Patents by Inventor Shihe LIANG

Shihe LIANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical composition containing alkynyl compound and preparation method and application thereof
    Patent number: 12097195
    Abstract: The present invention relates to a pharmaceutical composition containing alkynyl compound, a preparation method thereof and its application. The present invention discloses a pharmaceutical composition comprising an active pharmaceutical ingredient and an available pharmaceutical excipient; The active pharmaceutical ingredient is 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide, or its pharmaceutical acceptable salt; The available pharmaceutical excipients includes diluents and lubricants. The pharmaceutical composition can effectively improve the bioavailability of the alkynyl compound, has good dissolution and stability, and improve the drug safety.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: September 24, 2024
    Assignees: Ascentage Pharma (Suzhou) Co., Ltd., Ascentage Pharma Group Corp Limited, Guangzhou Healthquest Pharma Co., Ltd.
    Inventors: Yanqiong Lin, Jianfeng Wen, Feng Xu, Jiaan Huang, Shixiong Li, Xiaoling He, Shihe Liang
  • Pharmaceutical composition containing alkynyl compound and preparation method and application thereof
    Publication number: 20220296587
    Abstract: The present invention relates to a pharmaceutical composition containing alkynyl compound, a preparation method thereof and its application. The present invention discloses a pharmaceutical composition comprising an active pharmaceutical ingredient and an available pharmaceutical excipient; The active pharmaceutical ingredient is 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide, or its pharmaceutical acceptable salt; The available pharmaceutical excipients includes diluents and lubricants. The pharmaceutical composition can effectively improve the bioavailability of the alkynyl compound, has good dissolution and stability, and improve the drug safety.
    Type: Application
    Filed: December 9, 2019
    Publication date: September 22, 2022
    Inventors: Yanqiong LIN, Jianfeng WEN, Feng XU, Jiaan HUANG, Shixiong LI, Xiaoling HE, Shihe LIANG