Abstract: A sensing unit is disclosed. The sensing unit includes: a first compartment which includes a first group of polymer beads carrying genetically engineered cells configured to produce a reporter when exposed to a target material; and a first detector configured to detect the reporter; and a second compartment having: a second group of the polymer beads carrying the genetically engineered cells configured to produce the reporter when exposed to the target material; and a second detector configured to detect the reporter. The second compartment is impenetrable to the target material and the first compartment is penetrable to the target material.

Abstract: A system for analyzing a liquid is provided. The system comprises: an electrochemical unit having an electrochemical microchamber for receiving a sample of the liquid and electrochemically analyzing the sample; and a microfluidic unit being attached to the electrochemical unit and having microchannels constituted for sampling the sample in situ and feeding the sample to the electrochemical microchamber. Also provided are nucleic acid constructs and cells comprising same for analyte detection.

Abstract: A system and method are presented for monitoring detectable responses from multiple biosensing elements while in contact with multiple samples located in an array. The system (1000) comprises an exciting unit (100), and a detection unit (120). The exciting unit (100) is configured for producing an array of exciting signals (102) each characterized by a frequency differing from those of the other exciting signals, and exciting a corresponding array of the biosensing elements (110), thereby enabling each biosensing element to generate a response signal (130) tagged by the different frequency. The detection unit (120) comprises a single receiving element associated with said array of biosensing elements (110) and configured for concurrently receiving the multiple response signals and generating a single output signal (140) indicative thereof. The system thereby enables to identify signal parts corresponding to the response signals of the spatially separated biosensing elements.

Abstract: A system for analyzing a liquid is provided. The system comprises: an electrochemical unit having an electrochemical microchamber for receiving a sample of the liquid and electrochemically analyzing the sample; and a microfluidic unit being attached to the electrochemical unit and having microchannels constituted for sampling the sample in situ and feeding the sample to the electrochemical microchamber. Also provided are nucleic acid constructs and cells comprising same for analyte detection.

Abstract: A system and method are presented for monitoring detectable responses from multiple biosensing elements while in contact with multiple samples located in an array. The system (1000) comprises an exciting unit (100), and a detection unit (120). The exciting unit (100) is configured for producing an array of exciting signals (102) each characterized by a frequency differing from those of the other exciting signals, and exciting a corresponding array of the biosensing elements (110), thereby enabling each biosensing element to generate a response signal (130) tagged by the different frequency. The detection unit (120) comprises a single receiving element associated with said array of biosensing elements (110) and configured for concurrently receiving the multiple response signals and generating a single output signal (140) indicative thereof. The system thereby enables to identify signal parts corresponding to the response signals of the spatially separated biosensing elements.

Abstract: A portable system for detecting agents present in a sample is disclosed. The system comprises a sensing device, having a substrate formed with a plurality of reaction chambers and a plurality of channels interconnecting at least a portion of the plurality of reaction chambers, wherein at least a portion of the plurality of reaction chambers comprises a sensor, capable of generating a detectable signal when exposed to the agents. The system further comprises a detector, which receives signals from the sensing device and provides an image of sensors generating the optical signals. The portable system is connected to a communication network via a communication unit.

Abstract: A method of detecting the presence of harmful agents in the environment is disclosed. The method comprises: providing a plurality of portable agent detectors, placing the detectors on vectors in the environment, connecting the detectors over a communication network, and, upon detection of an agent by a first detector, signaling detectors identified as being nearby to carry out corresponding agent detection tests, thereby to confirm or localize an initial agent detection.

Abstract: A population of cells is provided. The population of cells comprising at least two subpopulations of cells, wherein a first subpopulation of the at least two subpopulation of cells includes a first reporter expression construct being expressible in a cell of the first subpopulation when exposed to a first analyte and whereas a second subpopulation of the at least two subpopulation of cells includes a second reporter expression construct being expressible in a cell of the second subpopulation when exposed to a second analyte.

Abstract: A device for detecting a presence of an analyte in a sample. The device comprises a device body configured with at least one reaction chamber configured for containing a sensor capable of producing a detectable signal when exposed to the analyte in the sample. The reaction chambers are in fluid communication with at least one sample port and at least one actuator port via a first set of microfluidic channels arranged such that application of a negative pressure to actuator port delivers fluid placed in the sample port to the reaction chambers.