Patents by Inventor Shingo Hatakeyama
Shingo Hatakeyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210138274Abstract: The purpose of the present invention is to provide a 10B medicine that can be selectively accumulated in tumor tissues at a low dose in a short time, and can be applied to BNCT. The 10B medicine comprises a compound containing: a peptide capable of selectively binding to tumor vascular endothelial cells; and 10B, wherein the 10B medicine is administered to a subject suffering from cancer at a dose of 300-600 mg per administration, and is accumulated after the administration such that the concentration of 10B in the cancer tissue of the subject becomes 1 ppm or higher.Type: ApplicationFiled: June 19, 2019Publication date: May 13, 2021Applicant: HIROSAKI UNIVERSITYInventors: Chikara OHYAMA, Tohru YONEYAMA, Shingo HATAKEYAMA, Shintaro ISHIYAMA
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Patent number: 9933430Abstract: The method for distinguishing between prostate carcinoma and benign prostatic hyperplasia comprising: bringing an analyte sample containing a prostate-specific antigen (PSA) into contact with a carrier having an anti-free PSA antibody immobilized thereon, thereby binding free PSA to the anti-free PSA antibody immobilized on the carrier; thereafter bringing the carrier in which the free PSA is bound to the immobilized anti-free PSA antibody into contact with a monoclonal antibody capable of specifically recognizing a glycan in which a terminal sialic acid residue is bound to galactose through an ?(2,3) bond, thereby binding the monoclonal antibody recognizing the glycan to the free PSA bound to the anti-free PSA antibody; measuring the amount of the free PSA having an N-type glycan in which a terminal sialic acid residue is bound to galactose through an ?(2,3) bond; comparing the measured amount thus obtained with a preset cutoff value for prostate carcinoma and benign prostatic hyperplasia, thereby determininType: GrantFiled: October 9, 2013Date of Patent: April 3, 2018Assignees: HIROSAKI UNIVERSITY, SHIZUOKA PREFECTURAL UNIVERSITY CORPORATIONInventors: Chikara Ohyama, Tohru Yoneyama, Yuki Tobisawa, Shingo Hatakeyama, Takashi Suzuki, Ilpal Jwa, Maho Yamaguchi
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Publication number: 20150260720Abstract: An object of the present invention is to provide a method for distinguishing between prostate carcinoma and benign prostatic hyperplasia with high sensitivity and good reproducibility using a small amount of an analyte sample.Type: ApplicationFiled: October 9, 2013Publication date: September 17, 2015Applicants: HIROSAKI UNIVERSITY, SHIZUOKA PREFECTURAL UNIVERSITY CORPORATIONInventors: Chikara Ohyama, Tohru Yoneyama, Yuki Tobisawa, Shingo Hatakeyama, Takashi Suzuki, Ilpal Jwa, Maho Yamaguchi
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Patent number: 8596621Abstract: A partitioning member partitioning two liquid chambers includes an orifice forming member, an elastic wall configured to close an inner peripheral surface thereof, and a pair of partitioning plates which hold the elastic wall from both sides in an axial direction X The pair of partitioning plates includes a holding portion configured to hold the elastic wall radially outward Ko of a coupling portion. The holding portion comprises a first holding portion on the radially outside and a second holding portion on the radially inside, and the first holding portion is provided with a high-compression holding portion having a compression ratio higher than that of the second holding portion. Accordingly, the abnormal sound is reduced while achieving both the damping performance in the low frequency range and the lowering of the dynamic spring constant in the high-frequency range without impairing the assembleability of the partitioning member.Type: GrantFiled: March 5, 2009Date of Patent: December 3, 2013Assignee: Toyo Tire & Rubber Co., Ltd.Inventors: Dai Ogasawara, Shingo Hatakeyama
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Publication number: 20120309022Abstract: The present invention provides a novel method for diagnosing renal cell carcinoma. The method of the invention allows evaluation of the presence of renal cell carcinoma or the degree of malignancy of renal cell carcinoma, by conducting comprehensive analysis of N-linked sugar chains in serum of a patient and utilizing an expression level of detected sugar chain as an index of the evaluation.Type: ApplicationFiled: September 14, 2010Publication date: December 6, 2012Inventors: Shin-Ichiro Nishimura, Yoshiaki Miura, Taku Nakahara, Maho Amano, Chikara Ohyama, Shingo Hatakeyama
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Publication number: 20110193276Abstract: A partitioning member 40 partitioning two liquid chambers 36A, 36B includes an orifice forming member 44, an elastic wall 46 configured to close an inner peripheral surface 44A thereof, and a pair of partitioning plates 48 and 50 which hold the elastic wall from both sides in an axial direction X. The pair of partitioning plates includes a holding portion 60 configured to hold the elastic wall 46 radially outward Ko of a coupling portion 56. The holding portion comprises a first holding portion 64 on the radially outside and a second holding portion 66 on the radially inside, and the first holding portion 64 is provided with a high-compression holding portion 68 having a compression ratio higher than that of the second holding portion 66. Accordingly, the abnormal sound is reduced while achieving both the damping performance in the low frequency range and the lowering of the dynamic spring constant in the high-frequency range without impairing the assembleability of the partitioning member.Type: ApplicationFiled: March 5, 2009Publication date: August 11, 2011Applicant: TOYO TIRE & RUBBER CO., LTD.Inventors: Dai Ogasawara, Shingo Hatakeyama
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Publication number: 20090224445Abstract: A liquid filled type vibration isolator which can reduce generation of abnormal noise without lowering vibration isolating capability includes a first attachment member 1, a second attachment member 2, a vibration isolating base 3, a diaphragm 9, a partitioning member 12, and an orifice 25. The partitioning member 12 has an annular orifice forming member 16 provided inside of the second attachment member, a rubber wall 15 bonded to an inner circumferential surface 16N of the orifice forming member 16 by vulcanization to close the inside of the inner circumferential surface 16N, and a pair of partitioning plates 17 and 18 between which the rubber wall is sandwiched in an axial direction G. The one partitioning plate 18 constitutes a part of a chamber wall of a first liquid chamber 11A, and the other partitioning plate 17 constitutes a part of a chamber wall of a second liquid chamber 11B.Type: ApplicationFiled: November 17, 2006Publication date: September 10, 2009Applicant: Toyo Tire & Rubber Co., Ltd.Inventors: Shingo Hatakeyama, Dai Ogasawara, Makoto Suzuki
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Patent number: 7516947Abstract: A hydraulic antivibration device capable of sufficiently reducing strange sounds is provided. The one in a first embodiment includes first ribs whose tops are spaced apart from lattice members and second ribs having tops abutting on the lattice members and a smaller rib width than the first ribs. When an elastic partition membrane impinges on the lattice members with vibration, the second ribs resist and the elastic partition membrane impinges moderately on the lattice members, so that strange sounds can be reduced. In a second embodiment, such first and second displacement-regulating protrusions are provided that are disposed asymmetrically relative to a phantom plane passing through a center of the elastic partition membrane in its thickness direction.Type: GrantFiled: March 31, 2004Date of Patent: April 14, 2009Assignee: Toyo Tire & Rubber Co., Ltd.Inventors: Shingo Hatakeyama, Masaaki Itoh, Kentarou Yamamoto, Yasuhiro Tanaka
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Patent number: 7464918Abstract: Provided is a liquid sealing type vibration control device capable of sufficiently reducing strange sounds which comprises a first attachment fitting (1), a second attachment fitting (2), a vibration-isolating base body (3), a diaphragm (9), a partition body (12), and an orifice (25), the partition body (12) including an elastic partition membrane (15) and a pair of lattice members (17, 18). The elastic partition membrane (15) is provided on its both faces with rib groups (50) in a projecting manner, the rib groups (50) each consist of plural first ribs (51) and plural second ribs (52) mingled mutually, the first ribs (51) are set in such a height dimension that their tops can be situated apart from the lattice members (17, 18), and the second ribs (52) are set in such a height dimension that their tops abut on the lattice members (17, 18) and in a smaller rib width than the first ribs (51).Type: GrantFiled: January 9, 2004Date of Patent: December 16, 2008Assignee: Toyo Tire & Rubber Co., Ltd.Inventors: Shingo Hatakeyama, Masaaki Ito, Tomoyoshi Edo
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Publication number: 20060267259Abstract: Provided is a liquid sealing type vibration control device capable of sufficiently reducing strange sounds which comprises a first attachment fitting (1), a second attachment fitting (2), a vibration-isolating base body (3), a diaphragm (9), a partition body (12), and an orifice (25), the partition body (12) including an elastic partition membrane (15) and a pair of lattice members (17, 18). The elastic partition membrane (15) is provided on its both faces with rib groups (50) in a projecting manner, the rib groups (50) each consist of plural first ribs (51) and plural second ribs (52) mingled mutually, the first ribs (51) are set in such a height dimension that their tops can be situated apart from the lattice members (17, 18), and the second ribs (52) are set in such a height dimension that their tops abut on the lattice members (17, 18) and in a smaller rib width than the first ribs (51).Type: ApplicationFiled: January 9, 2004Publication date: November 30, 2006Inventors: Shingo Hatakeyama, Masaaki Ito, Tomoyoshi Edo
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Publication number: 20060071381Abstract: A hydraulic antivibration device capable of sufficiently reducing strange sounds is provided. The one in a first embodiment includes first ribs whose tops are spaced apart from lattice members and second ribs having tops abutting on the lattice members and a smaller rib width than the first ribs. When an elastic partition membrane impinges on the lattice members with vibration, the second ribs resist and the elastic partition membrane impinges moderately on the lattice members, so that strange sounds can be reduced. In a second embodiment, such first and second displacement-regulating protrusions are provided that are disposed asymmetrically relative to a phantom plane passing through a center of the elastic partition membrane in its thickness direction.Type: ApplicationFiled: March 31, 2004Publication date: April 6, 2006Inventors: Shingo Hatakeyama, Masaaki Itoh, Kentarou Yamamoto, Yasuhiro Tanaka
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Patent number: 6910683Abstract: In an anti-vibration device having a partition member dividing a fluid-sealed chamber into upside and downside, aimed at enhancing the anti-vibration performance by preventing unwanted leak of the fluid through through-holes of the partition member. To that end, the partition member is constructed of an elastic membrane partitioning the fluid-sealed chamber, and a pair of grids limiting displacements of the elastic membrane; and the elastic membrane is provided at its either surface with projecting streaks integral therewith, the projecting streaks surrounding through-holes, defined by the grids, over their whole peripheries and abutting on the grids, thereby regulating the flow of fluid among adjacent through-holes.Type: GrantFiled: May 29, 2003Date of Patent: June 28, 2005Assignees: Toyo Tire & Rubber Co., Ltd., Nissan Motor Co., Ltd.Inventors: Masaaki Itoh, Shingo Hatakeyama, Yukio Takashima, Takeshi Hamanaka
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Publication number: 20040239021Abstract: In an anti-vibration device having a partition member dividing a fluid-sealed chamber into upside and downside, aimed at enhancing the anti-vibration performance by preventing unwanted leak of the fluid through through-holes of the partition member. To that end, the partition member is constructed of an elastic membrane partitioning the fluid-sealed chamber, and a pair of grids limiting displacements of the elastic membrane; and the elastic membrane is provided at its either surface with projecting streaks integral therewith, the projecting streaks surrounding through-holes, defined by the grids, over their whole peripheries and abutting on the grids, thereby regulating the flow of fluid among adjacent through-holes.Type: ApplicationFiled: May 29, 2003Publication date: December 2, 2004Applicants: Toyo Tire & Rubber Co., Ltd., Nissan Motor Co., Ltd.Inventors: Masaaki Itoh, Shingo Hatakeyama, Yukio Takashima, Takeshi Hamanaka
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Patent number: 5887844Abstract: A fluid-sealed vibration isolating device comprises primary and secondary damping-fluid chambers, a fluid-flow restrictive plate or diaphragm for dividing the primary damping-fluid chamber into first and second main chambers and being responsive to an amplitude of input vibration for restricting a flow of damping fluid between the first and second main chambers when the amplitude of input vibration is greater than a predetermined amplitude, the secondary damping-fluid chamber including first and second sub-chambers, and first, second and third orifice passageways for defining respective flow restrictive passages between the first main chamber and the first sub-chamber, between the second main chamber and the first sub-chamber, and between the second main chamber and the second sub-chamber.Type: GrantFiled: July 30, 1997Date of Patent: March 30, 1999Assignee: Kinugawa Rubber Ind. Co., Ltd.Inventors: Yoshinari Fujiwara, Shingo Hatakeyama