Patents by Inventor Shih-Ya CHEN

Shih-Ya CHEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11555871
    Abstract: A method of detecting a biological sample includes the following steps. A magnetic sensor chip is provided, wherein the magnetic sensor chip includes a substrate and a magnetic sensing layer located on the substrate. Probes are connected to the magnetic sensor chip. A sample solution containing biological samples labeled with a first marker is provided on the magnetic sensor chip, so that the biological samples labeled with the first marker are hybridized with the probes. Magnetic beads labeled with a second marker are provided on the magnetic sensor chip, so that the magnetic beads labeled with the second marker are bound onto the biological samples labeled with the first marker. A signal sensed by the magnetic sensing layer is detected by a magnetic sensor.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: January 17, 2023
    Assignee: Industrial Technology Research Institute
    Inventors: Cheng-Tai Chen, Shih-Ya Chen, Yi-Chen Liu, Ching-Fang Lu, Chia-Chen Chang, Erh-Fang Lee
  • Publication number: 20210199733
    Abstract: A method of detecting a biological sample includes the following steps. A magnetic sensor chip is provided, wherein the magnetic sensor chip includes a substrate and a magnetic sensing layer located on the substrate. Probes are connected to the magnetic sensor chip. A sample solution containing biological samples labeled with a first marker is provided on the magnetic sensor chip, so that the biological samples labeled with the first marker are hybridized with the probes. Magnetic beads labeled with a second marker are provided on the magnetic sensor chip, so that the magnetic beads labeled with the second marker are bound onto the biological samples labeled with the first marker. A signal sensed by the magnetic sensing layer is detected by a magnetic sensor.
    Type: Application
    Filed: December 29, 2020
    Publication date: July 1, 2021
    Applicant: Industrial Technology Research Institute
    Inventors: Cheng-Tai Chen, Shih-Ya Chen, Yi-Chen Liu, Ching-Fang Lu, Chia-Chen Chang, Erh-Fang Lee
  • Publication number: 20170183737
    Abstract: The disclosure provides a method for estimating a risk for a subject suffering from hepatocellular carcinoma, including: (a) determining methylation levels of APC gene, COX2 gene, RASSF1A gene and micro RNA-203 gene in a sample of a subject, respectively; (b) calculating a predicted score according to the methylation levels of the APC gene, COX2 gene, RASSF1A gene and micro RNA-203 gene; and (c) estimating a risk level for the subject suffering from hepatocellular carcinoma according to the predicted score.
    Type: Application
    Filed: December 30, 2015
    Publication date: June 29, 2017
    Applicant: Industrial Technology Research Institute
    Inventors: Chang-Yi LU, Chia-Jui YEN, Shih-Ya CHEN, Chia-Ju LIN, Yi-Chen LIU, Pu-Yeh KAN, Hui-Ling PENG, Wan-Chi CHANG, Chao-Yun TSAO
  • Publication number: 20120184453
    Abstract: Methods for determining the likelihood of colorectal cancer (CRC) recurrence in a subject that involve measuring the expression level of two or more micro ribonucleic acids (miRNAs) in a biological sample comprising CRC tumor cells from said subject and using the normalized, measured expression levels to determine the likelihood of colorectal cancer recurrence for said subject. In the methods, the normalized expression levels of specific miRNAs are weighted by their contribution to CRC recurrence to calculate the likelihood of CRC recurrence. Kits for measuring the expression level of specific miRNAs that can be used in determining the likelihood of CRC recurrence are also provided.
    Type: Application
    Filed: January 11, 2012
    Publication date: July 19, 2012
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Ting-Huei WANG, Yen-Peng LI, Pei-Fen KUO, Shih-Ya CHEN, Chia-Ju LIN, Jenq-Chang LEE, Angelina Huai-Lo LEE