Patents by Inventor Shinichi Takimoto
Shinichi Takimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11493745Abstract: A cell observation system according to the present invention includes: a first image-acquisition device disposed in an incubator and acquires a first image of cells in a culturing vessel; a second image-acquisition device disposed outside the incubator; a processing device connected to the first image-acquisition device and the second image-acquisition device; and a display displays at least a region of the first image, as well as the second image. The second image-acquisition device includes a second image-acquisition unit that acquires a second image of the interior of the culturing vessel, that removed from the incubator. The processing device extracts target cells in the first image, calculates positions at which the extracted target cells are present and stores the positions in the memory, and causes the display to display the positions at which the target cells are present in a superimposed manner on an indication indicating the culturing vessel.Type: GrantFiled: December 22, 2019Date of Patent: November 8, 2022Assignee: Evident CorporationInventors: Takashi Miyoshi, Shinichi Takimoto, Yasunobu Iga, Shintaro Takahashi
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Patent number: 11461892Abstract: A cell observation system according to the present invention includes: a first image-acquisition device disposed in an incubator and acquires a first image of cells in a culturing vessel; a second image-acquisition device disposed outside the incubator; a processing device connected to the first and second image-acquisition devices; and a display. The second image-acquisition device includes a second image-acquisition unit that acquires a second image of the interior of the culturing vessel that removed from the incubator, a support that supports the second image-acquisition unit and the culturing vessel, and a position measuring unit that measures a position between the culturing vessel and the second image-acquisition unit at the time of acquiring the second image. The processing device extracts target cells in the first image, calculates positions of the target cells, and displays the relationship between the positions of the target cells and the second image.Type: GrantFiled: December 22, 2019Date of Patent: October 4, 2022Assignee: Evident CorporationInventors: Takashi Miyoshi, Shinichi Takimoto, Yasunobu Iga, Shintaro Takahashi
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Patent number: 11348350Abstract: An observation system includes a processor. The processor manages a plurality of images acquired in time series with respect to a biological sample which is being cultured, records a first comment and a first region of interest (RoI) in a storage device in association with the images based on user's instructions, and records a second comment and a second ROI in the storage device in association with the first comment based on user's instructions.Type: GrantFiled: February 10, 2020Date of Patent: May 31, 2022Assignee: OLYMPUS CORPORATIONInventors: Shinichi Takimoto, Yohei Tanikawa, Taiji Mine, Takayuki Nakatomi, Masakazu Fujii
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Patent number: 11226476Abstract: An observation apparatus including: a top plate on which a container in which a specimen is accommodated can be placed, and through which illumination light can pass; a light source that emits the illumination light upward from below the specimen; an objective lens that focuses, below the specimen and the top plate, transmitted light which is the illumination light that has passed through the specimen from thereabove and that has passed through the top plate; and a camera that captures the transmitted light, wherein the light source emits the illumination light toward an area above the specimen from outside the objective lens in a radial direction, and the top plate is provided with a mark that specifies a viewing-field area of the camera.Type: GrantFiled: March 27, 2019Date of Patent: January 18, 2022Assignee: OLYMPUS CORPORATIONInventors: Tsuyoshi Mochizuki, Shintaro Takahashi, Akira Matsushita, Yohei Tanikawa, Masaru Mizunaka, Shinichi Takimoto
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Patent number: 11194145Abstract: An image reproducing device includes one or more processors. The processor acquires image group data including a plurality of images and tag information on at least one tag. The images relate to a biological sample along time series. The tag information relates to an operation on the biological sample and is associated with at least part of the images. The processor selects from the plurality of images using the tag information, images to be reproduced along the time series as reproduction selected images. The processor outputs to a display, data relating to the images for the reproduction selected images to be reproduced along time series.Type: GrantFiled: November 8, 2019Date of Patent: December 7, 2021Assignee: OLYMPUS CORPORATIONInventors: Yohei Tanikawa, Shinichi Takimoto, Masakazu Fujii, Taiji Mine, Takayuki Nakatomi
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Patent number: 11137588Abstract: An observation apparatus including: a light-source that emits illumination light and excitation light upward from below a specimen; and an image-capturing optical system having an objective lens that focuses, below the specimen, transmitted light, which is the illumination light that is emitted from the light-source, that is reflected above the specimen, and that has passed through the specimen, and fluorescence that is generated in the specimen that has been irradiated with the excitation light emitted from the light-source, wherein the light-source is disposed radially outside the objective lens.Type: GrantFiled: March 26, 2019Date of Patent: October 5, 2021Assignee: OLYMPUS CORPORATIONInventors: Masaru Mizunaka, Shintaro Takahashi, Akira Matsushita, Yohei Tanikawa, Tsuyoshi Mochizuki, Shinichi Takimoto
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Patent number: 11037293Abstract: A cell observation system includes an imaging element that acquires images of the inside of a culture container in which cells are cultured, the imaging element acquiring the images over time; a computer configured to: quantitatively analyze a culture state of the cells cultured in the culture container on the basis of each of the images acquired by the imaging element; and statistically analyze the quantitatively analyzed data; and a display that displays statistical analysis results in the culture container within a plurality of subculture periods obtained by the computer in a manner allowing comparison of the statistical analysis results.Type: GrantFiled: July 1, 2019Date of Patent: June 15, 2021Assignee: OLYMPUS CORPORATIONInventors: Naohiro Ariga, Shintaro Takahashi, Yohei Tanikawa, Shinichi Takimoto
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Publication number: 20200175254Abstract: An observation system includes a processor. The processor manages a plurality of images acquired in time series with respect to a biological sample which is being cultured, records a first comment and a first region of interest (RoI) in a storage device in association with the images based on user's instructions, and records a second comment and a second ROI in the storage device in association with the first comment based on user's instructions.Type: ApplicationFiled: February 10, 2020Publication date: June 4, 2020Applicant: OLYMPUS CORPORATIONInventors: Shinichi TAKIMOTO, Yohei TANIKAWA, Taiji MINE, Takayuki NAKATOMI, Masakazu FUJII
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Publication number: 20200124836Abstract: A cell observation system according to the present invention includes: a first image-acquisition device disposed in an incubator and acquires a first image of cells in a culturing vessel; a second image-acquisition device disposed outside the incubator; a processing device connected to the first image-acquisition device and the second image-acquisition device; and a display displays at least a region of the first image, as well as the second image. The second image-acquisition device includes a second image-acquisition unit that acquires a second image of the interior of the culturing vessel, that removed from the incubator. The processing device extracts target cells in the first image, calculates positions at which the extracted target cells are present and stores the positions in the memory, and causes the display to display the positions at which the target cells are present in a superimposed manner on an indication indicating the culturing vessel.Type: ApplicationFiled: December 22, 2019Publication date: April 23, 2020Applicant: OLYMPUS CORPORATIONInventors: Takashi MIYOSHI, Shinichi TAKIMOTO, Yasunobu IGA, Shintaro TAKAHASHI
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Publication number: 20200126225Abstract: A cell observation system according to the present invention includes: a first image-acquisition device disposed in an incubator and acquires a first image of cells in a culturing vessel; a second image-acquisition device disposed outside the incubator; a processing device connected to the first and second image-acquisition devices; and a display. The second image-acquisition device includes a second image-acquisition unit that acquires a second image of the interior of the culturing vessel that removed from the incubator, a support that supports the second image-acquisition unit and the culturing vessel, and a position measuring unit that measures a position between the culturing vessel and the second image-acquisition unit at the time of acquiring the second image. The processing device extracts target cells in the first image, calculates positions of the target cells, and displays the relationship between the positions of the target cells and the second image.Type: ApplicationFiled: December 22, 2019Publication date: April 23, 2020Applicant: OLYMPUS CORPORATIONInventors: Takashi MIYOSHI, Shinichi TAKIMOTO, Yasunobu IGA, Shintaro TAKAHASHI
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Patent number: 10621413Abstract: The number of cells existing and the positions thereof in a container that contains the cells can be grasped at a glance. Provided is an analysis-result browsing device that includes: a camera that captures cells at set capturing positions; a processing unit that detects and analyzes the cells captured by the camera, for the respective capturing positions; a display unit that displays analysis results of the cells analyzed by the processing unit, together with a container map that shows a container and the plurality of capturing positions in the container; and a control unit that sets the capturing positions in the container, which contains the cells, and simultaneously displays the analysis results of the cells at at least two of the capturing positions on the container map, which is displayed on the display unit.Type: GrantFiled: March 20, 2018Date of Patent: April 14, 2020Assignee: OLYMPUS CORPORATIONInventors: Mina Kobayashi, Ayumu Sakurai, Toshiyuki Hattori, Naohiro Ariga, Shinichi Takimoto, Taiji Mine
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Publication number: 20200110923Abstract: A quantitative evaluation apparatus of the present invention includes: a counter that counts the numbers of cells or densities of cells contained in individual images of a plurality of image-capturing regions in a culturing vessel for culturing the cells; an evaluation-value calculating portion that calculates an evaluation value related to variation in the distribution of the cells in the culturing vessel on the basis of the numbers of the cells or the densities of cells counted by means of the counter in each of the images; a determining portion that determines whether or not the evaluation value calculated by the evaluation-value calculating portion is in a range of a prescribed threshold; and a display that displays determination result determined by the determining portion.Type: ApplicationFiled: December 9, 2019Publication date: April 9, 2020Applicant: OLYMPUS CORPORATIONInventors: Yohei TANIKAWA, Shinichi TAKIMOTO, Shintaro TAKAHASHI, Masaru MIZUNAKA, Akira MATSUSHITA, Tsuyoshi MOCHIZUKI, Koh MOHRI
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Publication number: 20200073104Abstract: An image reproducing device includes one or more processors. The processor acquires image group data including a plurality of images and tag information on at least one tag. The images relate to a biological sample along time series. The tag information relates to an operation on the biological sample and is associated with at least part of the images. The processor selects from the plurality of images using the tag information, images to be reproduced along the time series as reproduction selected images. The processor outputs to a display, data relating to the images for the reproduction selected images to be reproduced along time series.Type: ApplicationFiled: November 8, 2019Publication date: March 5, 2020Applicant: OLYMPUS CORPORATIONInventors: Yohei TANIKAWA, Shinichi TAKIMOTO, Masakazu FUJII, Taiji MINE, Takayuki NAKATOMI
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Patent number: 10501718Abstract: Provided is an observation apparatus including: a housing that has, in a top face thereof, a transmission window on which a container accommodating cells can be placed and through which light can pass; a camera portion that is accommodated in the housing and that captures observation light coming from the cells irradiated with illumination light emitted from an illumination portion and entering the housing by passing through a bottom face of the container and the transmission window of the housing; and a housing-interior heating portion that is accommodated in the housing and that heats the cells.Type: GrantFiled: December 20, 2017Date of Patent: December 10, 2019Assignee: OLYMPUS CORPORATIONInventors: Akira Matsushita, Shintaro Takahashi, Masaru Mizunaka, Shinichi Takimoto, Tadashi Hirata, Yohei Tanikawa
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Publication number: 20190333215Abstract: A cell observation system includes an imaging element that acquires images of the inside of a culture container in which cells are cultured, the imaging element acquiring the images over time; a computer configured to: quantitatively analyze a culture state of the cells cultured in the culture container on the basis of each of the images acquired by the imaging element; and statistically analyze the quantitatively analyzed data; and a display that displays statistical analysis results in the culture container within a plurality of subculture periods obtained by the computer in a manner allowing comparison of the statistical analysis results.Type: ApplicationFiled: July 1, 2019Publication date: October 31, 2019Applicant: OLYMPUS CORPORATIONInventors: Naohiro ARIGA, Shintaro TAKAHASHI, Yohei TANIKAWA, Shinichi TAKIMOTO
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Patent number: 10438047Abstract: For the purpose of counting the number of cells within a culture container readily and accurately, a cell analysis device includes a cell-image acquiring unit that acquires an image of cells within a culture container in which the cells are cultured, a usability determining unit that determines whether or not the image acquired by the cell-image acquiring unit is usable, a number-of-cells counting unit that counts the number of cells within the image determined as being usable by the usability determining unit, and a number-of-cells calculating unit that calculates the number of cells within the culture container based on the number of cells counted by the number-of-cells counting unit.Type: GrantFiled: October 5, 2017Date of Patent: October 8, 2019Assignee: OLYMPUS CORPORATIONInventors: Yasunobu Iga, Shinichi Takimoto, Yohei Tanikawa, Yoshinobu Akahori
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Patent number: 10385300Abstract: A cell analysis apparatus including: a cell image acquisition unit that acquires an image of cells in a culture vessel in which cells are cultured; a smoothing processing unit that smooths luminance values in the image acquired by the cell image acquisition unit; a minimum-value detecting unit that detects minimum values of the luminance values smoothed by the smoothing processing unit; a smallest-minimum-value extracting unit that extracts smallest minimum values which are the smallest in regions according to the sizes of the cells, from the minimum values detected by the minimum-value detecting unit; a counting unit that counts the number of smallest minimum values extracted by the smallest-minimum-value extracting unit; and a cell-count calculating unit that calculates the number of cells in the culture vessel on the basis of the number of smallest minimum values counted by the counting unit.Type: GrantFiled: July 19, 2017Date of Patent: August 20, 2019Assignee: OLYMPUS CORPORATIONInventors: Yasunobu Iga, Yohei Tanikawa, Shinichi Takimoto, Yoshinobu Akahori
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Publication number: 20190219810Abstract: An observation apparatus including: a light-source that emits illumination light and excitation light upward from below a specimen; and an image-capturing optical system having an objective lens that focuses, below the specimen, transmitted light, which is the illumination light that is emitted from the light-source, that is reflected above the specimen, and that has passed through the specimen, and fluorescence that is generated in the specimen that has been irradiated with the excitation light emitted from the light-source, wherein the light-source is disposed radially outside the objective lens.Type: ApplicationFiled: March 26, 2019Publication date: July 18, 2019Applicant: OLYMPUS CORPORATIONInventors: Masaru MIZUNAKA, Shintaro TAKAHASHI, Akira MATSUSHITA, Yohei TANIKAWA, Tsuyoshi MOCHIZUKI, Shinichi TAKIMOTO
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Publication number: 20190218500Abstract: A culture observation system including: an observation device disposed in an incubator; a station server disposed outside the incubator and that transmitting and receiving information to and from the observation device; and a terminal for transmitting and receiving information to and from the station server. The observation device includes: a light source emitting illumination light from below a sample to thereabove, said sample being accommodated in a container formed of an optically transparent material; and an image acquisition unit for acquiring, below the sample, an image of transmitted light that has passed through the sample as a result of the illumination light emitted from the light source unit being reflected above the sample. The image acquisition unit includes an objective lens for collecting transmitted light that has passed through the sample, and the light source unit emits illumination light from radially outward of the objective lens to above the sample.Type: ApplicationFiled: March 21, 2019Publication date: July 18, 2019Applicant: OLYMPUS CORPORATIONInventors: Shinichi TAKIMOTO, Taiji MINE, Takayuki NAKATOMI
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Publication number: 20190219809Abstract: An observation apparatus including: a top plate on which a container in which a specimen is accommodated can be placed, and through which illumination light can pass; a light source that emits the illumination light upward from below the specimen; an objective lens that focuses, below the specimen and the top plate, transmitted light which is the illumination light that has passed through the specimen from thereabove and that has passed through the top plate; and a camera that captures the transmitted light, wherein the light source emits the illumination light toward an area above the specimen from outside the objective lens in a radial direction, and the top plate is provided with a mark that specifies a viewing-field area of the camera.Type: ApplicationFiled: March 27, 2019Publication date: July 18, 2019Applicant: OLYMPUS CORPORATIONInventors: Tsuyoshi MOCHIZUKI, Shintaro TAKAHASHI, Akira MATSUSHITA, Yohei TANIKAWA, Masaru MIZUNAKA, Shinichi TAKIMOTO