Patents by Inventor Shiho Chiba

Shiho Chiba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECOMBINANT INFLUENZA VIRUSES WITH STABILIZED HA FOR REPLICATION IN EGGS
    Publication number: 20240076632
    Abstract: Modified influenza virus neuraminidases are described herein that improve viral replication, thus improving the yield of vaccine viruses. Expression of such modified neuraminidases by influenza virus may also stabilize co-expressed hemagglutinins so that the hemagglutinins do not undergo mutation or decrease the need for HA binding to cells.
    Type: Application
    Filed: September 5, 2023
    Publication date: March 7, 2024
    Inventors: Yoshihiro Kawaoka, Shinya Yamada, Shiho Chiba
  • Recombinant influenza viruses with stabilized HA for replication in eggs
    Patent number: 11807872
    Abstract: Modified influenza virus neuraminidases are described herein that improve viral replication, thus improving the yield of vaccine viruses. Expression of such modified neuraminidases by influenza virus may also stabilize co-expressed hemagglutinins so that the hemagglutinins do not undergo mutation or decrease the need for HA binding to cells.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: November 7, 2023
    Assignees: Wisconsin Alumni Research Foundation (WARF), The University of Tokyo
    Inventors: Yoshihiro Kawaoka, Shinya Yamada, Shiho Chiba
  • COMPOSITIONS COMPRISING COMPLEXES DISPLAYING ANTIGENS AND METHODS OF USING THE COMPOSITIONS
    Publication number: 20230321217
    Abstract: A nanoparticle that displays a coronavirus spike protein or a portion thereof on its surface, and methods of making and using the nanoparticle, are provided.
    Type: Application
    Filed: September 28, 2022
    Publication date: October 12, 2023
    Inventors: Yoshihiro Kawaoka, Peter J. Halfmann, Ravi Kane, Steven J. Frey, Gabriele Neumann, Shiho Chiba, Ana Luisa Stringari de Castro, Kathryn E. Loeffler
  • RECOMBINANT INFLUENZA VIRUSES WITH STABILIZED HA FOR REPLICATION IN EGGS
    Publication number: 20220202927
    Abstract: Modified influenza virus neuraminidases are described herein that improve viral replication, thus improving the yield of vaccine viruses. Expression of such modified. neuraminidases by influenza virus may also stabilize co-expressed hemagglutinins so that the hemagglutinins do not undergo mutation.
    Type: Application
    Filed: December 9, 2021
    Publication date: June 30, 2022
    Inventors: Yoshihiro Kawaoka, Shinya Yamada, Shiho Chiba
  • Recombinant influenza viruses with stabilized HA for replication in eggs
    Patent number: 11197926
    Abstract: Modified influenza virus neuraminidases are described herein that improve viral replication, thus improving the yield of vaccine viruses. Expression of such modified neuraminidases by influenza virus may also stabilize co-expressed hemagglutinins so that the hemagglutinins do not undergo mutation.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: December 14, 2021
    Assignees: Wisconsin Alumni Research Foundation (WARF), The University of Tokyo
    Inventors: Yoshihiro Kawaoka, Shinya Yamada, Shiho Chiba
  • RECOMBINANT INFLUENZA VIRUSES WITH STABILIZED HA FOR REPLICATION IN EGGS
    Publication number: 20210102178
    Abstract: Modified influenza virus neuraminidases are described herein that improve viral replication, thus improving the yield of vaccine viruses. Expression of such modified neuraminidases by influenza virus may also stabilize co-expressed hemagglutinins so that the hemagglutinins do not undergo mutation or decrease the need for HA binding to cells.
    Type: Application
    Filed: August 27, 2020
    Publication date: April 8, 2021
    Inventors: Yoshihiro Kawaoka, Shinya Yamada, Shiho Chiba
  • RECOMBINANT INFLUENZA VIRUSES WITH STABILIZED HA FOR REPLICATION IN EGGS
    Publication number: 20190167781
    Abstract: Modified influenza virus neuraminidases are described herein that improve viral replication, thus improving the yield of vaccine viruses. Expression of such modified neuraminidases by influenza virus may also stabilize co-expressed hemagglutinins so that the hemagglutinins do not undergo mutation.
    Type: Application
    Filed: October 25, 2018
    Publication date: June 6, 2019
    Inventors: Yoshihiro Kawaoka, Shinya Yamada, Shiho Chiba