Abstract: A touch display substrate, a method for manufacturing a touch display substrate and a display apparatus are provided. The touch display substrate includes: a base substrate; at least one touch electrode, which includes a plurality of touch signal lines extending in preset directions, and the plurality of touch signal lines form a mesh structure; display signal lines on the base substrate and electrically connected to display pixels for providing display signals there to; second signal lines electrically connected to a constant potential terminal, and between a layer of the touch signal lines and a layer of the display signal lines. Orthographic projections of the second signal lines on the base substrate at least partially overlap with those of at least some touch signal lines; and/or orthographic projections of the second signal lines on the base substrate at least partially overlap with those of at least some display signal lines.