Abstract: A topical formulation comprising (a) a therapeutically effective amount of tofacitinib; (b) at least one solvent; and (c) optionally one or more other pharmaceutically acceptable excipients is provided. Also provided is a method for treating and/or preventing autoimmune diseases in a subject administering said topical formulation.

Abstract: Provided is a manufacturing method of circuit board, including a first substrate, a second substrate, a third substrate, a fourth substrate, multiple conductive structures, and a conductive via structure. The third substrate has an opening and includes a first dielectric layer. The opening penetrates the third substrate, and the first dielectric layer fills the opening. Multiple conductive structures are formed so that the first substrate, the second substrate, the third substrate, and the fourth substrate are electrically connected through the conductive structures to define a ground path. A conductive via structure is formed to penetrate the first substrate, the second substrate, the first dielectric layer of the third substrate, and the fourth substrate. The conductive via structure is electrically connected to the first substrate and the fourth substrate to define a signal path, and the ground path surrounds the signal path.

Abstract: A method of making micro-holes on a metal plate includes: (A) feeding a metal plate on a workbench forward to extend beyond a shearing edge; (B) locating a punching head at a first position, and keeping a working space between the punching head and the workbench; (C) exerting a shearing force towards the workbench by the punching head; (D) bending the metal plate by the shearing force, and forming a plurality of spot-shaped cavities arranged in a row on a second surface; (E) bearing a shearing force on the first surface of the metal plate to form a linear groove; (F) deforming the metal plate by the shearing force to cause the spot-shaped cavities arranged in a row to communicate with the linear groove to form micro-holes; (G) the punching head returning to the first position and moving a working distance to a second position; (H) feeding the metal plate again; (I) the punching head repeating the above steps at the second position; (J) the punching head returning to the second position and then moving back to

Abstract: An electro-magnetic wave filtering and impeding board is made of metal and includes a first side and a second side. The first side has multiple linear slots and the second side includes multiple concaved geometric holes which communicate with the linear slots. The electro-magnetic waves are impeded by the metallic material and weakened when passing through the linear slots and the geometric holes so as to impede the electro-magnetic waves.

Abstract: A method of making micro-holes on a metal plate includes: (A) feeding a metal plate on a workbench forward to extend beyond a shearing edge; (B) locating a punching head at a first position, and keeping a working space between the punching head and the workbench; (C) exerting a shearing force towards the workbench by the punching head; (D) bending the metal plate by the shearing force, and forming a plurality of spot-shaped cavities arranged in a row on a second surface; (E) bearing a shearing force on the first surface of the metal plate to form a linear groove; (F) deforming the metal plate by the shearing force to cause the spot-shaped cavities arranged in a row to communicate with the linear groove to form micro-holes; (G) the punching head returning to the first position and moving a working distance to a second position; (H) feeding the metal plate again; (I) the punching head repeating the above steps at the second position; (J) the punching head returning to the second position and then moving back to