Patents by Inventor Shinichi Hiroshima

Shinichi Hiroshima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for damaging cells using effector functions of anti-EphA4 antibodies
    Patent number: 8003098
    Abstract: The present invention relates to the use of cytoxicity based on the effector function of anti-EphA4 antibodies. Specifically, the present invention provides methods and pharmaceutical compositions that comprise an anti-EphA4 antibody as an active ingredient for damaging EphA4-expressing cells using antibody effector function. Since EphA4 is strongly expressed in pancreatic cancer cells, the present invention is particularly useful in pancreatic cancer therapies.
    Type: Grant
    Filed: February 22, 2007
    Date of Patent: August 23, 2011
    Assignee: Oncotherapy Science, Inc.
    Inventors: Shuichi Nakatsuru, Megumi Yoshikawa, Shinichi Hiroshima, Yoshiro Kishi, Motoki Kuhara, Shiyo Nishida, Midori Shinohara
  • METHODS FOR DAMAGING CELLS USING EFFECTOR FUNCTIONS OF ANTI-EphA4 ANTIBODIES
    Publication number: 20090191211
    Abstract: The present invention relates to the use of cytoxicity based on the effector function of anti-EphA4 antibodies. Specifically, the present invention provides methods and pharmaceutical compositions that comprise an anti-EphA4 antibody as an active ingredient for damaging EphA4-expressing cells using antibody effector function. Since EphA4 is strongly expressed in pancreatic cancer cells, the present invention is particularly useful in pancreatic cancer therapies.
    Type: Application
    Filed: February 22, 2007
    Publication date: July 30, 2009
    Applicant: Oncotherapy Science, Inc.
    Inventors: Shuichi Nakatsuru, Megumi Yoshikawa, Shinichi Hiroshima
  • METHODS FOR DAMAGING CELLS USING EFFECTOR FUNCTIONS OF ANTI-CDH3 ANTIBODIES
    Publication number: 20090169572
    Abstract: The present invention relates to the use of cytotoxicity based on the effector function of anti-CDH3 antibodies. Specifically, the present invention provides methods and pharmaceutical compositions that comprise an anti-CDH3 antibody as an active ingredient for damaging CDH3-expressing cells using antibody effector function. Since CDH3 is strongly expressed in pancreatic, lung, colon, prostate, breast, gastric or liver cancer cells, the present invention is useful in pancreatic, lung, colon, prostate, breast, gastric or liver cancer therapies.
    Type: Application
    Filed: February 28, 2007
    Publication date: July 2, 2009
    Applicant: Oncotherapy Science, Inc,
    Inventors: Shuichi Nakatsuru, Megumi Yoshikawa, Shinichi Hiroshima
  • Specific base sequence detection method and primer extension reaction detection method
    Publication number: 20060105366
    Abstract: A specific base sequence detection method, comprising preparing a sample solution including a target nucleic acid, a primer for amplifying a specific base sequence and whose end has a site to be coupled to an electrode, and nucleotide; extending the primer if the specific base sequence is present in the nucleic acid by putting the sample solution in a condition that causes an extension reaction of the primer; performing an electrical measurement by immersing an electrode in a measurement solution including the sample solution that has completed the extension reaction; and detecting whether the specific base sequence is present in the nucleic acid based on a result of the electrical measurement.
    Type: Application
    Filed: October 13, 2005
    Publication date: May 18, 2006
    Applicant: Seiko Epson Corporation
    Inventors: Shinichi Hiroshima, Hiroshi Takiguchi, Hitoshi Fukushima, Shinobu Yokokawa