Abstract: A novel hemostasis valve-equipped indwelling needle that is capable of discharging air in an internal flow path includes a cannula to be inserted percutaneously into a blood vessel on a distal end side thereof, a link connector on a proximal end side thereof, an internal flow path extending from the cannula to the link connector, and a hemostatic valve disposed inside the link connector. An air vent passage that allows the internal flow path to communicate with an external space is formed in the link connector further on the cannula side than the hemostatic valve, and a filter that allows gas to pass through but does not allow liquid to pass through is mounted in a compressed state on the air vent passage.

Abstract: A needle assembly 10 including: an inner needle 16 with an inner needle hub 18 at its proximal side; a hollow outer needle 58 with an outer needle hub 60 at its proximal side; a needle tip protector 22 protecting a needle tip 20 of the inner needle 16 removed from the outer needle 58; a valve body 80 blocking a lumen of the outer needle hub 60; a pusher 84 pushing a cut 86 of the valve body 80 open by moving toward the needle tip 20 of the inner needle 16 so as to release blockage of the outer needle hub 60 by the valve body 80, the pusher 84 including a push-in piece 108 extending toward a proximal end beside the needle tip protector 22; and a tubular pusher guide 82 guiding movement of the pusher 84 toward the needle tip 20, the pusher guide 82 including an insertion area 96 which allows insertion of the push-in piece 108 therein.

Abstract: The needle tip protector is attached to a puncture needle and prevents exposure of a needle tip by being moved to the needle tip side, and includes a first side plate and a second side plate extending from a bottom part located on a needle base side of the puncture needle to the needle tip side, and facing each other while sandwiching the puncture needle from both sides. The first side plate and the second side plate include lateral cover pieces protruding inward in a direction of facing at respective widthwise edges, which are opposite to each other in a plate width direction. With the needle tip protector attached to the puncture needle, the puncture needle is located between the respective lateral cover pieces of the first side plate and the second side plate.

Abstract: An object of the present invention is to provide a method capable of detecting activity of an enzyme that strictly recognizes a substrate, such as acetylcholinesterase (AChE). There is provided a method for detecting activity of an enzyme in a biological sample using a microdevice, the method including a step of bringing the biological sample into contact with a substrate analog or a natural substrate, and a compound represented by General Formula (I) below or a salt thereof, wherein the substrate analog or the natural substrate generates a compound A having a thiol group (R—SH), a selenol group (R—SeH), or a poly sulfur atom (R—(S)n-H) (R is a hydrogen atom or an alkyl group, and n is 1 to 5) by a reaction with the enzyme, and fluorescence is observed or measured, the fluorescence being emitted or enhanced from a fluorescent product generated by the reaction of the compound represented by General Formula (I) or the salt thereof with the thiol group, the selenol group, or the poly sulfur atom.

Abstract: An objective of the present invention is to provide an indwelling needle assembly that has a novel structure and improves operability for the practitioner. An indwelling needle assembly 10 in which an inner needle unit 16 comprises a storage housing 14 for storing a protector 52, and which is provided with a connecting member 94 that connects the storage housing 14 to an outer needle hub 20. The protector 52 prevents movement of the connecting member 94 and holds the storage housing 14 and the outer needle hub 20 in a connected state. Deformation or displacement of the protector 52 due to retraction of an inner needle 12 permits the movement of the connecting member 94 and makes it possible to release the connected state between the storage housing 14 and the outer needle hub 20.

Abstract: A hub assembly with a hub body connected to a tube from an external appliance, a hub outer casing which is coupled to the hub body and forms a liquid passage, a slitted separating wall disposed in the liquid passage in the hub outer casing, a filter disposed on the living body-side of the separating wall to allow the passage of gas and regulate the passage of liquid, and a ventilation passage which communicates between the liquid passage and the outside of the hub outer casing by way of the filter, wherein an end portion of the ventilation passage on the separating wall side of an opening portion facing the liquid passage is in a location at most 10 mm toward the distal end side relative to the distal end of the separating wall.

Abstract: To provide a synthesis scheme capable of easily synthesizing various kinds of fluorescent probes. A method for preparing a compound represented by Formula (III) below, the method including steps (1) to (5).

Abstract: A novel hemostasis valve-equipped indwelling needle that is capable of discharging air in an internal flow path includes a cannula to be inserted percutaneously into a blood vessel on a distal end side thereof, a link connector on a proximal end side thereof, an internal flow path extending from the cannula to the link connector, and a hemostatic valve disposed inside the link connector. An air vent passage that allows the internal flow path to communicate with an external space is formed in the link connector further on the cannula side than the hemostatic valve, and a filter that allows gas to pass through but does not allow liquid to pass through is mounted in a compressed state on the air vent passage.

Abstract: A novel hemostasis valve-equipped indwelling needle that is capable of discharging air in an internal flow path includes a cannula to be inserted percutaneously into a blood vessel on a distal end side thereof, a link connector on a proximal end side thereof, an internal flow path extending from the cannula to the link connector, and a hemostatic valve disposed inside the link connector. An air vent passage that allows the internal flow path to communicate with an external space is formed in the link connector further on the cannula side than the hemostatic valve, and a filter that allows gas to pass through but does not allow liquid to pass through is mounted in a compressed state on the air vent passage.

Abstract: A voltage divider circuit includes: a first voltage divider having first and second capacitors, and an output node configured to output a divider voltage from between the first and second capacitors; a second voltage divider having third and fourth capacitors, and first to third switches, and being connected in parallel to the first voltage divider; and a fourth switch provided between the output node and a connection node of the third and fourth capacitors. In the voltage divider circuit, the switches are controlled based on controlling periods.

Abstract: Provided is a novel fluorescent probe. A compound of the following general formula (I) or a salt thereof.

Abstract: A valved needle assembly including a needle hub provided to a proximal end side of a hollow needle, and a valve member incorporated therein for blocking communication with the hollow needle. A protrusion protrudes from a distal end side toward a proximal end side inside the needle hub and the valve member blocks the proximal end side of the protrusion inside the needle hub. A central valve part of the valve member having a slit moves toward the protrusion such that the slit is opened and placed in communication by the protrusion. The central valve part includes a distal end tubular part and a proximal end tubular part extending from its outer circumferential portion toward the distal end side and the proximal end side respectively.

Abstract: A voltage divider circuit includes: a first voltage divider having first and second capacitors, and an output node configured to output a divider voltage from between the first and second capacitors; a second voltage divider having third and fourth capacitors, and first to third switches, and being connected in parallel to the first voltage divider; and a fourth switch provided between the output node and a connection node of the third and fourth capacitors. In the voltage divider circuit, the switches are controlled based on controlling periods.

Abstract: A drug solution injection controller 10 includes a sub-reservoir 24 connected via a sub-line 26 to a main line 14 for performing continuous administration of a drug solution such that rapid administration of the drug solution from the sub-reservoir 24 by self-operation is enabled, and comprises: a priming flow path 46 configured to perform priming on at least one of the main line 14 and the sub-line 26; a closing mechanism 48 configured to close the priming flow path 46; and a connector holding part 84 holding a terminal connector 18 connected to the main line 14. Holding of the terminal connector 18 by the connector holding part 84 is allowed to be released due to operation of an operation switch 50 configured to activate the closing mechanism 48.

Abstract: An objective of the present invention is to provide an indwelling needle assembly that has a novel structure and improves operability for the practitioner. An indwelling needle assembly 10 in which an inner needle unit 16 comprises a storage housing 14 for storing a protector 52, and which is provided with a connecting member 94 that connects the storage housing 14 to an outer needle hub 20. The protector 52 prevents movement of the connecting member 94 and holds the storage housing 14 and the outer needle hub 20 in a connected state. Deformation or displacement of the protector 52 due to retraction of an inner needle 12 permits the movement of the connecting member 94 and makes it possible to release the connected state between the storage housing 14 and the outer needle hub 20.

Abstract: This needle assembly is provided with a needle having a needle tip, a needle hub, and a protector. The protector is displaceable between a non-protection position at which the needle is exposed and a protection position at which the needle tip is covered; has an opening formed elongated to match the needle, and includes a main body and a claw-like portion. The needle enters the main body from the opening to cover the needle tip when the protector is displaced to the protection position. The claw-like portion is bent by the needle when the protector is displaced to the protection position, allows the needle to advance into the main body, and is elastically restored to lock the needle when the needle enters the main body. The claw-like portion projects obliquely from the main body, extends across the opening in the width direction, and extends in the longitudinal direction.

Abstract: A medical valve which is able to more reliably support an outer peripheral part of an elastic valve body with respect to a housing, and prevent a problem of the elastic valve body becoming dislodged inward. A medical valve includes an elastic valve body with annular grooves formed thereon and a tubular support part formed at an outer peripheral side of an annular joining part positioned between the annular grooves. Inside and outside holding parts engage the annular grooves provided to the valve inside and outside surfaces of the annular joining part. The outside holding part and inside holding part are provided to an opening member, and with the tubular support part, a part projecting inward in an axial direction is sandwiched and supported between the inside holding part and outside holding part.

Abstract: A valved needle assembly including a needle hub provided to a proximal end side of a hollow needle, and a valve member incorporated therein for blocking communication with the hollow needle. A protrusion protrudes from a distal end side toward a proximal end side inside the needle hub and the valve member blocks the proximal end side of the protrusion inside the needle hub. A central valve part of the valve member having a slit moves toward the protrusion such that the slit is opened and placed in communication by the protrusion. The central valve part includes a distal end tubular part and a proximal end tubular part extending from its outer circumferential portion toward the distal end side and the proximal end side respectively.

Abstract: A hub assembly with a hub body connected to a tube from an external appliance, a hub outer casing which is coupled to the hub body and forms a liquid passage, a slitted separating wall disposed in the liquid passage in the hub outer casing, a filter disposed on the living body-side of the separating wall to allow the passage of gas and regulate the passage of liquid, and a ventilation passage which communicates between the liquid passage and the outside of the hub outer casing by way of the filter, wherein an end portion of the ventilation passage on the separating wall side of an opening portion facing the liquid passage is in a location at most 10 mm toward the distal end side relative to the distal end of the separating wall.

Abstract: A receiving unit receives an execution request for an internal application from an external device. A determining unit determines whether the external device that has transmitted the execution request is set as a communication target of the internal application for which the execution request has been received. If it has been determined that the external device is set as the communication target, a verifying unit verifies a version of the external application executed in the external device. If the verified version is no earlier than a threshold, an execution controlling unit executes the internal application. If the verified version is older than the threshold, an informing unit issues a warning.