Patents by Inventor SHILPA PALAN

SHILPA PALAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITION COMPRISING RECOMBINANT CLOSTRIDIUM NEUROTOXIN
    Publication number: 20230285521
    Abstract: The invention provides methods for producing soluble di-chain BoNT/A protein.
    Type: Application
    Filed: January 4, 2023
    Publication date: September 14, 2023
    Applicant: IPSEN BIOINNOVATION LIMITED
    Inventors: Shilpa PALAN, Sai Man LIU, Gavin Stephen HACKETT
  • Compositions and methods for treatment of pain
    Patent number: 11753633
    Abstract: Embodied herein are engineered fusion proteins that bind and target nociceptor neurons, compositions comprising these engineered fusion proteins, and methods for treatment of pain using these engineered fusion proteins or compositions containing the engineered fusion proteins. The engineered fusion proteins contain domains derived from protein toxins such as the anthrax toxin, clostridial botulinum family of toxins, disulphide-containing toxins, and AB component type toxins.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: September 12, 2023
    Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, IPSEN PHARMA S.A.S.
    Inventors: R. John Collier, Isaac Chiu, Bradley L. Pentelute, Keith Alan Foster, Shilpa Palan, Sai Man Liu
  • Composition comprising recombinant clostridium neurotoxin
    Patent number: 11642399
    Abstract: The invention provides methods for producing soluble di-chain BoNT/A protein.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: May 9, 2023
    Assignee: IPSEN BIOINNOVATION LIMITED
    Inventors: Shilpa Palan, Sai Man Liu, Gavin Stephen Hackett
  • Methods for purifying clostridial neurotoxin
    Patent number: 11066451
    Abstract: A method for purifying a clostridial neurotoxin comprising contacting a cation exchange resin with a composition comprising a clostridial neurotoxin, wherein the contacting step is performed at at least pH 7.3, wherein the step of contacting a cation exchange resin with a composition comprising said clostridial neurotoxin occurs prior to conversion of the clostridial neurotoxin from a single chain form into a dichain form. Also provided are uses of a buffer having a pH value that is ?1 pH unit or higher than the calculated pi of a clostridial neurotoxin, purification intermediates and clostridial neurotoxins obtainable by the invention, wherein the clostridial neurotoxin is in a single chain form.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: July 20, 2021
    Assignee: IPSEN BIOPHARM LIMITED
    Inventors: Gavin Stephen Hackett, Shilpa Palan, Dina Brady Anderson
  • MANUFACTURE OF RECOMBINANT CLOSTRIDIAL BOTULINUM NEUROTOXINS
    Publication number: 20190201505
    Abstract: The invention provides methods for producing soluble di-chain BoNT/A protein.
    Type: Application
    Filed: March 8, 2019
    Publication date: July 4, 2019
    Applicant: IPSEN BIOINNOVATION LIMITED
    Inventors: Shilpa PALAN, Sai Man Liu, Gavin Stephen HACKETT
  • Manufacture of di-chain recombinant neurotoxins using Lys-C and a hydrophobic surface
    Patent number: 10307468
    Abstract: Methods for producing di-chain BoNT/A from single chain BoNT/A using Lys-C followed by purification using a hydrophobic surface.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: June 4, 2019
    Assignee: IPSEN BIOINNOVATION LIMITED
    Inventors: Shilpa Palan, Sai Man Liu, Gavin Stephen Hackett
  • Methods for Purifying Clostridial Neurotoxin
    Publication number: 20190100564
    Abstract: A method for purifying a clostridial neurotoxin comprising contacting a cation exchange resin with a composition comprising a clostridial neurotoxin, wherein the contacting step is performed at at least pH 7.3, wherein the step of contacting a cation exchange resin with a composition comprising said clostridial neurotoxin occurs prior to conversion of the clostridial neurotoxin from a single chain form into a dichain form. Also provided are uses of a buffer having a pH value that is ?1 pH unit or higher than the calculated pi of a clostridial neurotoxin, purification intermediates and clostridial neurotoxins obtainable by the invention, wherein the clostridial neurotoxin is in a single chain form.
    Type: Application
    Filed: September 27, 2016
    Publication date: April 4, 2019
    Inventors: Gavin Stephen HACKETT, Shilpa PALAN, Dina Brady ANDERSON
  • COMPOSITIONS AND METHODS FOR TREATMENT OF PAIN
    Publication number: 20180244731
    Abstract: Embodied herein are engineered fusion proteins that bind and target nociceptor neurons, compositions comprising these engineered fusion proteins, and methods for treatment of pain using these engineered fusion proteins or compositions containing the engineered fusion proteins. The engineered fusion proteins contain domains derived from protein toxins such as the anthrax toxin, clostridial botulinum family of toxins, disulphide-containing toxins, and AB component type toxins.
    Type: Application
    Filed: August 26, 2016
    Publication date: August 30, 2018
    Inventors: R. John Collier, Isaac Chiu, Bradley L. Pentelute, Keith Alan Foster, Shilpa Palan, Sai Man Liu
  • MANUFACTURE OF RECOMBINANT CLOSTRIDIUM BOTULINUM NEUROTOXINS
    Publication number: 20180117128
    Abstract: The invention provides methods for producing soluble di-chain BoNT/A protein.
    Type: Application
    Filed: April 29, 2015
    Publication date: May 3, 2018
    Applicant: Ipsen Bioinnovation Limited
    Inventors: SHILPA PALAN, SAI MAN LIU, GAVIN Stephen HACKETT