Abstract: Provided is a mold structure with a fast replacement of a mold core, including an upper mold base and a lower mold base corresponding to the upper mold base. The upper mold base is provided with at least one upper mold base, wherein the bottom of the upper mold base is provided with a push-pull device, the push-pull device includes a pressure cylinder and a push-pull rod capable of expansion and contraction and the upper mold core is driven by the expansion and contraction of the push-pull rod, and is relatively separated from or embedded in the upper mold base, and wherein the bottom of the upper mold core is provided with a chute, and the upper mold core is operatively coupled with or separated from the push-pull rod by the chute. Consequently, the action of replacing the mold core is performed.