Patents by Inventor Shijia Yan

Shijia Yan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chromogenic substrates of sialidase of bacterial, viral, protozoa and vertebrate origin and methods of making and using the same
    Publication number: 20040180393
    Abstract: The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
    Type: Application
    Filed: October 6, 2003
    Publication date: September 16, 2004
    Inventors: Stephen C. Johnson, Ming Luo, Shijia Yan
  • Chromogenic substrates of sialidase of bacterial, viral, protozoa, and vertebrate origin and methods of making and using the same
    Patent number: 6667161
    Abstract: The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
    Type: Grant
    Filed: October 5, 1999
    Date of Patent: December 23, 2003
    Assignees: Ibbex, Inc., UAB Research Foundation
    Inventors: Stephen C. Johnson, Ming Lou, Shijia Yan
  • Methods of synthesizing sultams and anti-viral compositions
    Patent number: 6562850
    Abstract: The invention relates to a new class of compounds herein identified generally as “sultams”, which may be represented by the following formula V, in FIG. 1, in which numbering of the atoms is started with the sulfur atom of the isothiazole. Two of the rings (rings A and C) are aromatic, and the third is a heterocyclic ring (ring B), a cyclic sulfonamide. Of particular importance are the enantiomerically pure sultams since they are especially potent HIV-1 inhibitors.
    Type: Grant
    Filed: July 15, 1999
    Date of Patent: May 13, 2003
    Assignee: The University of Tennessee Research Corporation
    Inventors: David C. Baker, Anand Mayasundari, Jianmin Mao, Stephen C. Johnson, Shijia Yan
  • Synthesis of optically active calanolides A and B and enantiomers and related compounds
    Patent number: 5608085
    Abstract: A method of synthesis of the four optically active stereoisomers of calanolide A and B which produces the compounds in high yields and in a high degree of purity.
    Type: Grant
    Filed: February 27, 1995
    Date of Patent: March 4, 1997
    Assignee: The University of Tennessee Research Corporation
    Inventors: David C. Baker, Prashant P. Deshtande, Shijia Yan, Frank Tagliaferri, Samuel F. Victory