Patents by Inventor Shingo Kajimura

Shingo Kajimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for induced brown fat differentiation
    Patent number: 11766471
    Abstract: The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of both Prdm16 and C/EBP? activity and/or expression. Also provided are methods for preventing or treating obesity or an obesity related disorder in a subject through stimulation of both Prdm16 and C/EBP? expression and/or activity. Further provided are methods for identifying compounds that are capable of modulating both Prdm16 and C/EBP? expression and/or activity.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: September 26, 2023
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Bruce M. Spiegelman, Shingo Kajimura
  • COMPOSITIONS AND METHODS FOR INDUCED BROWN FAT DIFFERENTIATION
    Publication number: 20200206317
    Abstract: The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of both Prdm16 and C/EBP? activity and/or expression. Also provided are methods for preventing or treating obesity or an obesity related disorder in a subject through stimulation of both Prdm16 and C/EBP? expression and/or activity. Further provided are methods for identifying compounds that are capable of modulating both Prdm16 and C/EBP? expression and/or activity.
    Type: Application
    Filed: December 19, 2019
    Publication date: July 2, 2020
    Inventors: Bruce M. Spiegelman, Shingo Kajimura
  • Compositions, kits, and methods for identification, assessment, prevention, and therapy of metabolic disorders
    Patent number: 10429384
    Abstract: The invention provides methods and compositions for selectively promoting anti-metabolic disorder activity over classical PPAR gamma activation through modulation of PPAR gamma phosphorylation (e.g., Ser-273 phosphorylation of murine peroxisome proliferator activated receptor gamma (PPAR gamma) 2 or a corresponding serine residue in a murine PPAR gamma 2 homolog, including a human). Also provided are methods for preventing, treating, or predictiving responsiveness of therapies for metabolic disorders in a subject through selective inhibition of such PPAR gamma phosphorylation. Further provided are methods for identifying compounds that are capable of modulating such PPAR gamma phosphorylation.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: October 1, 2019
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Bruce M. Spiegelman, Jang Hyun Choi, Shingo Kajimura, Alexander Banks
  • Compositions and Methods for Induced Brown Fat Differentiation
    Publication number: 20160095905
    Abstract: The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of both Prdm1? and C/EBP? activity and/or expression. Also provided are methods for preventing or treating obesity or an obesity related disorder in a subject through stimulation of both Prdm1? and C/EBP? expression and/or activity. Further provided are methods for identifying compounds that are capable of modulating both Prdm1? and C/EBP? expression and/or activity.
    Type: Application
    Filed: October 5, 2015
    Publication date: April 7, 2016
    Inventors: Bruce M. Spiegelman, Shingo Kajimura
  • Compositions and methods for induced brown fat differentiation
    Patent number: 9181315
    Abstract: The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of both Prdm1? and C/EBP? activity and/or expression. Also provided are methods for preventing or treating obesity or an obesity related disorder in a subject through stimulation of both Prdm1? and C/EBP? expression and/or activity. Further provided are methods for identifying compounds that are capable of modulating both Prdm1? and C/EBP? expression and/or activity.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: November 10, 2015
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Bruce M. Spiegelman, Shingo Kajimura
  • Compositions, Kits, and Methods for Identification, Assessment, Prevention, and Therapy of Metabolic Disorders
    Publication number: 20130019326
    Abstract: The invention provides methods and compositions for selectively promoting anti-metabolic disorder activity over classical PPAR gamma activation through modulation of PPAR gamma phosphorylation (e.g., Ser-273 phosphorylation of murine peroxisome proliferator activated receptor gamma (PPAR gamma) 2 or a corresponding serine residue in a murine PPAR gamma 2 homolog, including a human). Also provided are methods for preventing, treating, or predictiving responsiveness of therapies for metabolic disorders in a subject through selective inhibition of such PPAR gamma phosphorylation. Further provided are methods for identifying compounds that are capable of modulating such PPAR gamma phosphorylation.
    Type: Application
    Filed: January 20, 2011
    Publication date: January 17, 2013
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Bruce M. Spiegelman, Jang Hyun Choi, Shingo Kajimura, Alexander Banks
  • Compositions and Methods for Induced Brown Fat Differentiation
    Publication number: 20120022500
    Abstract: The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of both Prdm1? and C/EBP? activity and/or expression. Also provided are methods for preventing or treating obesity or an obesity related disorder in a subject through stimulation of both Prdm1? and C/EBP? expression and/or activity. Further provided are methods for identifying compounds that are capable of modulating both Prdm1? and C/EBP? expression and/or activity.
    Type: Application
    Filed: January 8, 2010
    Publication date: January 26, 2012
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Bruce M. Spiegelman, Shingo Kajimura