices. All words in F categories represented by F unknown voices will be arranged according to their pronunciation similarity and alphabetic letters. The pronounced word should be among the top words. Since we only find the F most similar unknown voices from m (=500) unknown voices and since the same word can be classified into several categories, our recognition method is stable for all users and can fast and accurately recognize all languages (English, Chinese and etc.) and input much more words without using samples.Type: ApplicationFiled: September 29, 2009Publication date: March 17, 2011Inventors: Tze-Fen LI, Tai-Jan Lee Li, Shih-Tzung Li, Shih-Hon Li, Li-Chuan Liao
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Publication number: 20110035216Abstract: The invention can recognize any several languages at the same time without using samples. The important skill is that features of known words in any language are extracted from unknown words or continuous voices. These unknown words represented by matrices are spread in the 144-dimensional space. The feature of a known word of any language represented by a matrix is simulated by the surrounding unknown words. The invention includes 12 elastic frames of equal length without filter and without overlap to normalize the signal waveform of variable length for a word, which has one to several syllables, into a 12×12 matrix as a feature of the word. The invention can improve the feature such that the speech recognition of an unknown sentence is correct. The invention can correctly recognize any languages without samples, such as English, Chinese, German, French, Japanese, Korean, Russian, Cantonese, Taiwanese, etc.Type: ApplicationFiled: August 5, 2009Publication date: February 10, 2011Inventors: Tze Fen LI, Tai-Jan Lee Li, Shih-Tzung Li, Shih-Hon Li, Li-Chuan Liao
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Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism
Publication number: 20100137194Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.Type: ApplicationFiled: November 23, 2009Publication date: June 3, 2010Applicants: EASTERN MICHIGAN UNIVERSITYInventors: Daniel A. Lawrence, Cory Emal, Jacqueline Cale, Enming J. Su, Mark Warnock, Shih-Hon Li, Jeanne A. Cupp -
Publication number: 20090265159Abstract: The present invention can recognize both English and Chinese at the same time. The most important skill is that the features of all English words (without samples) are entirely extracted from the features of Chinese syllables. The invention normalizes the signal waveforms of variable lengths for English words (Chinese syllables) such that the same words (syllables) can have the same features at the same time position. Hence the Bayesian classifier can recognize both the fast and slow utterance of sentences. The invention can improve the feature such that the speech recognition of the unknown English (Chinese) is guaranteed to be correct. Furthermore, since the invention can create the features of English words from the features of Chinese syllables, it can also create the features of other languages from the features of Chinese syllables and hence it can also recognize other languages, such as German, French, Japanese, Korean, Russian, etc.Type: ApplicationFiled: October 10, 2008Publication date: October 22, 2009Inventors: Tze-Fen LI, Tai-Jan Lee Li, Shih-Tzung Li, Shih-Hon Li, Li-Chuan Liao