Abstract: Provided is an oligonucleic acid analog which contains, as at least one structural unit thereof, a modified nucleic acid monomer compound which is a ring-open nucleoside having a cleaved carbon-carbon bond between the 2? and 3? positions and a substituent hydroxymethyl group at the 4? position. When used as siRNA, the oligonucleic acid analog exhibits superior biological stability and target gene expression inhibiting activity. The oligonucleic acid analog can be used in antisense methods, ribozyme methods, and decoy methods, etc., can be used as a nucleic acid aptamer, and can also be used as a nucleic acid probe or molecular beacon, etc., or in genetic diagnostics, etc.

Abstract: Provided is an oligonucleic acid analog which contains, as at least one structural unit thereof, a modified nucleic acid monomer compound which is a ring-open nucleoside having a cleaved carbon-carbon bond between the 2? and 3? positions and a substituent hydroxymethyl group at the 4? position. When used as siRNA, the oligonucleic acid analog exhibits superior biological stability and target gene expression inhibiting activity. The oligonucleic acid analog can be used in antisense methods, ribozyme methods, and decoy methods, etc., can be used as a nucleic acid aptamer, and can also be used as a nucleic acid probe or molecular beacon, etc., or in genetic diagnostics, etc.

Abstract: The present invention provides an indole derivative having a melanin-concentrating hormone receptor antagonistic action, which is useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract: The present invention provides an indole derivative having a melanin-concentrating hormone receptor antagonistic action, which is useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is C1-6 alkyl or C1-6 haloalkyl; n is 0, 1 or 2; X is (1) group of —NR2R3 wherein R2 and R3 independently represent (i) hydrogen or (ii) C1-6 alkyl which may optionally be substituted with pyridyl, (2) group of —N═CHOR4 wherein R4 represents C1-6 alkyl, (3) group of —N═CHNR6R7 wherein R6 and R7 independently represent (i) hydrogen or (ii) C1-6 alkyl, (4) group of —N═CHAr wherein Ar represents phenyl which may optionally be substituted with substituents selected from the group consisting of hydroxy and C1-3 alkoxy, or (5) pyrrolyl; R5 is optionally substituted alkyl or optionally substituted acyl; R8 is (1) halogen, (2) C1-6 haloalkyl, (3) C1-6 haloalkoxy or (4) phenyl which may optionally be substituted with C1-6 haloalkyl; A is (1) nitrogen atom or (2) group of wherein R9 is chlorine atom or cyano; and B is nitrogen atom or or a sa