Patents by Inventor Shinichi Yaguchi
Shinichi Yaguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11925483Abstract: A risk estimation apparatus includes a data acquisition unit that acquires measured data of foot pressures of the left foot and the right foot obtained by sensors that are provided in shoes and measure the foot pressures, a stance phase identification unit that identifies a starting timing and an ending timing of a stance phase of each of the left foot and the right foot from the measured data of the foot pressures, and a risk estimation unit that estimates a risk of abnormality of a lower limb on the basis of asymmetry between the foot pressures of the left foot and the right foot during the stance phase.Type: GrantFiled: June 29, 2021Date of Patent: March 12, 2024Assignee: NEC CORPORATIONInventors: Chenhui Huang, Kenichiro Fukushi, Yusuke Sekiguchi, Haruki Yaguchi, Keita Honda, Shinichi Izumi, Dai Owaki
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Patent number: 9132130Abstract: Disclosed are: a novel purine derivative, a composition thereof, a method for treating tumor using the purine derivative, and an antitumor agent using the purine derivative. Specifically disclosed is a compound represented by formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof, or a prodrug thereof.Type: GrantFiled: April 28, 2010Date of Patent: September 15, 2015Assignee: ZENYAKU KOGYO KABUSHIKI KAISHAInventors: Toshiaki Suzuki, Hideki Satoh, Toshiyuki Matsuno, Kenichi Saitoh, Soichi Ohta, Manami Masuda, Shinichi Yaguchi, Ichiro Koshimizu, Yuriko Watanabe, Yoshie Minowa, Masayuki Takahashi, Tomoyoshi Kayou
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Patent number: 8338414Abstract: A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.Type: GrantFiled: May 24, 2010Date of Patent: December 25, 2012Assignee: Zenyaku Kogyo KabushikiKaishaInventors: Kazuhiko Haruta, Shinichi Yaguchi, Toshiyuki Matsuno, Yoshio Tsuchida, Tetsuo Watanabe, Kimitomo Yoshioka, Ryogo Yui
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Patent number: 8227463Abstract: [Problems] The object is to improve the absorbability of a heterocyclic compound including s-triazine and a pyrimidine derivative in vitro. [Means for Solving Problems] Disclosed is, for example, an amorphous body of a heterocyclic compound as represented by the general formula (I) [wherein each of R's and others is as defined in the description] including s-triazine and a pyrimidine derivative, or a hydrate, a solvate or a pharmaceutically acceptable salt of the heterocyclic compound. Also disclosed is a process for producing the amorphous body. Further disclosed are: a solid dispersion comprising the amorphous body; and a medicinal preparation comprising the solid dispersion.Type: GrantFiled: November 21, 2008Date of Patent: July 24, 2012Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Tadaaki Sugama, Nobuhiro Ishihara, Yoshiharu Tanaka, Masayuki Takahashi, Shinichi Yaguchi, Tetsuo Watanabe
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Publication number: 20120088765Abstract: Disclosed are: a novel purine derivative, a composition thereof, a method for treating tumor using the purine derivative, and an antitumor agent using the purine derivative. Specifically disclosed is a compound represented by formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof, or a prodrug thereof.Type: ApplicationFiled: April 28, 2010Publication date: April 12, 2012Applicant: Zenyaku Kogyo KabushikikaishaInventors: Toshiaki Suzuki, Hideki Satoh, Toshiyuki Matsuno, Kenichi Saitoh, Soichi Ohta, Manami Masuda, Shinichi Yaguchi, Ichiro Koshimizu, Yuriko Watanabe, Yoshie Minowa, Masayuki Takahashi, Tomoyoshi Kayou
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Patent number: 7855199Abstract: Heterocyclic compounds represented by the formula I and anti-malignant-tumor agents containing the heterocyclic compounds as effective components: wherein X represents nitrogen atom or CH; Y represents C1-C6 alkyl; R1 represents morpholino (which may be substituted with one to four C1-C6 alkyl); and R2 and R3 each represent hydrogen atom or C1-C6 alkyl.Type: GrantFiled: March 30, 2005Date of Patent: December 21, 2010Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Seiichiro Kawashima, Mitsuko Kawashima, legal representative, Hiroto Kawashima, legal representative, Masato Kawashima, legal representative, Toshiyuki Matsuno, Shinichi Yaguchi, Yoshio Tsuchida, Kenichi Saitoh, Tetsuo Watanabe
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Publication number: 20100267700Abstract: A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.Type: ApplicationFiled: May 24, 2010Publication date: October 21, 2010Applicant: ZENYAKU KOGYO KABUSHIKI KAISHAInventors: Kazuhiko Haruta, Shinichi Yaguchi, Toshiyuki Matsuno, Yoshio Tsuchida, Tetsuo Watanabe, Kimitomo Yoshioka, Ryogo Yui
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Publication number: 20100249063Abstract: [Problems] The object is to improve the absorbability of a heterocyclic compound including s-triazine and a pyrimidine derivative in vitro. [Means for Solving Problems] Disclosed is, for example, an amorphous body of a heterocyclic compound as represented by the general formula (I) [wherein each of R's and others is as defined in the description] including s-triazine and a pyrimidine derivative, or a hydrate, a solvate or a pharmaceutically acceptable salt of the heterocyclic compound. Also disclosed is a process for producing the amorphous body. Further disclosed are: a solid dispersion comprising the amorphous body; and a medicinal preparation comprising the solid dispersion.Type: ApplicationFiled: November 21, 2008Publication date: September 30, 2010Applicant: Zenyaku Kogyo Kabushiki KaishaInventors: Tadaaki Sugama, Nobuhiro Ishihara, Yoshiharu Tanaka, Masayuki Takahashi, Shinichi Yaguchi, Tetsuo Watanabe
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Patent number: 7750001Abstract: A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.Type: GrantFiled: August 30, 2007Date of Patent: July 6, 2010Assignee: Zenyaku Kogyo KabushikikaishaInventors: Kazuhiko Haruta, Shinichi Yaguchi, Toshiyuki Matsuno, Yoshio Tsuchida, Tetsuo Watanabe, Kimitomo Yoshioka, Ryogo Yui
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Publication number: 20080287431Abstract: Heterocyclic compounds represented by the formula I and anti-malignant-tumor agents containing the heterocyclic compounds as effective components: wherein X represents nitrogen atom or CH; Y represents C1-C6 alkyl; R1 represents morpholino (which may be substituted with one to four C1-C6 alkyl); and R2 and R3 each represent hydrogen atom or C1-C6 alkyl.Type: ApplicationFiled: March 30, 2005Publication date: November 20, 2008Applicant: ZENYAKU KOGYO KABUSHIKI KAISHAInventors: Seiichiro Kawashima, Mitsuko Kawashima, Hiroto Kawashima, Masato Kawashima, Toshiyuki Matsuno, Shinichi Yaguchi, Yoshio Tsuchida, Kenichi Saitoh, Tetsuo Watanabe
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Publication number: 20080113987Abstract: A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.Type: ApplicationFiled: August 30, 2007Publication date: May 15, 2008Applicant: ZENYAKU KOGYO KABUSHIKIKAISHAInventors: Kazuhiko Haruta, Shinichi Yaguchi, Toshiyuki Matsuno, Yoshio Tsuchida, Tetsuo Watanabe, Kimitomo Yoshioka, Ryogo Yui
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Patent number: 7307077Abstract: The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as effective components: wherein X represents nitrogen atom or CH; R1 represents CHnF3-n (wherein n is 1 or 2), hydroxy C1-C6 alkyl, NHR6 [wherein R6 represents hydrogen atom or COR (wherein R represents hydrogen atom, C1-C6 alkyl or C1-C6 alkoxy)]; R2 represents morpholino (which may be substituted with one to four C1-C6 alkyl), thiomorpholino, piperidino, pyrrolidinyl (which may be substituted with hydroxy C1-C6 alkyl), oxazolidinyl (which may be substituted with one or two C1-C6 alkyl) or tetrahydro-1,4-thiazin-1-oxo-4-yl; R3 and R4 each represent hydrogen atom or C1-C6 alkyl; and R5 represents hydrogen atom, amino or hydroxyl.Type: GrantFiled: July 3, 2006Date of Patent: December 11, 2007Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Seiichiro Kawashima, Toshiyuki Matsuno, Shinichi Yaguchi, Hiroya Sasahara, Tetsuo Watanabe
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Publication number: 20070244110Abstract: The present application describes a method of treating prostate cancer, melanoma or hepatic cancer in a subject in need thereof, the method comprising administering to said subject a therapeutically effective amount of the heterocyclic compound represented by Formula I or its pharmaceutically acceptable salt:Type: ApplicationFiled: April 14, 2006Publication date: October 18, 2007Applicant: ZENYAKU KOGYO KABUSHIKI KAISHAInventors: Shinichi Yaguchi, Ichiro Koshimizu, Hisashi Yoshimi, Toshiyuki Matsuno, Tetsuo Watanabe, Yoshio Tsuchida, Kenichi Saitoh
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Patent number: 7153853Abstract: The present invention relates to heterocyclic compounds represented by the formula I wherein X represents nitrogen atom or CH; R1 represents halogen atom or hydroxyl; R2 represents hydrogen atom, hydroxyl or amino; R3 represents morpholino (which may be substituted with one or two C1–C6 alkyl), pyrrolidinyl (which may be substituted with hydroxy C1–C6 alkyl) or NR6R7 [R6 represents C1–C6 alkyl and R7 represents piperidinyl (which may be substituted with C1–C6 alkyl)]; R4 and R5 each represents hydrogen atom or C1–C6 alkyl, with the proviso that R2 is hydrogen atom and R3 is pyrrolidinyl (which may be substituted with hydroxy C1–C6 alkyl) when R1 is hydroxylType: GrantFiled: October 24, 2003Date of Patent: December 26, 2006Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Seiichiro Kawashima, Toshiyuki Matsuno, Shinichi Yaguchi, Yoshio Tsuchida, Kenichi Saitoh, Hiroya Sasahara, Tetsuo Watanabe
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Publication number: 20060247232Abstract: The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as effective components: wherein X represents nitrogen atom or CH; R1 represents CHnF3-n (wherein n is 1 or 2), hydroxy C1-C6 alkyl, NHR6 [wherein R6 represents hydrogen atom or COR (wherein R represents hydrogen atom, C1-C6 alkyl or C1-C6 alkoxy)]; R2 represents morpholino (which may be substituted with one to four C1-C6 alkyl), thiomorpholino, piperidino, pyrrolidinyl (which may be substituted with hydroxy C1-C6 alkyl), oxazolidinyl (which may be substituted with one or two C1-C6 alkyl) or tetrahydro-1,4-thiazin-1-oxo-4-yl; R3 and R4 each represent hydrogen atom or C1-C6 alkyl; and R5 represents hydrogen atom, amino or hydroxyl.Type: ApplicationFiled: July 3, 2006Publication date: November 2, 2006Applicant: ZENYAKU KOGYO KABUSHIKI KAISHAInventors: Seiichiro Kawashima, Toshiyuki Matsuno, Shinichi Yaguchi, Hiroya Sasahara, Tetsuo Watanabe
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Patent number: 7071189Abstract: The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as effective components: wherein X represents nitrogen atom or CH; R1 represents CHnF3-n (wherein n is 1 or 2), hydroxy C1–C6 alkyl, NHR6 [wherein R6 represents hydrogen atom or COR (wherein R represents hydrogen atom, C1–C6 alkyl or C1–C6 alkoxy)]; R2 represents morpholino (which may be substituted with one to four C1–C6 alkyl), thiomorpholino, piperidino, pyrrolidinyl (which may be substituted with hydroxy C1–C6 alkyl), oxazolidinyl (which may be substituted with one or two C1–C6 alkyl) or tetrahydro-1,4-thiazin-1-oxo-4-yl; R3 and R4 each represent hydrogen atom or C1–C6 alkyl; and R5 represents hydrogen atom, amino or hydroxyl.Type: GrantFiled: April 26, 2002Date of Patent: July 4, 2006Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Seiichiro Kawashima, Toshiyuki Matsuno, Shinichi Yaguchi, Hiroya Sasahara, Tetsuo Watanabe
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Publication number: 20060009440Abstract: The present invention relates to heterocyclic compounds represented by the formula I wherein X represents nitrogen atom or CH; R1 represents halogen atom or hydroxyl; R2 represents hydrogen atom, hydroxyl or amino; R3 represents morpholino (which may be substituted with one or two C1-C6 alkyl), pyrrolidinyl (which may be substituted with hydroxy C1-C6 alkyl) or NR6R7 [R6 represents C1-C6 alkyl and R7 represents piperidinyl (which may be substituted with C1-C6 alkyl)]; R4 and R5 each represents hydrogen atom or C1-C6 alkyl, with the proviso that R2 is hydrogen atom and R3 is pyrrolidinyl (which may be substituted with hydroxy C1-C6 alkyl) when R1 is hydroxylType: ApplicationFiled: October 24, 2003Publication date: January 12, 2006Inventors: Seiichiro Kawashima, Toshiyuki Matsuno, Shinichi Yaguchi, Yoshio Tsuchida, Kenichi Saitoh, Hiroya Sasahara, Tetsuo Watanabe
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Publication number: 20040116421Abstract: The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as effective components: 1Type: ApplicationFiled: October 27, 2003Publication date: June 17, 2004Inventors: Seiichiro Kawashima, Toshiyuki Matsuno, Shinichi Yaguchi, Hiroya Sasahara, Tetsuo Watanabe
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Patent number: 6251900Abstract: Heterocyclic compounds in which s-triazine or pyrimidine is substituted with benzimidazole and morpholine and which are represented by the Formula I or phermaceutically acceptable acid addition salts thereof: wherein X and Y respectively represent nitrogen atom or one of them represents nitrogen atom and the other represents C—R7 wherein R7 represents hydrogen or halogen atom; R1, R2, R4, R5 and R6 represent hydrogen atom or C1-C6 alkyl; R3 represents morpholino, piperidino, piperazinyl, thiomorpholino, benzimidazolyl, cyano or the like.Type: GrantFiled: January 21, 2000Date of Patent: June 26, 2001Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Seiichiro Kawashima, Toshiyuki Matsuno, Shinichi Yaguchi, Tetsuo Watanabe, Masahiro Inaba
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Patent number: 5489591Abstract: s-Triazine (1,3,5-triazine) is chemically modified to obtain s-triazine derivative effective for prevention and treatment of estrogen-dependent diseases.Type: GrantFiled: August 29, 1994Date of Patent: February 6, 1996Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Hideshi Kobayashi, Toshihiko Komatsu, Seiichi Fukuda, Yoshio Tsuchida, Masanobu Kato, Shinichi Yaguchi, Naohito Ogose, Hajime Ono, Yasuhiro Izumisawa, Masayuki Takahashi, Tsutomu Nakagane