Abstract: The present invention provides a method for rescuing retinal degeneration comprising administering a subject in need thereof a pharmaceutical composition comprising an inhibitor of DUSP6 via ERK 1/2 autophagy pathway.

Abstract: The present invention is directed to an integrated conceptual strategy for a gene delivery system, using the combination of nanoparticles, CRISPR-Cas9, and the HITI strategy to deliver CRISPR-Cas9 and achieve effective genome editing; wherein the advanced nanoparticles to overcome the limited packaging size of AAV-based vehicles.

Abstract: Compositions, systems and methods for delivering CRISPR/Cas9-based genome editing system and a donor protein to a cell.

Abstract: An integrated device includes a laser ranging module, a dual-branched fiber bundle, a beam splitter, and an image receiving module. The laser ranging module includes a light source, an optical receiver and a computing unit. The fiber bundle is disposed between the laser ranging module and the beam splitter. A target reflects a measuring beam emitted by the light source to form a reflected beam. The beam splitter splits the reflected beam into a first reflected beam and a second reflected beam. The first reflected beam is transmitted to the optical receiver through the fiber bundle to generate a measurement signal. The computing unit receives the measurement signal to calculate a distance between the target and the fiber bundle. The image receiving module is disposed on the optical path of the second reflected beam to receive the second reflected beam and displays the image of the target.

Abstract: An integrated device includes a laser ranging module, a dual-branched fiber bundle, a beam splitter, and an image receiving module. The laser ranging module includes a light source, an optical receiver and a computing unit. The fiber bundle is disposed between the laser ranging module and the beam splitter. A target reflects a measuring beam emitted by the light source to form a reflected beam. The beam splitter splits the reflected beam into a first reflected beam and a second reflected beam. The first reflected beam is transmitted to the optical receiver through the fiber bundle to generate a measurement signal. The computing unit receives the measurement signal to calculate a distance between the target and the fiber bundle. The image receiving module is disposed on the optical path of the second reflected beam to receive the second reflected beam and displays the image of the target.

Abstract: A flexible optical measuring device comprises an optical distance measuring module, an optical fiber adapter and an optical coupling module. The optical distance measuring module comprises a light source, an optical receiver and a computing unit. The optical fiber adapter is disposed and connected between the optical distance measuring module and the optical coupling module. The optical coupling module comprises a first optical fiber, a two-in-one optical coupler, a detector and a second optical fiber. A measuring beam is emitted from the light source and reaches the detector. The measuring beam then passes through the detector to the object and forms a reflected beam which is reflected back to the detector, then enters the second optical fiber and passes through the optical receiver and the optical receiver outputs a measurement signal. The computing unit calculates the distance between the object and a terminal of the detector accordingly.

Abstract: A flexible optical measuring device comprises an optical distance measuring module, an optical fiber adapter and an optical coupling module. The optical distance measuring module comprises a light source, an optical receiver and a computing unit. The optical fiber adapter is disposed and connected between the optical distance measuring module and the optical coupling module. The optical coupling module comprises a first optical fiber, a two-in-one optical coupler, a detector and a second optical fiber. A measuring beam is emitted from the light source and reaches the detector. The measuring beam then passes through the detector to the object and forms a reflected beam which is reflected back to the detector, then enters the second optical fiber and passes through the optical receiver and the optical receiver outputs a measurement signal. The computing unit calculates the distance between the object and a terminal of the detector accordingly.

Abstract: An array near-field high optical scattering material detection method is disclosed, which comprises steps of irradiating an input light onto a high scattering material to generate a diffuse reflection, a diffusion, and a transmission within the high scattering material; reading out an optical energy over different positions on the high scattering material, respectively; forming a two dimensional light intensity distribution data image according to the optical energy over different positions on the high scattering material, respectively; and analyzing an internal composition variation of the high scattering material according to the two dimensional light intensity distribution data image to obtain the internal composition data of the high scattering material.

Abstract: An image-based refractive index measuring system comprises an optical device and an electronic device. The optical device is used to guiding an external light which is passed through an analyte. The electronic device comprises an image capture module, an image analyze module and a display module. The image capture module generates a first image by capturing the external light source. The image analyze module connects to the image capture module to receive the first image, and analyzes the first image in order to generate an analytical result comprising the refractive index of the analyte. The display module connects to the image analyze module to receive and display the analytical result.

Abstract: An image-based diopter measuring system comprises an optical device and an electronic device. The optical device is used to guiding an external light which is passed through an analyte. The electronic device comprises an image capture module, an image analyze module and a display module. The image capture module generates a first image by capturing the external light source. The image analyze module connects to the image capture module to receive the first image, and analyzes the first image in order to generate an analytical result comprising the diopter of the analyte. The display module connects to the image analyze module to receive and display the analytical result.

Abstract: A handheld facial analyzing device based on estimating the characteristics of human facial skin includes an image capturing unit, a memory unit, a display unit, a processing unit, and a user interface. The processing unit receives an instruction from the user interface corresponding to a position on the image data displayed by the display unit and generates a facial analysis result having information on skin roughness and wrinkles from the gray-scale image data corresponding to the image data in accordance to the position in the instruction.