Abstract: A method for diagnosing the probability of the onset of glaucoma or the degree of the advancement of glaucoma by observing connective tissue of lamina cribrosa and its neighboring part of retina, namely the movable nature of lamina cribrosa in relation to retina.

Abstract: A method for diagnosing the probability of the onset of glaucoma or the degree of the advancement of glaucoma by observing connective tissue of lamina cribrosa and its neighboring part of retina, namely the movable nature of lamina cribrosa in relation to retina.

Abstract: Provided is an observation device and a method of observing capable of clearly obtaining information relating to a boundary part where a medium inside an observation object changes. An observation device (1) is a device for observing an observation object (2) including a sensitivity factor in which a dipole moment changes by sensing an electromagnetic wave (31). An output part (11) outputs the electromagnetic wave (31) and the dipole moment of the sensitivity factor included in the observation object (2) is changed by the electromagnetic wave (31). A detector part (12) detects, of the electromagnetic wave (31) outputted from the output part (11), a signal electromagnetic wave (33) which comes through the observation object (2) and a reference electromagnetic wave (32) which bypasses the observation object (2). A control part (13) analyzes the structure of the observation object (2) based on the detection results of the detection part (12).

Abstract: A reflection surface 12 constituted by a transition metal having a core level absorption edge in the vicinity of a wavelength of a soft X-ray is formed on an inside of a vacuum vessel 14, and furthermore, there is provided a permanent magnet 13 for generating a magnetic field in a perpendicular direction to a longitudinal direction of the vacuum vessel 14 in a position of the reflection surface 12 by which the soft X-ray is to be reflected, and the soft X-ray to be linearly polarized light incident on the vacuum vessel 14 is reflected at plural times over the reflection surface 12 in a position where the magnetic field is applied in such a manner that magnetic scattering is increased by a resonant effect of a magnetic circular dichroism when the soft X-ray is reflected by the reflection surface 12.

Abstract: Provided is an observation device and a method of observing capable of clearly obtaining information relating to a boundary part where a medium inside an observation object changes. An observation device (1) is a device for observing an observation object (2) including a sensitivity factor in which a dipole moment changes by sensing an electromagnetic wave (31). An output part (11) outputs the electromagnetic wave (31) and the dipole moment of the sensitivity factor included in the observation object (2) is changed by the electromagnetic wave (31). A detector part (12) detects, of the electromagnetic wave (31) outputted from the output part (11), a signal electromagnetic wave (33) which comes through the observation object (2) and a reference electromagnetic wave (32) which bypasses the observation object (2). A control part (13) analyzes the structure of the observation object (2) based on the detection results of the detection part (12).

Abstract: A reflection surface 12 constituted by a transition metal having a core level absorption edge in the vicinity of a wavelength of a soft X-ray is formed on an inside of a vacuum vessel 14, and furthermore, there is provided a permanent magnet 13 for generating a magnetic field in a perpendicular direction to a longitudinal direction of the vacuum vessel 14 in a position of the reflection surface 12 by which the soft X-ray is to be reflected, and the soft X-ray to be linearly polarized light incident on the vacuum vessel 14 is reflected at plural times over the reflection surface 12 in a position where the magnetic field is applied in such a manner that magnetic scattering is increased by a resonant effect of a magnetic circular dichroism when the soft X-ray is reflected by the reflection surface 12.

Abstract: In one aspect, the invention features a method and device for measuring blood concentration of a substance such as glucose in the aqueous humor by illuminating the aqueous humor with a light source at a frequency that is absorbed by the substance to the measured, and then sensing photoacoustically generated sound waves originated within the aqueous humor as a consequence of illumination by the light source. The blood concentration can be estimated from the amplitude of the sound waves received. The method may be combined with other optical techniques for glucose measurement and/or with optical or ultrasonic techniques for topographic mapping of eye structures.

Abstract: The present invention relates to a method, including the steps of mapping at least a portion of the fundus of the eye by forming a plurality of pixels, estimating the oxygen saturation level at each of the plurality of pixels, superimposing the fundus maps on maps of anatomic borderlines, and comparing portions of the superimposed fundus maps to predetermined fundus maps.

Abstract: The present invention relates to a method, including the steps of mapping at least a portion of the fundus of the eye by forming a plurality of pixels, estimating the oxygen saturation level at each of the plurality of pixels, superimposing the fundus maps on maps of anatomic borderlines, and comparing portions of the superimposed fundus maps to predetermined fundus maps.

Abstract: In one aspect, the invention features a method and device for measuring blood concentration of a substance such as glucose in the aqueous humor by illuminating the aqueous humor with a light source at a frequency that is absorbed by the substance to the measured, and then sensing photoacoustically generated sound waves originated within the aqueous humor as a consequence of illumination by the light source. The blood concentration can be estimated from the amplitude of the sound waves received. The method may be combined with other optical techniques for glucose measurement and/or with optical or ultrasonic techniques for topographic mapping of eye structures.

Abstract: In one aspect, the invention features a method and device for measuring blood concentration of a substance such as glucose in the aqueous humor by illuminating the aqueous humor with a light source at a frequency that is absorbed by the substance to the measured, and then sensing photoacoustically generated sound waves originated within the aqueous humor as a consequence of illumination by the light source. The blood concentration can be estimated from the amplitude of the sound waves received. The method may be combined with other optical techniques for glucose measurement and/or with optical or ultrasonic techniques for topographic mapping of eye structures.

Abstract: A method is provided for selectively occluding neovascular vessels formed in the ocular fundus of an eye, which includes intravenously administering a mono-L-aspartyl chlorin compound to a patient; subsequently estimating an appropriate time point when the mono-L-aspartyl chlorin compound has decreased in its concentration or has been eliminated from the retinal normal vascular vessels of the patient but is still remaining at an appropriate concentration in the vascular walls of the neovascular vessels of the ocular fundus; irradiating a laser light at a 664 nm-wavelength which is initiated at the appropriate time; and using the irradiation of the laser light to target lesions comprising the neovascular vessels, at a controlled power.

Abstract: A fundus photographing device for conducting infrared fluorescence photography on a fundus of an examinee's eye after intravenously injecting a fluorescent agent which emits fluorescence of an infrared region into veins is disclosed. This device includes an illumination optical system 1 for illuminating the fundus with exciting light, thereby exciting the injected fluorescent agent, the exciting light being of wavelengths in a wavelength region of not maximum absorption but maximum fluorescent intensity of the fluorescent agent.

Abstract: A fundus photographing device for conducting infrared fluorescence photography on a fundus of an examines's eye after intravenously injecting a fluorescent agent which emits fluorescence of an infrared region into veins is disclosed. This device includes an illumination optical system 1 for illuminating the fundus with exciting light, thereby exciting the injected fluorescent agent, the exciting light being of wavelengths in a wavelength region of not maximum absorption but maximum fluorescent intensity of the fluorescent agent.

Abstract: An apparatus for clogging blood vessels of an eye fundus includes an illuminating optical system (1) for illuminating an eye fundus of a subject, who has been given an injection of an infrared fluorescent agent, with infrared rays of light and exciting the infrared fluorescent agent so as to generate infrared fluorescence, a photographic optical system (2) for observing and photographing the eye fundus, and a projecting optical system (21) for projecting a laser beam of light having a specific wavelength onto the subject who has been also given an injection of a photosensitive substance which undergoes a photochemical change by the laser beam. In the apparatus, while a region which emits infrared fluorescence is being observed, the laser beam is projected onto the photosensitive substance so as to clog blood vessels of a diseased part in the depth of the eye fundus.

Abstract: A photosensitive tetrapyrrole derivative having formula (I) ##STR1## where n stands for 1 or 2 or a pharmaceutically acceptable salt thereof is useful as an effective ingredient in an obstruent composition for photochemotherapeutically obstructing neovascular vessels. The photosensitive tetrapyrroles of the formula (I) may be administered in a photochemotherapeutic method for obstructing neovascular vessels, particularly choroidal and retinal neovascularizations.

Abstract: The present invention relates to a fundus camera for photographing vascular condition of the retina in medical examination for checking health, and it comprises a retina illuminating system for projecting infrared illuminating light beam to the retina to be examined, a first barrier filter having a first transmission wavelength range and a second barrier filter having a second transmission wavelength range shifted toward longer wavelength range, said two barrier filters being interchangeable with each other, and a photographing system for angiography of the retina to be examined through either the first or the second barrier filters, whereby a proper fluorescent vascular image is photographed even when fluorescent light wavelength from the retina is changed with the lapse of time.

Abstract: A photosensitive tetrapyrrole derivative having formula (I) where n stands for 1 or 2 or a pharmaceutically acceptable salt thereof is useful as an effective ingredient in an obstruent composition for photochemotherapeutically obstructing neovascular vessels. The photosensitive tetrapyrroles of the formula (I) may be administered in a photochemotherapeutic method for obstructing neovascular vessels, particularly choroidal and retinal neovascularizations.

Abstract: An apparatus for clogging blood vessels of an eye fundus includes an illuminating optical system (1) for illuminating an eye fundus of a subject, who has been given an injection of an infrared fluorescent agent, with infrared rays of light and exciting the infrared fluorescent agent so as to generate infrared fluorescence, a photographic optical system (2) for observing and photographing the eye fundus, and a projecting optical system (21) for projecting a laser beam of light having a specific wavelength onto the subject who has been also given an injection of a photosensitive substance which undergoes a photochemical change by the laser beam. In the apparatus, while a region which emits infrared fluorescence is being observed, the laser beam is projected onto the photosensitive substance so as to clog blood vessels of a diseased part in the depth of the eye fundus.