Abstract: The present invention relates to the field of bio-pharmaceuticals and, in particular, to an anti-Siglec-15 antibody or an antigen binding fragment thereof, a nucleic acid sequence encoding the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof, an expression vector containing the nucleic acid sequence, a host cell containing the expression vector, a composition or a bispecific antibody comprising the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof, an immune conjugate comprising the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof linked to a therapeutic agent, as well as use of the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof in the preparation of a medicament for treatment of cancer.

Abstract: The present invention discloses a polylactic acid composite and use thereof. The polylactic acid composite includes the following components: (A) 89 to 98 parts by weight of polylactic acid; (B) 1 to 4 parts by weight of talcum powder; and (C) 1 to 7 parts by weight of a plasticizer. In the component (A), the polylactic acid has a polydispersity index P satisfying the following relationship: 1.55?P?2.02. In the component (B), the talcum powder has a particle size D(50) satisfying: 1 ?m?D(50)?2.6 ?m. In the component (C), the plasticizer has a relative molecular weight M satisfying: 180?M?670. Through research, the present invention has unexpectedly discovered that by using the polylactic acid having the polydispersity index P satisfying the relationship 1.55?P?2.

Abstract: The present invention discloses a polylactic acid composite and use thereof. The polylactic acid composite includes the following components: (A) 89 to 98 parts by weight of polylactic acid; (B) 1 to 4 parts by weight of talcum powder; and (C) 1 to 7 parts by weight of a plasticizer. In the component (A), the polylactic acid has a polydispersity index P satisfying the following relationship: 1.55?P?2.02. In the component (B), the talcum powder has a particle size D(50) satisfying: 1 ?m?D(50)?2.6 ?m. In the component (C), the plasticizer has a relative molecular weight M satisfying: 180?M?670. Through research, the present invention has unexpectedly discovered that by using the polylactic acid having the polydispersity index P satisfying the relationship 1.55?P?2.