Abstract: The present invention relates to multi-substituted pyridone derivatives and therapeutic use thereof. In particular, the present invention relates to a compound of formula (I), a preparation method therefor, a pharmaceutical composition comprising the same, as well as use thereof as a tyrosine kinase inhibitor, in particular, use thereof in treating a disease associated with tyrosine kinase activity. Each substituent in the formula (I) is defined as in the specification.

Abstract: The present disclosure discloses a microwave flash evaporation process and apparatus and uses thereof. A microwave flash evaporation process, wherein the process makes integration of those technologies for liquid spraying, liquid droplet flash evaporation, microwave enhancement, vacuum steam discharge, and simulation and optimization of multi-mode resonant cavity, wherein through the coupling effect of the microwave, by means of one stage microwave flash evaporation, the effect normally achieved by multi-effect evaporation and flash evaporation is obtained and a liquid droplet micro-system with microwave energy transfer in situ is formed so as to prevent a circulation pump and a steam heat exchange system from being corroded under high temperature and high pressure, and prevent scaling on a heat exchanger, and improve evaporation efficiency.

Abstract: The present disclosure discloses a microwave flash evaporation process and apparatus and uses thereof. A microwave flash evaporation process, wherein the process makes integration of those technologies for liquid spraying, liquid droplet flash evaporation, microwave enhancement, vacuum steam discharge, and simulation and optimization of multi-mode resonant cavity, wherein through the coupling effect of the microwave, by means of one stage microwave flash evaporation, the effect normally achieved by multi-effect evaporation and flash evaporation is obtained and a liquid droplet micro-system with microwave energy transfer in situ is formed so as to prevent a circulation pump and a steam heat exchange system from being corroded under high temperature and high pressure, and prevent scaling on a heat exchanger, and improve evaporation efficiency.