Abstract: Provided is a computer-implemented method, including inputting to a trained machine learning classifier genomic information of a non-training subject that includes features from a tumor sample, wherein the trained machine learning classifier trained on features of tumor samples obtained from training subjects and their a responsiveness to checkpoint inhibition treatment and the machine-learning classifier is trained to predict responsiveness to the treatment, and generating a checkpoint inhibition responsiveness classification predictive of the subject's responding to the checkpoint inhibition with the trained machine-learning classifier, and reporting the checkpoint inhibition responsiveness classification using a graphical user interface. Also provided are a computer system for performing the method and a machine learning classifier trained by the method.

Abstract: A composition comprising a first, synthetic gel and a second gel is useful for the preparation of waterborne multicolor paints.

Abstract: Presented herein are techniques for determining microsatellite instability. The techniques include generating a reference sample dataset representative of or mimicing a hypothetical matched sample for an individual sample of interest. The reference sample dataset may be generated from a set of reference normal samples that are not matched to the sample of interest. For samples of interest lacking a matched sample, the reference sample dataset may be used to determine microsatellite instability and to provide an indication of a presence, absence, or degree of microsatellite instability of the sample of interest. The reference sample dataset may be generated such that individual microsatelliate regions associated with a high degree of variability between ethnic groups are filtered out, masked, or otherwise not considered.

Abstract: Presented herein are techniques for determining microsatellite instability. The techniques include generating a reference sample dataset representative of or mimicking a hypothetical matched sample for an individual sample of interest. The reference sample dataset may be generated from a set of reference normal samples that are not matched to the sample of interest. For samples of interest lacking a matched sample, the reference sample dataset may be used to determine microsatellite instability and to provide an indication of a presence, absence, or degree of microsatellite instability of the sample of interest. The reference sample dataset may be generated such that individual microsatelliate regions associated with a high degree of variability between ethnic groups are filtered out, masked, or otherwise not considered.

Abstract: Described is a multi-regional, multi-omics approach to uncovering the mechanisms of immune escape in carcinoma. Immunotherapy with ant-PD1 and anti-CTLA4 elicits a heterogeneous immunological response across different regions of the tumor. Several genetic alterations associated with high intra-tumoral heterogeneity (ITH) shape tumor microenvironment (TME).

Abstract: Provided herein are systems and methods for quantitating the HLA diversity in a solid tissue or circulating tumor DNA sample that is predictive of a patient's responsiveness to immune checkpoint inhibitory therapies.

Abstract: Disclosed is a composition and method of use of a stable biocide combination of glutaraldehyde and tris(hydroxymethyl) nitromethane by the addition of certain buffers and solvents.

Abstract: Disclosed is an optical detection system for detecting a decomposition product of a high-voltage device, including: a measurement gas chamber and a measurement host. The measurement gas chamber is disposed on the high-voltage device and is in communication with a gas chamber of the high-voltage device, a collimator and a reflector are disposed on two sides of the measurement gas chamber respectively, and the measurement host is connected to the collimator. The collimator is used for emitting measurement laser to the measurement gas chamber according to a laser signal sent by the measurement host, and receiving reflected laser from the reflector and transmitting the reflected laser to the measurement host. In the present invention, data collection and backhaul between a measurement host and a measurement gas chamber are implemented through a laser signal, thus avoiding electromagnetic interference and improving the safety of measurement for a high-voltage device.

Abstract: Provided is a computer-implemented method, including inputting to a trained machine learning classifier genomic information of a non-training subject that includes features from a tumor sample, wherein the trained machine learning classifier trained on features of tumor samples obtained from training subjects and their a responsiveness to checkpoint inhibition treatment and the machine-learning classifier is trained to predict responsiveness to the treatment, and generating a checkpoint inhibition responsiveness classification predictive of the subject's responding to the checkpoint inhibition with the trained machine-learning classifier, and reporting the checkpoint inhibition responsiveness classification using a graphical user interface. Also provided are a computer system for performing the method and a machine learning classifier trained by the method.

Abstract: A method of making a formulation may include a step of forming a mixture comprising: a hydrotrope, a surfactant, a water-immiscible solvent, an isocyanate monomer, a salt, fosthiazate and water. Further, a step of adding an amine to the mixture to polymerizing the isocyanate monomer may be performed.

Abstract: Described herein are sun care compositions comprising at least one sunscreen active and hollow mesoporous silica nanospheres, and methods of making and using the sun care compositions. The presently described sun care compositions further comprise at least one of a cosmetically acceptable emollient, humectant, vitamin, moisturizer, conditioner, oil, silicone, suspending agent, surfactant, emulsifier, preservative, rheology modifier, pH adjustor, reducing agent, anti-oxidant, and/or foaming or de-foaming agent.

Abstract: Disclosed is an optical detection system for detecting a decomposition product of a high-voltage device, including: a measurement gas chamber and a measurement host. The measurement gas chamber is disposed on the high-voltage device and is in communication with a gas chamber of the high-voltage device, a collimator and a reflector are disposed on two sides of the measurement gas chamber respectively, and the measurement host is connected to the collimator. The collimator is used for emitting measurement laser to the measurement gas chamber according to a laser signal sent by the measurement host, and receiving reflected laser from the reflector and transmitting the reflected laser to the measurement host. In the present invention, data collection and backhaul between a measurement host and a measurement gas chamber are implemented through a laser signal, thus avoiding electromagnetic interference and improving the safety of measurement for a high-voltage device.

Abstract: An organic/oil mixture used in an emulsion to form micro-capsules of the present disclosure. The organic/oil mixture includes abamectin; a non-polar solvent having a polarity (P) value of a Hansen solubility parameter of 0 to 3; a polar solvent of Formula (I): where R1 is a C1 to C15 alkyl; R2 is either H or a C1 to C8 alkyl; R3 is a C1 to C15 alkylene; and R4 is a C1 to C15 alkyl, where a sum of carbons in the R1, R2, R4 alkyls and R3 alkylene is 8 to 30; and 2.5 to 20 wt. % of an isocyanate, where each wt. % is based on the total weight of the organic/oil mixture and the sum of the wt. % of the abamectin, the non-polar solvent, the polar solvent and the isocyanate totals 100 wt. %.

Abstract: A gas turbine engine according to an exemplary aspect of the present disclosure includes, among other things, a bearing compartment, a seal assembly configured to establish a seal of the bearing compartment. The seal assembly includes a seal plate. The gas turbine engine further includes a gutter configured to collect oil slung from the seal plate. The gutter extends only partially around the seal plate. A method is also disclosed.

Abstract: A composition comprising a colored synthetic gel useful for the preparation of waterborne multicolor paints.

Abstract: A gas turbine engine according to an exemplary aspect of the present disclosure includes, among other things, a bearing compartment, a seal assembly configured to establish a seal of the bearing compartment. The seal assembly includes a seal plate. The gas turbine engine further includes a gutter configured to collect oil slung from the seal plate. The gutter extends only partially around the seal plate. A method is also disclosed.

Abstract: A potential prognostic biomarker is based on a combination of a composite score generated by sequence analysis of global human endogenous retrovirus (hERV)/retro-transposon transactivation and a cell signature generated using deconvolution of immune cells within a tumor sample for predicting the efficacy of chemotherapeutic agents and immune checkpoint inhibitors. Correlation analysis of the composite score with cell signature within a tumor sample enables survival analysis in individuals receiving chemotherapeutic agents and immune checkpoint inhibitors.