Patents by Inventor Shimshi ATAR

Shimshi ATAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Attenuated virus mutated at sites of evolutionarily conserved RNA structure
    Patent number: 11795440
    Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
    Type: Grant
    Filed: September 5, 2021
    Date of Patent: October 24, 2023
    Assignees: RAMOT AT TEL-AVIV UNIVERSITY LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD., SYNVACCINE LTD.
    Inventors: Tamir Tuller, Eli Goz, Shimshi Atar, Hadas Zur
  • ATTENUATED VIRUS MUTATED AT SITES OF EVOLUTIONARILY CONSERVED RNA STRUCTURE
    Publication number: 20220010287
    Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
    Type: Application
    Filed: September 5, 2021
    Publication date: January 13, 2022
    Applicants: RAMOT AT TEL-AVIV UNIVERSITY LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD., SYNVACCINE LTD.
    Inventors: Tamir TULLER, Eli GOZ, Shimshi ATAR, Hadas ZUR
  • Attenuated virus mutated at sites of evolutionarily conserved RNA structure
    Patent number: 11111481
    Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: September 7, 2021
    Assignees: RAMOT AT TEL-AVIV UNIVERSITY LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD., SYNVACCINE LTD.
    Inventors: Tamir Tuller, Eli Goz, Shimshi Atar, Hadas Zur
  • ATTENUATED VIRUS MUTATED AT SITES OF EVOLUTIONARILY CONSERVED RNA STRUCTURE
    Publication number: 20180273911
    Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
    Type: Application
    Filed: September 29, 2016
    Publication date: September 27, 2018
    Inventors: Tamir TULLER, Eli GOZ, Shimshi ATAR, Hadas ZUR