Patents by Inventor Shih-Lan Hsu

Shih-Lan Hsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10400289
    Abstract: The present invention provides a method for detecting a target nucleic acid that comprises a step of providing a sample; contacting the sample with a polynucleotide probe comprising a first sequence and a second sequence complementary to the target nucleic acid; and adding a nuclease for cleaving the second sequence of the polynucleotide probe. The present invention further provides a polynucleotide probe for detecting a target nucleic acid that comprises a first sequence and a second sequence complementary to the target nucleic acid. Moreover, the present invention provides a kit for detecting a target nucleic acid.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: September 3, 2019
    Assignee: National Taiwan University
    Inventors: Ja-An A. Ho, Amily F. Jou, Yen-Chuan Ou, Shian-Shiang Wang, Itamar Willner, Shih-Lan Hsu
  • Publication number: 20180148797
    Abstract: The present invention provides a method for detecting a target nucleic acid that comprises a step of providing a sample; contacting the sample with a polynucleotide probe comprising a first sequence and a second sequence complementary to the target nucleic acid; and adding a nuclease for cleaving the second sequence of the polynucleotide probe. The present invention further provides a polynucleotide probe for detecting a target nucleic acid that comprises a first sequence and a second sequence complementary to the target nucleic acid. Moreover, the present invention provides a kit for detecting a target nucleic acid.
    Type: Application
    Filed: January 12, 2018
    Publication date: May 31, 2018
    Inventors: Ja-An A. Ho, Amily F. Jou, Yen-Chuan Ou, Shian-Shiang Wang, Itamar Willner, Shih-Lan Hsu
  • Patent number: 9902997
    Abstract: The present invention provides a method for detecting a target nucleic acid that comprises a step of providing a sample; contacting the sample with a polynucleotide probe comprising a first sequence and a second sequence complementary to the target nucleic acid; and adding a nuclease for cleaving the second sequence of the polynucleotide probe. The present invention further provides a polynucleotide probe for detecting a target nucleic acid that comprises a first sequence and a second sequence complementary to the target nucleic acid. Moreover, the present invention provides a kit for detecting a target nucleic acid.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: February 27, 2018
    Assignee: National Taiwan University
    Inventors: Ja-An A. Ho, Amily F. Jou, Yen-Chuan Ou, Shian-Shiang Wang, Itamar Willner, Shih-Lan Hsu
  • Publication number: 20160130653
    Abstract: The present invention provides a method for detecting a target nucleic acid that comprises a step of providing a sample; contacting the sample with a polynucleotide probe comprising a first sequence and a second sequence complementary to the target nucleic acid; and adding a nuclease for cleaving the second sequence of the polynucleotide probe. The present invention further provides a polynucleotide probe for detecting a target nucleic acid that comprises a first sequence and a second sequence complementary to the target nucleic acid. Moreover, the present invention provides a kit for detecting a target nucleic acid.
    Type: Application
    Filed: November 11, 2014
    Publication date: May 12, 2016
    Inventors: Ja-An A. Ho, Amily F. Jou, Yen-Chuan Ou, Shian-Shiang Wang, Itamar Willner, Shih-Lan Hsu
  • Patent number: 8361441
    Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: January 29, 2013
    Assignee: Taipei Medical University
    Inventors: Yi-Yuan Yang, Hsueh-Hsia Wu, Sy-Jye Leu, Neng-Yao Shih, I-Jen Huang, Wen-Shyang Hsieh, Ko-Jiunn Liu, Shih-Yi Huang, Yung-Luen Shih, Chi-Hsin Lee, Yuan-Soon Ho, Shih-Lan Hsu
  • Patent number: 7972785
    Abstract: The present invention provides a method for detecting liver fibrotic injury, including fibrosis and/or cirrhosis, by assaying biological samples for differential expression of at least one gene encoding a protein chosen from SEQ ID NO: 1-SEQ ID NO: 63 and human orthologs thereof, wherein differential expression of at least one gene suggests the presence of liver fibrosis or cirrhosis. The invention also provides a kit containing nucleic acid probes or antibodies for detecting liver fibrosis and/or cirrhosis by assaying the differential expression of proteins encoded by SEQ ID NO: 1-SEQ ID NO: 63 and human orthologs thereof.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: July 5, 2011
    Assignees: Industrial Technology Research Institute (ITRI), National Health Research Institutes (NHRI)
    Inventors: Hui-Chu Hsieh, Tzu-Ling Tseng, Li-Jen Su, Chi-Ying Huang, Shih-Lan Hsu
  • Patent number: 7807139
    Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: October 5, 2010
    Assignee: Taipei Medical University
    Inventors: Yi-Yuan Yang, Hsueh-Hsia Wu, Sy-Jye Leu, Neng-Yao Shih, I-Jen Huang, Ching-Yu Lin, Wen-Shyang Hsieh, Ko-Jiunn Liu, Shih-Yi Huang, Yueh-Lun Lee, Chi-Hsin Lee, Yuan-Soon Ho, Shih-Lan Hsu
  • Publication number: 20100087373
    Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.
    Type: Application
    Filed: September 29, 2009
    Publication date: April 8, 2010
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Yi-Yuan Yang, Hsueh-Hsia Wu, Sy-Jye Leu, Neng-Yao Shih, I-Jen Huang, Ching-Yu Lin, Wen-Shyang Hsieh, Ko-Jiunn Liu, Shih-Yi Huang, Yung-Luen Shih, Chi-Hsin Lee, Yuan-Soon Ho, Shih-Lan Hsu
  • Publication number: 20090232852
    Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection caused by klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.
    Type: Application
    Filed: January 23, 2009
    Publication date: September 17, 2009
    Applicant: Taipei Medical University
    Inventors: Yi-Yuan Yang, Hsueh-Hsia Wu, Sy-Jye Leu, Neng-Yao Shih, I-Jen Huang, Ching-Yu Lin, Wen-Shyang Hsieh, Ko-Jiunn Liu, Shih-Yi Huang, Yueh-Lun Lee, Chi-Hsin Lee, Yuan-Soon Ho, Shih-Lan Hsu
  • Patent number: 7588776
    Abstract: A pharmaceutical composition containing a water-soluble fraction of Graptopetalum and its use in treating a liver disease or condition, such as inflammation, steatosis, and fibrosis.
    Type: Grant
    Filed: February 27, 2008
    Date of Patent: September 15, 2009
    Inventor: Shih-Lan Hsu
  • Publication number: 20080160112
    Abstract: The present invention relates to a pharmaceutical composition containing a water-soluble fraction of Graptopetalum and its use in treating a liver disease or condition, such as inflammation, steatosis, and fibrosis.
    Type: Application
    Filed: February 27, 2008
    Publication date: July 3, 2008
    Inventor: Shih-Lan Hsu
  • Patent number: 7364758
    Abstract: The present invention relates to compositions comprising Graptopetalum and uses thereof Graptopetalum can protect animals from liver diseases and medical conditions, such as inflammation, steatosis, and fibrosis. In particular, Graptopetalum inhibits proliferation of activated hepatic stellate cells, which play a pivotal role in liver fibrosis. Graptopetalum also has anti-fibrosis activities as well as inhibits proliferation of lung fibroblasts. Therefore, in addition to being a prophylactic and therapeutic agent for the liver, Graptopetalum is useful against fibrosis or inflammation of tissues or organs other than the liver, in particular lung, kidney, and bladder. Other plants in the family of Crassulaceae, particularly Echeveria, have similar effects as Graptopetalum.
    Type: Grant
    Filed: August 31, 2004
    Date of Patent: April 29, 2008
    Inventor: Shih-Lan Hsu
  • Publication number: 20070184476
    Abstract: The present invention provides a method for detecting liver fibrotic injury, including fibrosis and/or cirrhosis, by assaying biological samples for differential expression of at least one gene encoding a protein chosen from SEQ ID NO: 1-SEQ ID NO: 63 and human orthologs thereof, wherein differential expression of at least one gene suggests the presence of liver fibrosis or cirrhosis. The invention also provides a kit containing nucleic acid probes or antibodies for detecting liver fibrosis and/or cirrhosis by assaying the differential expression of proteins encoded by SEQ ID NO: 1-SEQ ID NO: 63 and human orthologs thereof.
    Type: Application
    Filed: January 23, 2007
    Publication date: August 9, 2007
    Inventors: Hui-Chu Hsieh, Tzu-Ling Tseng, Li-Jen Su, Chi-Ying Huang, Shih-Lan Hsu
  • Publication number: 20060045925
    Abstract: The present invention relates to compositions comprising Graptopetalum and uses thereof Graptopetalum can protect animals from liver diseases and medical conditions, such as inflammation, steatosis, and fibrosis. In particular, Graptopetalum inhibits proliferation of activated hepatic stellate cells, which play a pivotal role in liver fibrosis. Graptopetalum also has anti-fibrosis activities as well as inhibits proliferation of lung fibroblasts. Therefore, in addition to being a prophylactic and therapeutic agent for the liver, Graptopetalum is useful against fibrosis or inflammation of tissues or organs other than the liver, in particular lung, kidney, and bladder. Other plants in the family of Crassulaceae, particularly Echeveria, have similar effects as Graptopetalum.
    Type: Application
    Filed: August 31, 2004
    Publication date: March 2, 2006
    Inventor: Shih-Lan Hsu
  • Publication number: 20040076618
    Abstract: The present invention provides a placental preparation, its preparation method and medical uses in cancer treatments. Said placental preparation is a fraction having molecular weight less than 3 kDa obtained from a postpartum placenta of a mammal including human. The placental preparation according to the present invention has an excellent selective cytotoxicity toward tumor cells and in turn an excellent antitumor activity without any undesired side effect, and is thus very useful in cancer treatment.
    Type: Application
    Filed: April 2, 2003
    Publication date: April 22, 2004
    Applicant: Ru-Chein YU
    Inventors: Shuang-Lin Lee, Shih-Lan Hsu