Abstract: The present invention provides a composition effective in improving symptoms of autism spectrum disorder. The composition contains at least one pyridoxamine compound selected from the group consisting of pyridoxamine and pharmaceutically acceptable salts thereof as an active substance. The composition may be used in combination with at least one thiamine compound selected from the group consisting of thiamine, derivatives thereof, and pharmaceutically acceptable salts thereof.

Abstract: The present invention provides a composition effective in improving symptoms of autism spectrum disorder. The composition contains at least one pyridoxamine compound selected from the group consisting of pyridoxamine and pharmaceutically acceptable salts thereof as an active substance. The composition may be used in combination with at least one thiamine compound selected from the group consisting of thiamine, derivatives thereof, and pharmaceutically acceptable salts thereof.

Abstract: A vehicle including an energy stocking mechanism having an elastic member connected to the driving wheel of the vehicle so that power of the driving wheel is stocked as elastic force in the elastic member and the stocked elastic force is output as power to the driving wheel, and an output limiter that holds the energy stocking mechanism when the elastic force is stocked in the elastic member and releases the holding of the energy stocking mechanism to output the elastic force when the vehicle starts running. A power stocking source for stocking elastic force into the energy stocking mechanism is installed in the vehicle or a station at which the vehicle stops, and connected to the energy stocking mechanism so that power from the power stocking source is applied to the energy stocking mechanism and stocked as the elastic force in the energy stocking mechanism.

Abstract: A vehicle including an energy stocking mechanism having an elastic member connected to the driving wheel of the vehicle so that power of the driving wheel is stocked as elastic force in the elastic member and the stocked elastic force is output as power to the driving wheel, and an output limiter that holds the energy stocking mechanism when the elastic force is stocked in the elastic member and releases the holding of the energy stocking mechanism to output the elastic force when the vehicle starts running. A power stocking source for stocking elastic force into the energy stocking mechanism is installed in the vehicle or a station at which the vehicle stops, and connected to the energy stocking mechanism so that power from the power stocking source is applied to the energy stocking mechanism and stocked as the elastic force in the energy stocking mechanism.

Abstract: There are disclosed a method and device for polishing a metal ring, which is capable of polishing a side edge of the metal ring without performing barrel polishing or polishing by grinding stones. Subsequently to a projecting step of projecting a metal ring W by clearing means 6, a first brush polishing step of polishing one edge of the metal ring W by a polishing brush 60 is performed. Subsequently, an inverting step of inverting the metal ring W whose one edge is polished by the first brush polishing step is inverted by the inverting means 10 is performed. Subsequently, a second brush polishing step of polishing the other edge of the metal ring W which is inverted by the inverting step by the polishing brush 60 is performed. Moreover, a clearing step of clearing the metal ring whose other edge is polished by the second brush polishing step by clearing means 7 is performed.

Abstract: There are disclosed a method and device for polishing a metal ring, which is capable of polishing a side edge of the metal ring without performing barrel polishing or polishing by grinding stones. Subsequently to a projecting step of projecting a metal ring W by clearing means 6, a first brush polishing step of polishing one edge of the metal ring W by a polishing brush 60 is performed. Subsequently, an inverting step of inverting the metal ring W whose one edge is polished by the first brush polishing step is inverted by the inverting means 10 is performed. Subsequently, a second brush polishing step of polishing the other edge of the metal ring W which is inverted by the inverting step by the polishing brush 60 is performed. Moreover, a clearing step of clearing the metal ring whose other edge is polished by the second brush polishing step by clearing means 7 is performed.

Abstract: It is intended to provide a peptide chemically modified with PEG which contains a sequence consisting of 18 amino acids and having a specific structure made up of four planes, i.e., two hydrophobic planes and two hydrophilic planes alternately arranged in an alpha-helix structural model; a complex of the above peptide with a peptide-binding substance; a carrier modified with the peptide chemically modified with PEG as described above; a process for producing the same; and a method of delivering a substance bonded to a carrier modified with the peptide chemically modified with PEG or enclosed therein. The peptide chemically modified with PEG as described above has a high safety and can be easily formulated into a complex with a peptide-binding substance (i.e., having favorable handling properties). The resultant complex has a high solubility and shows an excellent introduction selectivity of the peptide-binding substance into cells.

Abstract: Peptides which are capable of binding to a gene and transferring this gene into cells, have an affinity with phosphatidylserine, have a high safety and an excellent selectivity, can be easily formulated into a complex with the gene and can serve as a vector having a high gene transfer efficiency into cells.

Abstract: Drugs in which peptides having affinity specific for phospholipids, preferably those which are contained in the constituents of lipid bilayers forming the surface layers of cells and of which the proportion in the outer part of each lipid bilayer increases when the cell is not normal, for example, in the case where it is damaged, denatured or activated, and biologically active substances bind to each other, deoxyribonucleic acid (DNA) which codes for the amino acid sequence of the drug in the case where the biologically active substance is a peptide, and processes for producing such drugs. The drugs and novel peptides are useful as preventives and therapeutics of diseases involving coagulopathy, inflammations and immune response.

Abstract: Drugs in which peptides having affinity specific for phospholipids, preferably those which are contained in the constituents of lipid bilayers forming the surface layers of cells and of which the proportion in the outer part of each lipid bilayer increases when the cell is not normal, for example, in the case where it is damaged, denatured or activated, and biologically active substances bind to each other, deoxyribonucleic acid (DNA) which codes for the amino acid sequence of the drug in the case where the biologically active substance is a peptide, and processes for producing such drugs. The drugs and novel peptides are useful as preventives and therapeutics of diseases involving coagulopathy, inflammations and immune response.

Abstract: An apparatus for accommodating a photographic document comprises a web member; a first roller to which one end of the web member is fixed; and a driving force transmitting means for rotating the first roller to wind up the web member thereon so that the photographic document is wound around the first roller together with the web member.

Abstract: In a method of reprinting an image on a frame of a film piece among plural film pieces received with a printing order onto a photographic paper, the plural film pieces are incorporated into a film assemblage without splicing the plural film pieces with no consideration whether each of the plural film pieces has a frame to be reprinted; the plural film pieces are fed out of the film assemblage; the image of the film piece among the plural film pieces fed from the film assemblage is exposed onto the photographic paper; and the exposed photographic paper is developed so as to obtain a visual image.

Abstract: In multi-spindle head-replacing type machine tool comprising a machining unit disposed on a base for advancing and retreating movements between an original position and a machining position, a first annular guide rail including a movable rail integral with the machining unit and a stationary rail to surround the machining unit which is located in the original position, a second annular guide rail disposed concentrically with and at a place axially offset from the first guide rail, a plurality of multi-spindle heads travellably carried on each of the first and second guide rails, first and second index mechanisms releasably connected respectively to the multi-spindle heads on the first and second guide rails for driving such multi-spindle heads for angular displacement, and an elevator mechanism disposed sideways from the first and second guide rails at a place offset from the movable rail for providing replacement of the multi-spindle heads between the first and second guide rails, a part of the stationary ra