Patents by Inventor Shimoga R. PRAKASH

Shimoga R. PRAKASH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitor of breast cancer resistance protein (BCRP)
    Patent number: 9695174
    Abstract: Disclosed are compounds that inhibit breast cancer resistance protein (BCRP), of which compound (I-1), ((3S,6S,12aS)-6-isobutyl-9-methoxy-3-methyl-2,3,6,7,12,12a-hexahydropyrazino[1?,2?:1,6]pyrido[3,4-b]indole-1,4-dione) or a pharmaceutically acceptable salt thereof, and the compound 12, ((3S,6S,12aS)-6-isobutyl-9-methoxy-3,10-dimethyl-2,3,6,7,12,12a-hexahydropyrazino[1?,2?:1,6]pyrido[3,4-b]indole-1,4-dione) or a pharmaceutically acceptable salt thereof. Also disclosed are methods of inhibiting BCRP or decreasing BCRP activity and methods of determining potential BCRP substrates.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: July 4, 2017
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Yuexian Li, Shimoga R. Prakash, Cindy Qi Xia, Mingxiang M. Liao
  • INHIBITOR OF BREAST CANCER RESISTANCE PROTEIN (BCRP)
    Publication number: 20160214984
    Abstract: Disclosed are compounds that inhibit breast cancer resistance protein (BCRP), of which compound (I-1), ((3S, 6S, 12aS)-6-isobutyl-9-methoxy-3-methyl-2,3,6,7, 12, 12a- hexahydropyrazino[1?,2?: 1,6]pyrido[3,4-b]indole-1,4-dione) or a pharmaceutically acceptable salt thereof, and the compound 12, ((3S,6S,12aS)-6-isobutyl-9-methoxy-3,10- dimethyl-2,3,6,7,12, 12a-hexahydropyrazino[1?,2?: 1,6]pyrido[3,4- b] indole-1,4-dione) or a pharmaceutically acceptable salt thereof. Also disclosed are methods of inhibiting BCRP or decreasing BCRP activity and methods of determining potential BCRP substrates.
    Type: Application
    Filed: October 6, 2014
    Publication date: July 28, 2016
    Inventors: Yuexian LI, Shimoga R. PRAKASH, Cindy Qi XIA, Mingxiang M. LIAO