Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.

Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.

Abstract: The present invention provides an inflammatory pulmonary disease agent capable of effectively preventing and/or treating an inflammatory pulmonary disease, and specifically relates to a prophylactic and/or therapeutic agent for an inflammatory pulmonary disease containing, as an active ingredient, an antibody or an antibody fragment having antigen-binding activity for an S100A8/A9 heterodimer. The inflammatory pulmonary disease can be effectively prevented and/or treated by blocking interaction between S100A8/A9 and a group of receptors therefor. Specifically, the inflammatory pulmonary disease can be effectively prevented and/or treated by: blocking interaction between S100A8/A9 and RAGE, which is a receptor therefor, to suppress: the expression of NF-?B, which is a transcription factor present downstream of RAGE and induces the expression of various inflammatory cytokines; the proliferation of activated fibroblasts; and the differentiation of activated fibroblasts into myofibroblasts.

Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.

Abstract: The present invention provides a method of determining a lung cancer treatment, the method comprising: measuring an amount of KL-6 in a sample of body fluid from a subject, and determining the treatment based on the amount of KL-6 measured, and a method of determining the effectiveness of an agent for treatment of lung cancer on a subject, the method comprising: measuring an amount of KL-6 in a sample of body fluid from the subject, determining the effectiveness of an EGFR inhibitor on the subject should the EGFR inhibitor be administered as the agent for treatment of lung cancer, based on the amount of KL-6 measured.

Abstract: The present invention is directed to a cooking container for use in heating food in a microwave oven. Specifically, the present invention concerns a cooking utensil capable of heating itself up by microwaves to heat food to such an extent as to be browned but not to be scorched and be stuck to the cooking surface. A fluororesin layer 1 is formed on the top surface of a metal plate 2, and a heat buildup layer 3 adapted to be dielectrically heated by microwaves is formed on the bottom thereof. A covering 4 permeable to microwaves is provided on the outside of the heat buildup layer. The covering is partially formed into legs to support the bottom surface of the plate. A lid capable of reflecting microwaves may be put on the metal plate to shield the food to be cooked against microwaves.

Abstract: The invention provides an elastic roller for use in an apparatus for fixing a toner image, electrostatically formed on copy paper by passing the toner image between two rollers, comprising a roller core, a fusible fluororesin layer coated on the outside of the roller core, a porous fluororesin having porous portions affixed to the roller core through the fusible fluororesin layer, and a rubber impregnated into the porous portions of the porous fluororesin. It also provides a method for making an elastic roller including the steps of fusing a fusible fluororesin layer on the outside of a roller core or base; affixing a porous fluororesin having porous portions to the roller core through the fused fluororesin layer; filling the porous portions of the porous fluororesin with a rubber after fusing the porous fluororesin to the roller core; and hardening the rubber.

Abstract: A liquid membrane is disclosed, which comprises a solvent, an active species capable of facilitated transport of a specific gas, and a support for maintaining a liquid body which has a mixture of said solvent and active species dissolved therein, said support being a porous polytetrafluoroethylene film one surface of which is hydrophobic and the other of which is hydrophilic.

Abstract: A liquid membrane is disclosed, which comprises a solvent, an active species capable of performing facilitated transport of a specific gas, and a support for maintaining a liquid mixture of the solvent and the active species, wherein the active species has the structure represented by the following formula: ##STR1##

Abstract: Apparatus for manufacturing a porous polytetrafluoroethylene material comprising extruding or rolling or a process consisting of the both an unsintered polytetrafluoroethylene mixture containing a liquid lubricant, and carrying out simultaneously next four steps of (a) evaporating a liquid lubricant, (b) stretching the molded articles in an unsintered condition, (c) sintering the same in a stretched condition, and (d) stretching the same in a sintered condition at an atmospheric temperature of more than 390.degree. C. to obtain mechanical strengths such as a Young's modulus of more than 10000 kg/cm.sup.2, and a matrix tensile strength of more than 1100 kg/cm.sup.2.

Abstract: A highly weather-proof high strength membrane material which comprisesa polyvinyl fluoride resin film coated with an adhesive layer on one side thereof,a urethane resin applied by spraying on the adhesive layer,a triaxially woven fabric of polyaramide fibers as reinforcing fibers adhered on one surface thereof onto the sprayed urethane layer, anda urethane resin applied by spraying on another surface of the fabric. This membrane causes creases to occur with difficulty and does not deteriorate radio wave permeability.