Patents by Inventor Shiladitya DasSarma

Shiladitya DasSarma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230270686
    Abstract: The present disclosure relates to a recombinant gas vesicle nanoparticle, and the recombinant gas vesicle nanoparticle prepared by the method of the present disclosure is a nano-sized protein particle that it is biologically non-toxic and safe. Further, its outer surface protein, GvpC, can be recombined to include the exogenous protein to reconstitute gas vesicle nanoparticles presenting/mounting the exogenous protein on the surface, so that it can be used as various antigen-loaded vaccine compositions that are active under physiological conditions, therapeutic target-specific carriers, including a sensor for target-specific therapy.
    Type: Application
    Filed: November 14, 2022
    Publication date: August 31, 2023
    Applicant: PUKYONG NATIONAL UNIVERSITY INDUSTRY UNIVERSITY COOPERATION FOUNDATION
    Inventors: Jong-Myoung KIM, Shiladitya DASSARMA, Priya DASSARMA
  • Publication number: 20100285559
    Abstract: The present invention relates to variants of the model halophile Halobacterium sp. NRC-1 that have been exposed to cycles of irradiation with high doses of 18-20 MeV electrons. These novel isolated halobacterium exhibit increased resistance to radiation and may be used for bioremediation of toxic and highly radioactive waste sites and/or for studying and modulating the mechanism involved in such resistance.
    Type: Application
    Filed: September 25, 2008
    Publication date: November 11, 2010
    Inventors: Shiladitya DasSarma, Linda Deveaux, Douglas P. Wells
  • Patent number: 6008051
    Abstract: The present invention is directed to a recombinant vector capable of directing the synthesis of gas vesicles in a non-floating cells. Cells transformed by the vector of the invention are also provided. The present invention is further directed to a method for conferring buoyancy to non-floating cells. The method of the instant invention is useful in harvesting cells, for example in fermentation processes, and in bioremediation, for example in conferring buoyancy to hydrocarbon-degrading bacteria.
    Type: Grant
    Filed: July 16, 1996
    Date of Patent: December 28, 1999
    Assignee: University of Massachusetts
    Inventors: Shiladitya DasSarma, John Halladay, Wai-lap Ng
  • Patent number: 5824309
    Abstract: The invention features a composition that includes a substantially pure recombinant gas vesicles which have at least one heterologous peptide inserted into at one of their structural proteins. The recombinant gas vesicle, when administered to a mammal, is capable of eliciting antibodies which specifically bind to the heterologous peptide. The heterologous peptide can be any peptide against which one wishes to raise antibodies, e.g., a peptide found in the gp12O protein of human immunodeficiency virus (HIV).
    Type: Grant
    Filed: December 5, 1996
    Date of Patent: October 20, 1998
    Assignee: University of Massachusetts
    Inventors: Shiladitya DasSarma, Fazeela Morshed, Elizabeth Stuart, Samuel Black
  • Patent number: 5098838
    Abstract: The invention relates to a mutant glutamine synthetase (GS) enzyme which is resistant to inhibition by herbicidal GS inhibitors, such as phosphinothricin (PPT), genetic sequences coding therefor, plants cells and prokaryotes transformed with the genetic sequences, and herbicidal GS inhibitor-resistant plant cells and plants.
    Type: Grant
    Filed: July 24, 1990
    Date of Patent: March 24, 1992
    Assignee: The General Hospital Corporation
    Inventors: Howard Goodman, Shiladitya DasSarma, Edmund Tischer, Theresa K. Peterman
  • Patent number: 4975374
    Abstract: The invention relates to a mutant glutamine synthetase (GS) enzyme which is resistant to inhibition by herbicidal GS inhibitors, such as phosphinothricin (PPT), genetic sequences coding therefor, plants cells and prokaryotes transformed with the genetic sequences, and herbicidal GS inhibitor-resistant plant cells and plants.
    Type: Grant
    Filed: February 4, 1987
    Date of Patent: December 4, 1990
    Assignee: The General Hospital Corporation
    Inventors: Howard Goodman, Shiladitya DasSarma, Edmund Tischer, Theresa K. Peterman