Patents by Inventor Shih-Jen Liu
Shih-Jen Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240145697Abstract: A multi-layer cathode coating for positive electrode of a rechargeable electrochemical cell (or secondary cell) (such as a lithium-ion secondary battery) and a secondary battery including a cathode having a multi-layer cathode coating. Multi-layer cathode coatings containing blends of one or more cathode active materials in certain weight ratios thereof.Type: ApplicationFiled: October 27, 2022Publication date: May 2, 2024Applicant: SAFT AMERICAInventors: Xilin Chen, Frank Cao, Carine Margez Steinway, Kamen Nechev, Shih-Chieh Liao, Chia-Ming Chang, Dar-Jen Liu
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Publication number: 20240126002Abstract: A backlight module includes a light source, a first prism sheet disposed on the light source, and a light type adjustment sheet disposed on a side of the first prism sheet away from the light source and including a base and multiple light type adjustment structures. The multiple light type adjustment structures are disposed on the first surface of the base. Each light type adjustment structure has a first structure surface and a second structure surface connected to each other. The first structure surface of each light type adjustment structure and the first surface of the base form a first base angle therebetween, and the second structure surface of each light type adjustment structure and the first surface of the base form a second base angle therebetween. The angle of the first base angle is different from the angle of the second base angle.Type: ApplicationFiled: October 2, 2023Publication date: April 18, 2024Applicant: Coretronic CorporationInventors: Chih-Jen Tsang, Chung-Wei Huang, Shih-Yen Cheng, Jung-Wei Chang, Han-Yuan Liu, Chun-Wei Lee
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Publication number: 20240096781Abstract: A package structure including a semiconductor die, a redistribution circuit structure and an electronic device is provided. The semiconductor die is laterally encapsulated by an insulating encapsulation. The redistribution circuit structure is disposed on the semiconductor die and the insulating encapsulation. The redistribution circuit structure includes a colored dielectric layer, inter-dielectric layers and redistribution conductive layers embedded in the inter-dielectric layers. The electronic device is disposed over the colored dielectric layer and electrically connected to the redistribution circuit structure.Type: ApplicationFiled: March 20, 2023Publication date: March 21, 2024Applicant: Taiwan Semiconductor Manufacturing Company, Ltd.Inventors: Chun-Ti Lu, Hao-Yi Tsai, Chia-Hung Liu, Yu-Hsiang Hu, Hsiu-Jen Lin, Tzuan-Horng Liu, Chih-Hao Chang, Bo-Jiun Lin, Shih-Wei Chen, Hung-Chun Cho, Pei-Rong Ni, Hsin-Wei Huang, Zheng-Gang Tsai, Tai-You Liu, Po-Chang Shih, Yu-Ting Huang
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Publication number: 20240033350Abstract: The present disclosure relates to a vaccine composition, comprising a recombinant lipidated FLIPr (rLF), and the use thereof in enhancing humoral and cellular immune responses. The recombinant lipidated FLIPr of present invention may be used as a vaccine candidate that can induce anti-FLIPr responses to overcome FLIPr-mediated inhibition. And unexpectedly, the recombinant lipidated FLIPr may be used as an adjuvant that can enhance other vaccine immune responses, especially in subunit vaccines and inactivated virus vaccines.Type: ApplicationFiled: August 1, 2023Publication date: February 1, 2024Inventors: Hsin-Wei CHEN, Ming-Shu HSIEH, Shih-Jen LIU, Ching-Len LIAO
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Patent number: 11266728Abstract: Provided is a pharmaceutical composition, including an antigen fusion protein which includes an antigen and an antagonist of an Fc gamma receptor. Also provided is a method of enhancing immunogenicity of an antigen, including conjugating the antigen with an antagonist of an Fc gamma receptor to form an antigen fusion protein. Also provided is a method of enhancing an immune response to an antigen in a subject, including administering to the subject an effective amount of an antigen fusion protein which includes an antigen and an antagonist of an Fc gamma receptor. The present invention may be applied in the development of potent vaccines based on targeting vaccine antigens to antigen-presenting cells via binding to Fc gamma receptors.Type: GrantFiled: December 29, 2017Date of Patent: March 8, 2022Assignee: NATIONAL HEALTH RESEARCH INSTITUTESInventors: Hsin-Wei Chen, Chih-Hsiang Leng, Shih-Jen Liu
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Patent number: 10995126Abstract: Described herein are an immunogenic peptide containing the sequence of CLDSLGQWN (SEQ ID NO:2) and a method of using the peptide for treating cancer.Type: GrantFiled: May 3, 2017Date of Patent: May 4, 2021Assignees: National Health Research Institutes, Academia SinicaInventors: Shih-Jen Liu, Hsin-Wei Chen, Steve Roffler, Ming-Hsi Huang, Chih-Hsiang Leng
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Publication number: 20190321456Abstract: Provided is a pharmaceutical composition, including an antigen fusion protein which includes an antigen and an antagonist of an Fc gamma receptor. Also provided is a method of enhancing immunogenicity of an antigen, including conjugating the antigen with an antagonist of an Fc gamma receptor to form an antigen fusion protein. Also provided is a method of enhancing an immune response to an antigen in a subject, including administering to the subject an effective amount of an antigen fusion protein which includes an antigen and an antagonist of an Fc gamma receptor. The present invention may be applied in the development of potent vaccines based on targeting vaccine antigens to antigen-presenting cells via binding to Fc gamma receptors.Type: ApplicationFiled: December 29, 2017Publication date: October 24, 2019Inventors: Hsin-Wei CHEN, Chih-Hsiang LENG, Shih-Jen LIU
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Publication number: 20190135883Abstract: Described herein are an immunogenic peptide containing the sequence of CLDSLGQWN (SEQ ID NO:2) and a method of using the peptide for treating cancer.Type: ApplicationFiled: May 3, 2017Publication date: May 9, 2019Inventors: Shih-Jen Liu, Hsin-Wei Chen, Steve Roffler, Ming-Hsi Huang, Chih-Hsiang Leng
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Patent number: 10172945Abstract: A composition in a water-in-oil-in-water (W/O/W) emulsion is disclosed. The composition comprises: (a) a continuous aqueous phase, comprising H2O; (b) an oil phase or an oil shell, dispersed in the continuous aqueous phase; and (c) a hydrophilic polymer, stabilizing an interface between the continuous aqueous phase and the oil phase or the oil shell to form the water-in-oil-in-water (W/O/W) emulsion. The oil phase or the oil shell comprises: (i) oil; (ii) an internal aqueous phase, dispersed within the oil or the oil shell; and (iii) a lipophilic sorbitan-polyester conjugate, stabilizing an interface between the oil and the inner aqueous phase to form a water-in-oil (W/O) emulsion. The lipophilic sorbitan-polyester conjugate comprises: (1) sorbitan; and (2) poly(lactide-co-?-caprolactone) or polylactic acid (polylactide), conjugated to the sorbitan.Type: GrantFiled: January 12, 2016Date of Patent: January 8, 2019Assignee: NATIONAL HEALTH RESEARCH INSTITUTESInventors: Ming-Hsi Huang, Chiung-Yi Huang, Pele Choi-Sing Chong, Chih-Hsiang Leng, Shih-Jen Liu, Hsin-Wei Chen
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Publication number: 20180008713Abstract: A composition in a water-in-oil-in-water (W/O/W) emulsion is disclosed. The composition comprises: (a) a continuous aqueous phase, comprising H2O; (b) an oil phase or an oil shell, dispersed in the continuous aqueous phase; and (c) a hydrophilic polymer, stabilizing an interface between the continuous aqueous phase and the oil phase or the oil shell to form the water-in-oil-in-water (W/O/W) emulsion. The oil phase or the oil shell comprises: (i) oil; (ii) an internal aqueous phase, dispersed within the oil or the oil shell; and (iii) a lipophilic sorbitan-polyester conjugate, stabilizing an interface between the oil and the inner aqueous phase to form a water-in-oil (W/O) emulsion. The lipophilic sorbitan-polyester conjugate comprises: (1) sorbitan; and (2) poly(lactide-co-?-caprolactone) or polylactic acid (polylactide), conjugated to the sorbitan.Type: ApplicationFiled: January 12, 2016Publication date: January 11, 2018Inventors: Ming-Hsi HUANG, Chiung-Yi HUANG, Pele Choi-Sing CHONG, Chih-Hsiang LENG, Shih-Jen LIU, Hsin-Wei CHEN
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Patent number: 8771990Abstract: A method of producing a recombinant lipidated polypeptide in E. coli. The method includes providing an E. coli host cell adapted to express a recombinant lipidated polypeptide; and culturing the E. coli host cell in a minimal medium under conditions that allow expression of the polypeptide in lipidated form.Type: GrantFiled: November 15, 2011Date of Patent: July 8, 2014Assignee: National Health Research InstitutesInventors: Chih-Hsiang Leng, Chi-Ling Tseng, Shih-Jen Liu, Hsin-Wei Chen, Pele Choi-Sing Chong
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Patent number: 8658767Abstract: This invention relates to, inter alia, an isolated lipidated polypeptide including a lipid moiety at the N-terminus and a plurality of epitopes, and methods of making and using the polypeptide.Type: GrantFiled: November 15, 2011Date of Patent: February 25, 2014Assignee: National Health Research InstitutesInventors: Chih-Hsiang Leng, Chi-Ling Tseng, Hsueh-Hung Liu, Shih-Jen Liu, Hsin-Wei Chen, Pele Choi-Sing Chong
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Patent number: 8658176Abstract: Disclosed are polypeptides and fusion proteins. Also disclosed are related immunotherapeutic compositions and methods.Type: GrantFiled: June 22, 2010Date of Patent: February 25, 2014Assignee: National Health Research InstitutesInventors: Chih-Hsiang Leng, Hsin-Wei Chen, Shih-Jen Liu, Pele Choi-Sing Chong
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Publication number: 20130251748Abstract: The present invention relates a method for vaccinating a mammal to produce an antibody against Enterobacteriaceae infection caused by Klebsiella pneumoniae, Salmonella typhi, or E. coli in central nervous system and/or peripheral blood circulation, which comprises administering an effective amount of an OmpK36/homologues or its derivatives to the mammal.Type: ApplicationFiled: July 10, 2012Publication date: September 26, 2013Applicant: NATIONAL DEFENSE MEDICAL CENTERInventors: Leung-Kei Siu, Feng-Yee Chang, Yung-Chung Lin, Chang-Phone Fung, Yip-Mei Liu, Jiun-Han Chen, Yu-Kuo Tsai, Pele Choi-Sing Chong, Chih-Hsiang Leng, Shih-Jen Liu, Hsin-Wei Chen
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Patent number: 8466259Abstract: Disclosed are lipopeptides or lipoproteins, related compositions, and related methods.Type: GrantFiled: February 9, 2010Date of Patent: June 18, 2013Assignee: National Health Research InstitutesInventors: Shih-Jen Liu, Hsueh-Hung Liu, Chih-Hsiang Leng, Hsin-Wei Chen, Yan Chak Kwok, Pele Choi-Sing Chong
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Patent number: 8465756Abstract: An immunopeptide containing a T cell epitope from the tumor associated antigen L6 (TAL6) and a nucleic acid encoding the immunopeptide are described herein. The immunopeptide or its encoding nucleic acid can be used as a component of an immune composition for enhancing immune response against cancer cells that express TAL6.Type: GrantFiled: July 29, 2010Date of Patent: June 18, 2013Assignee: National Health Research InstitutesInventors: Shih-Jen Liu, Hsin-Wei Chen, Pele Choi-Sing Chong, Chih-Hsiang Leng
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Patent number: 8444993Abstract: A method for enhancing a body's response to an immunogen is disclosed. The method comprises immunizing a subject in need thereof a vaccine composition in a water-in-oil (W/O/W) emulsion that comprises (a) an antigen; and (b) an adjuvant composition in a W/O/W emulsion. The adjuvant composition comprises: (i) a continuous aqueous phase comprising H2O; (ii) an oil phase comprising oil dispersed in the continuous aqueous phase, comprising an internal aqueous phase comprising H2O, being dispersed in the oil phase; and a physiologically acceptable lipophilic emulsifier selected from the group consisting of mannide monooleate and sorbitan esters, stabilizing the interface between the inner aqueous phase and the oil phase to form a water-in-oil (W/O) emulsion; and (iii) poly(ethylene glycol)-block-poly(lactide-co-?-caprolactone), stabilizing the interface between the oil phase and the continuous aqueous phase.Type: GrantFiled: September 5, 2012Date of Patent: May 21, 2013Assignee: National Health Research InstitutesInventors: Ming-Hsi Huang, Pele Choi-Sing Chong, Chih-Hsiang Leng, Shih-Jen Liu, Hsin-Wei Chen
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Patent number: 8426163Abstract: Production of a lipidated protein in an E. coli strain adapted to membrane protein expression.Type: GrantFiled: December 5, 2008Date of Patent: April 23, 2013Assignee: National Health Research InstitutesInventors: Chih-Hsiang Leng, Shih-Jen Liu, Hsin-Wei Chen, Pele Choi-Sing Chong
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Publication number: 20120328654Abstract: A method for enhancing a body's response to an immunogen is disclosed. The method comprises immunizing a subject in need thereof a vaccine composition in a water-in-oil (W/O/W) emulsion that comprises (a) an antigen; and (b) an adjuvant composition in a W/O/W emulsion. The adjuvant composition comprises: (i) a continuous aqueous phase comprising H2O; (ii) an oil phase comprising oil dispersed in the continuous aqueous phase, comprising an internal aqueous phase comprising H2O, being dispersed in the oil phase; and a physiologically acceptable lipophilic emulsifier selected from the group consisting of mannide monooleate and sorbitan esters, stabilizing the interface between the inner aqueous phase and the oil phase to form a water-in-oil (W/O) emulsion; and (iii) poly(ethylene glycol)-block-poly(lactide-co-?-caprolactone), stabilizing the interface between the oil phase and the continuous aqueous phase.Type: ApplicationFiled: September 5, 2012Publication date: December 27, 2012Applicant: NATIONAL HEALTH RESEARCH INSTITUTESInventors: Ming-Hsi HUANG, Pele Choi-Sing CHONG, Chih-Hsiang LENG, Shih-Jen LIU, Hsin-Wei CHEN
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Patent number: 8287880Abstract: Disclosed are immunogenic composition, fusion proteins, and related methods for inducing immune response to dengue virus infection.Type: GrantFiled: May 26, 2010Date of Patent: October 16, 2012Assignee: National Health Research InstitutesInventors: Hsin-Wei Chen, Chih-Hsiang Leng, Shih-Jen Liu, Pele Choi-Sing Chong