Patents by Inventor Shinichi Ikushiro

Shinichi Ikushiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing glucuronic acid conjugate using
    Patent number: 8741602
    Abstract: Provided is a new method for producing a glucuronide, having excellent productivity and being replaceable with a method using Saccharomyces pombe, and to provide a new means used in this production method. Disclosed are: a transformed Saccharomyces cerevisiae wherein a gene coding for a UDP-glucose dehydrogenase and a gene coding for a UDP-glucose transferase are inserted in a manner such that said genes can be expressed; a transformed Saccharomyces cerevisiae wherein a gene coding for a cytochrome P450 gene is further inserted in a manner such that said gene can be expressed; and a method for producing a glucaronide that includes culturing transformed Saccharomyces cerevisiae in the presence of glucose and a substance to be conjugated, generating the glucuronide of the aforementioned substance to be conjugated.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: June 3, 2014
    Assignees: Toyama Prefecture, Topu Bio Research Co., Ltd.
    Inventors: Shinichi Ikushiro, Toshiyuki Sakaki, Kaori Yasuda
  • METHOD FOR PRODUCING GLUCURONIC ACID CONJUGATE USING SACCHAROMYCES CEREVISIAE
    Publication number: 20130059341
    Abstract: Provided is a new method for producing a glucuronide, having excellent productivity and being replaceable with a method using Saccharomyces pombe, and to provide a new means used in this production method. Disclosed are: a transformed Saccharomyces cerevisiae wherein a gene coding for a UDP-glucose dehydrogenase and a gene coding for a UDP-glucose transferase are inserted in a manner such that said genes can be expressed; a transformed Saccharomyces cerevisiae wherein a gene coding for a cytochrome P450 gene is further inserted in a manner such that said gene can be expressed; and a method for producing a glucaronide that includes culturing transformed Saccharomyces cerevisiae in the presence of glucose and a substance to be conjugated, generating the glucuronide of the aforementioned substance to be conjugated.
    Type: Application
    Filed: February 14, 2011
    Publication date: March 7, 2013
    Applicant: Toyama Prefecture
    Inventors: Shinichi Ikushiro, Toshiyuki Sakaki, Kaori Yasuda