Abstract: A method for producing hemostasis of an artery of a patient having a puncture following arterial catheterization including introducing a hemostasis device including at least one electrode into the vicinity of the puncture, supplying an electric current to the at least one electrode, thereby heating blood in the vicinity of the puncture and causing coagulation of the blood and subsequently removing the hemostasis device from the patient.

Abstract: Systems, apparatuses and methods are provided for use in closing punctures in vessel walls. An apparatus may have various combinations of an anchoring device, a positioning device and a heating element for closing a puncture within a vessel wall. An anchoring device may be a balloon, an expansible cage, a wire operated T-anchor, and/or a floating anchor. A positioning device may be a balloon, a sponge, and/or an expansible cage. A heating element may be flexible or rigid and preferably provides heat to target tissue through conduction and convection. A heating element may be flat-ended or dome-shaped. The heating element and anchoring device may be positioned a fixed distance apart to sandwich tissue between the heating element and the anchoring device. The heating element may operate in multiple stages. An initial stage may non-permanently adhere the heating element to the tissue and the subsequent stage may close the puncture.

Abstract: A stinging cell comprising an exogenous polynucleotide capable of expressing a therapeutic, cosmetic or diagnostic agent in the stinging cell is provided.

Abstract: We describe devices, methods, and systems used for hair removal. In particular, we describe hair removal devices, particularly epilation devices, methods of using those devices, and systems including those hair removal devices. Our hair removal devices include, in combination, a.) at least one primary energy source that applies that energy, e.g., radio-frequency (RF), high intensity focused ultrasonic (HIFU) energy, or high intensity light, e.g., intense-pulsed light (IPL) or light from flash lamps or lasers, to the skin or to hair in a continuous, semi-continuous, or pulsed mode and b.) a hair removal component or components, such as rotary mechanical hair removal structures or epilators, that perform a mechanical hair removal step. Auxiliary treatment or control components such as comparatively lower power heaters, ultrasound devices, coolers, impedance measurement devices, etc. may also be included in the combination or used in conjunction with our combination device.

Abstract: A composition of matter comprising an agent beneficial to a non-skin keratinous substance and at least one stinging capsule and methods of use are disclosed.

Abstract: A shaver that includes a cartridge with one or more razor blades and a source of RF energy operative to apply RF energy to one or more of the blades. The cartridge can be attached to a handle for moving the cartridge along the surface of the skin. The cartridge may include a variety of configurations including one or more electrodes and one or more blades with the RF current conducting through any subset of the electrodes and blades, through the skin, thereby heating the skin to help facilitate the engagement of the blade with the hair on the skin surface.

Abstract: Described herein are bioerodible, biodegradable, or digestible self-deploying intragastric implants that may be swallowed. Once swallowed, the implants undergo self-expansion in the stomach and apply a suitable pressure against the stomach wall to provide a feeling of satiety to the individual. The implants then dissolve or are disassembled perhaps using gastric liquids and pass out of the stomach. Methods of using the devices, perhaps for an individual participating in a dietary control regimen, are described.

Abstract: Disclosed is an article designed to attenuate intensive and unwanted light emitted by an IPL or laser device that may occasionally reach the eyes of a user or operator, while not limiting their ability to see in a bright region. Eye protection is achieved by an assembly of baffles extending towards the source of IPL. The baffles limit the field of view of the article to a value sufficient for coupling a safe amount of light intensity enabling comfortable IPL or laser applicator tracking and operation.

Abstract: We describe devices, methods, and systems used for hair removal. In particular, we describe hair removal devices, particularly epilation devices, methods of using those devices, and systems including those hair removal devices. Our hair removal devices include, in combination, a.) at least one primary energy source that applies that energy, e.g., radio-frequency (RF), high intensity focused ultrasonic (HIFU) energy, or high intensity light, e.g., intense-pulsed light (IPL) or light from flash lamps or lasers, to the skin or to hair in a continuous, semi-continuous, or pulsed mode and b.) a hair removal component or components, such as rotary mechanical hair removal structures or epilators, that perform a mechanical hair removal step. Auxiliary treatment or control components such as comparatively lower power heaters, ultrasound devices, coolers, impedance measurement devices, etc. may also be included in the combination or used in conjunction with our combination device.

Abstract: A clot removal device and method for removing a clot from a blood vessel may employ a tubular clot capture element. The clot capture element may be configured for deployment in a blood vessel for surrounding a clot. The clot capture element may have an opening therein configured to receive and guide a clot engaging element and may be configured to radially contract upon retraction, such that when the clot capture element surrounds a clot and is retracted in a longitudinal direction of the blood vessel, the clot capture element is configured to exert a radially inward compression force on the clot.

Abstract: A clot removal device and method may employ a shaft and a clot engagement element on an end of the shaft. The clot engagement element and the shaft may be configured for deployment in a blood vessel. The clot removal device may also include a stabilizer configured to at least partially surround the shaft and to maintain a portion of the shaft in a non-contacting relationship with the blood vessel wall.

Abstract: The invention provides methods and apparatuses for the treatment of adipose tissue. The methods comprise application of ultrasound energy to a region of adipose tissue, and the apparatuses comprise at least one source of ultrasound energy configured to direct ultrasound energy through a skin surface into the subcutaneous adipose tissue. In one embodiment, a pressure gradient is created in the region generating relative movement between fat cell constituents having different densities. In another embodiment, a protrusion of skin and underlying adipose tissue containing is formed and ultrasound energy is radiated into the adipose tissue in the protrusion. In another embodiment, an RF electric field is generated inside a region of adipose tissue together with the ultrasound energy.

Abstract: The invention provides methods and apparatuses for the treatment of adipose tissue. The methods comprise application of ultrasound energy to a region of adipose tissue, and the apparatuses comprise at least one source of ultrasound energy configured to direct ultrasound energy through a skin surface into the subcutaneous adipose tissue. In one embodiment, a pressure gradient is created in the region generating relative movement between fat cell constituents having different densities. In another embodiment, a protrusion of skin and underlying adipose tissue containing is formed and ultrasound energy is radiated into the adipose tissue in the protrusion. In another embodiment, an RF electric field is generated inside a region of adipose tissue together with the ultrasound energy.

Abstract: A method for producing hemostasis of an artery of a patient having a puncture following arterial catheterization including introducing a hemostasis device including at least one electrode into the vicinity of the puncture, supplying an electric current to the at least one electrode, thereby heating blood in the vicinity of the puncture and causing coagulation of the blood and subsequently removing the hemostasis device from the patient.

Abstract: The invention provides methods and apparatuses for the treatment of adipose tissue. The methods comprise application of ultrasound energy to a region of adipose tissue, and the apparatuses comprise at least one source of ultrasound energy configured to direct ultrasound energy through a skin surface into the subcutaneous adipose tissue. In one embodiment, a pressure gradient is created in the region generating relative movement between fat cell constituents having different densities. In another embodiment, a protrusion of skin and underlying adipose tissue containing is formed and ultrasound energy is radiated into the adipose tissue in the protrusion. In another embodiment, an RF electric field is generated inside a region of adipose tissue together with the ultrasound energy.

Abstract: A clot removal device and method for removing a clot from a blood vessel may include an expandable clot engagement element, an expandable clot capture element, and a sheath surrounding and compressing the capture element and the engagement element. The sheath may be removable to thereby enable the capture element to expand in a blood vessel in which the sheath is deployed, and to enable the engagement element to expand within the capture element.

Abstract: A clot removal device may include a tubular clot capture element having a first internal diameter and a clot engaging element having a second external diameter. The first diameter and the second diameter may be selected to permit the clot engaging element to be rotated within the tubular clot capture element. A method of removing a clot from a blood vessel may including delivering the tubular clot capture element and clot engaging element to a clot site such that the clot engaging element may rotate within the tubular clot engaging element.

Abstract: A delivery device including at least one stinging capsule and methods of use are described.

Abstract: A composition of matter comprising an agent beneficial to a non-skin keratinous substance and at least one stinging capsule and methods of use are disclosed.

Abstract: A technique for detecting and providing alerts or indications that can be used for controlling or altering the displacement speed of an applicator coupling skin heating energy across a treated skin. A temperature sensor monitors the rate of skin temperature change and provides feedback related to altering the applicator displacement speed according to the rate of skin temperature change. Disclosed is also an applicator for implementing this method.