Abstract: According to a conventional method for treatment of Sandhoff disease and Tay-Sachs disease comprising administering a modified ?-subunit to a patient in the form of a protein, it is necessary that administration be performed frequently. This invention relates to a recombinant adeno-associated virus virion comprising: capsomere comprising a protein capable of forming a virus virion; and a polynucleotide packaged in the capsomere comprising a promoter sequence and nucleotide sequences operably linked to the promoter sequence encoding a first amino acid sequence derived from the amino acid sequence of the ?-subunit of wild-type human ?-hexosaminidase composed of amino acids 55 to 556 in the sequence as shown in SEQ ID NO: 28 by substitution of amino acids 312 to 318 with glycine, serine, glutamic acid, proline, serine, glycine, and threonine in that order and a second amino acid sequence, which is an amino acid sequence of a signal peptide linked to the N terminus of the first amino acid.

Abstract: An electromagnetic valve manifold includes an electromagnetic valve and a manifold base. The electromagnetic valve includes a manual shaft. The manual shaft is configured to be manually operated to be switched between a first switching position, in which the manual shaft allows movement of the valve member relative to the valve hole, and a second switching position in which the manual shaft restricts movement of the valve member relative to the valve hole. The manual shaft includes a projection that is projected into and retracted from the valve hole. The valve member includes at least one recess in an outer surface of the valve member. The manual shaft is configured such that, in a state in which the manual shaft is located in the second switching position, the projection is projected into the valve hole and engaged with the recess, so as to restrict movement of the valve member.

Abstract: Provided is a liquid ejection apparatus, liquid ejection method, dispensing apparatus, and compound introduction apparatus capable of inhibiting contamination of a liquid after being ejected. The liquid ejection apparatus has an ejection unit having an ejection part and an ejection energy generation element that ejects a liquid from the ejection part by using a principle of inkjet ejection into an internal space in a storage part capable of storing the ejected liquid. When ejecting the liquid, the ejection unit covers an opening portion of the storage part to thereby screen the internal space in the storage part from an external space.

Abstract: A sheet feed device comprises a main body section, a support section, a first link, a second link, an engagement mechanism, an energization section and a correcting section. The correcting section is movable in an approaching position at which the support section approaches the main body section against energization force of the energization section while being contactable with the second link in a direction in which the first link moves to a downstream side in the conveyance direction, and is movable in a separation position at which the support section is separated from the main body section while being separable from the second link in a direction in which the first link moves to an upstream side in the conveyance direction.

Abstract: An image forming apparatus includes: a rotating member to heat a toner on a sheet; a heater to heat the rotating member; a power controller to maintain temperature of the rotating member in a first mode after the temperature reaches the target temperature, and configured to raise the temperature to the target temperature in a second mode after the temperature falls under the target temperature; a waste toner container to store a waste toner; an agitator to agitate the waste toner in the waste toner container; an driver to rotate the agitator a number of times in a drive if the heat controller stops to raise the temperature in the second mode; a counter to count a number of the drives; and an agitation controller to set the number of times in the drive based on the number of the drives.

Abstract: Disclosed is a toner recycle device for supplying recovered toner into a developing device again and reusing it. The ratio of the amount of the recovered toner to be supplied into the developing device to the amount of new toner is arbitrarily increased or reduced. Further, as the remaining amount of the new toner reduces, one or a plurality of the following three processing steps of a toner save mode are executed: (1) to increase the ratio of the amount of the recovered toner, which is supplied into the developing device, to the amount of the new toner; (2) to reduce the total amount of the recovered toner and the new toner to be supplied; and (3) to stop the new toner to be supplied into the developing device and to supply only the recovered toner. Furthermore, an ordinary mode and the toner save mode are automatically switched or arbitrarily switched manually.

Abstract: A sheet collection apparatus has a stacking portion to stack mails in the standing position, a back-up plate in contact with one end of stacked mails in the stacked direction, and take-in rollers arranged at the positions contacting the other end of stacked mails. The take-in rollers are rotated at a slower peripheral speed than the conveying speed of mails taken in the stacking portion.

Abstract: Disclosed is a toner recycle device for supplying recovered toner into a developing device again and reusing it. The ratio of the amount of the recovered toner to be supplied into the developing device to the amount of new toner is arbitrarily increased or reduced. Further, as the remaining amount of the new toner reduces, one or a plurality of the following three processing steps of a toner save mode are executed: (1) to increase the ratio of the amount of the recovered toner, which is supplied into the developing device, to the amount of the new toner; (2) to reduce the total amount of the recovered toner and the new toner to be supplied; and (3) to stop the new toner to be supplied into the developing device and to supply only the recovered toner. Furthermore, an ordinary mode and the toner save mode are automatically switched or arbitrarily switched manually.

Abstract: A bottle unit (30) of a liquid atomizing apparatus is provided with: a bottle section (31) reserving a chemical liquid (L); a horn oscillating member (40) to whose a distal end the liquid (L) in the bottle section (31) is fed; and a mesh member (1) having a number of fine pores (2), and mounted to an end surface of the distal end (41) of the horn oscillating member (40) in contact therewith. The bottle section (31) is constituted of a large capacity section (B) and a small capacity section (b) in communication with the large capacity section (B) through an opening (32), and opposing to the distal end (41) of the horn oscillating member (40). The small capacity section (b) is formed such that the liquid (L?) therein is in contact with a point in the proximity of the contact section between the distal end (41) of the horn oscillating member (40) and the mesh member (1).

Abstract: A stamp apparatus having a conveying belt pair for conveying a mail matter in an arrow T direction, sensor for detecting the conveyed mail matter, a stamp hub which roll-contacts a postage stamp portion of the mail matter, rotates, and stamps the portion with a postmark, and a backup roller for pressing the conveyed mail matter onto the stamp hub. The stamp hub is directly connected to the AC servo motor, and is rotated at a speed equal to a conveying speed of the mail matter, when a effective region contacts the mail matter.

Abstract: Disclosed is a toner recycle device for supplying recovered toner into a developing device again and reusing it. The ratio of the amount of the recovered toner to be supplied into the developing device to the amount of new toner is arbitrarily increased or reduced. Further, as the remaining amount of the new toner reduces, one or a plurality of the following three processing steps of a toner save mode are executed: (1) to increase the ratio of the amount of the recovered toner, which is supplied into the developing device, to the amount of the new toner; (2) to reduce the total amount of the recovered toner and the new toner to be supplied; and (3) to stop the new toner to be supplied into the developing device and to supply only the recovered toner. Furthermore, an ordinary mode and the toner save mode are automatically switched or arbitrarily switched manually.

Abstract: The conveying apparatus has drive rollers and driven rollers that are opposing each other with the conveying path put between them. The driven rollers are in the dual layers structure comprising rubbers and sponges and are arranged rigidly to the drive rollers that are rigidly arranged at a prescribed center distance. When postal matters are rushed into the nips, the driven rollers are elastically deformed to follow the postal matters.

Abstract: Disclosed is a toner recycle device for supplying recovered toner into a developing device again and reusing it. The ratio of the amount of the recovered toner to be supplied into the developing device to the amount of new toner is arbitrarily increased or reduced. Further, as the remaining amount of the new toner reduces, one or a plurality of the following three processing steps of a toner save mode are executed: (1) to increase the ratio of the amount of the recovered toner, which is supplied into the developing device, to the amount of the new toner; (2) to reduce the total amount of the recovered toner and the new toner to be supplied; and (3) to stop the new toner to be supplied into the developing device and to supply only the recovered toner. Furthermore, an ordinary mode and the toner save mode are automatically switched or arbitrarily switched manually.

Abstract: A developer cartridge which is rotatably mounted in the developing unit of an image forming apparatus, and supplies a developer to the developing unit while rotating includes a cylindrical cartridge main body having a developer outlet hole in the outer surface near one end, and a ring-like cartridge-side shutter which is fitted on the outer surface near one end of the cylindrical cartridge main body to be movable along the rotating shaft of the cylindrical cartridge main body between a position where the developer outlet hole is opened and a position where the developer outlet hole is closed. The developing unit has a guide for inserting the developer cartridge and a driving unit for rotating the developer cartridge, and the guide has a main body-side shutter with a hole.

Abstract: A method and apparatus for discriminating bottle types, for stirring the toner, and for detecting the amount of toner remaining in the toner bottle. A toner bottle is adapted to fit the apparatus for discriminating toner bottle types, and a toner bottle is adapted for the apparatus for stirring toner. The genuineness of the toner bottle product is checked by sensing a rib assumed to be formed with a predetermined length on the outer surface of the toner bottle. Toner is stirred by continuously rotating the toner bottle in forward and reverse directions. The toner bottle can be easily rotated in the forward and reverse directions by sensing the rib of the toner bottle by using the sensor. Since the load of rotation of the toner bottle changes in accordance with the amount of remaining toner, the rotational speed of the toner bottle is sensed by using the sensor to check whether toner is close to empty.

Abstract: A developer cartridge which is rotatably mounted in the developing unit of an image forming apparatus, and supplies a developer to the developing unit while rotating includes a cylindrical cartridge main body having a developer outlet hole in the outer surface near one end, and a ring-like cartridge-side shutter which is fitted on the outer surface near one end of the cylindrical cartridge main body to be movable along the rotating shaft of the cylindrical cartridge main body between a position where the developer outlet hole is opened and a position where the developer outlet hole is closed. The developing unit has a guide for inserting the developer cartridge and a driving unit for rotating the developer cartridge, and the guide has a main body-side shutter with a hole.

Abstract: A method and apparatus for discriminating bottle types, for stirring the toner, and for detecting the amount of toner remaining in the toner bottle. A toner bottle is adapted to fit the apparatus for discriminating toner bottle types, and a toner bottle is adapted for the apparatus for stirring toner. The genuineness of the toner bottle product is checked by sensing a rib assumed to be formed with a predetermined length on the outer surface of the toner bottle. Toner is stirred by continuously rotating the toner bottle in forward and reverse directions. The toner bottle can be easily rotated in the forward and reverse directions by sensing the rib of the toner bottle by using the sensor. Since the load of rotation of the toner bottle changes in accordance with the amount of remaining toner, the rotational speed of the toner bottle is sensed by using the sensor to check whether toner is close to empty.

Abstract: A method and apparatus for discriminating bottle types, for stirring the toner, and for detecting the amount of toner remaining in the toner bottle. A toner bottle is adapted to fit the apparatus for discriminating toner bottle types, and a toner bottle is adapted for the apparatus for stirring toner. The genuineness of the toner bottle product is checked by sensing a rib assumed to be formed with a predetermined length on the outer surface of the toner bottle. Toner is stirred by continuously rotating the toner bottle in forward and reverse directions. The toner bottle can be easily rotated in the forward and reverse directions by sensing the rib of the toner bottle by using the sensor. Since the load of rotation of the toner bottle changes in accordance with the amount of remaining toner, the rotational speed of the toner bottle is sensed by using the sensor to check whether toner is close to empty.

Abstract: A method and apparatus for discriminating bottle types, for stirring the toner, and for detecting the amount of toner remaining in the toner bottle. A toner bottle is adapted to fit the apparatus for discriminating toner bottle types, and a toner bottle is adapted for the apparatus for stirring toner. The genuineness of the toner bottle product is checked by sensing a rib assumed to be formed with a predetermined length on the outer surface of the toner bottle. Toner is stirred by continuously rotating the toner bottle in forward and reverse directions. The toner bottle can be easily rotated in the forward and reverse directions by sensing the rib of the toner bottle by using the sensor. Since the load of rotation of the toner bottle changes in accordance with the amount of remaining toner, the rotational speed of the toner bottle is sensed by using the sensor to check whether toner is close to empty.

Abstract: A method and apparatus for discriminating bottle types, for stirring the toner, and for detecting the amount of toner remaining in the toner bottle. A toner bottle is adapted to fit the apparatus for discriminating toner bottle types, and a toner bottle is adapted for the apparatus for stirring toner. The genuineness of the toner bottle product is checked by sensing a rib assumed to be formed with a predetermined length on the outer surface of the toner bottle. Toner is stirred by continuously rotating the toner bottle in forward and reverse directions. The toner bottle can be easily rotated in the forward and reverse directions by sensing the rib of the toner bottle by using the sensor. Since the load of rotation of the toner bottle changes in accordance with the amount of remaining toner, the rotational speed of the toner bottle is sensed by using the sensor to check whether toner is close to empty.