Abstract: The present invention relates to a nootropic agent which comprises a derivative of 2-phenyl-3-oxo-2H-1,4-benzothiazine. This nootropic agent is effective for treating diseases accompanied by a lowering of cerebral functions, for instance, cerebral infarction disorders due to ischemia such as transitory cerebral ischemia, brain edema, cerebral disorders due to the after-effect such as cerebral hemorrhage, cerebral disorders due to traumatic injury such as bruise, central nervous degeneration and degenerative diseases such as dementia, mental disorders, neurosis and Alzheimer's diseases.

Abstract: A preventing and treating agent for peripheral circulatory disturbances containing a compound represented by formula (I): ##STR1## wherein R represents an imidazolyl group, a thiazolyl group, or a pyridyl group; n represents 1 or 2; and m represents an integer of from 1 to 4, or a salt thereof as an active ingredient.

Abstract: An antidiabetic agent is disclosed, which comprises a compound represented by formula (I): ##STR1## wherein R represents an imidazolyl group, a thiazolyl group or a pyridyl group; n represents 1 or 2; and m represents an integer of from 1 to 4, or a pharmaceutically acceptable salt thereof as an active ingredient.

Abstract: A preventing and treating agent for heart failure is disclosed, which comprises a compound represented by formula (I): ##STR1## wherein R represents an imidazolyl group, a thiazolyl group or a pyridyl group; n represents 1 or 2; and m represents an integer of from 1 to 4, or a pharmaceutically acceptable salt thereof as an active ingredient.

Abstract: A method for treating and preventing retinopathy which comprises administering a therapeutically effective amount of 2-(2-phenyl-2-(2-pyridyl))ethyl-2-imidazoline or a pharmaceutically acceptable salt thereof to a patient having retinopathy is disclosed.

Abstract: 7-Piperidino-1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-2-one having platelet aggregation inhibitory activity is disclosed. The compound has high water-solubility and reduced influences on the circulatory system.

Abstract: The present invention provides derivatives of 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridin-2-one of the general formula: ##STR1## in which R is a hydrogen atom or a phenyl radical, which is optionally substituted by at least one halogen atom or lower alkyl radical, lower alkoxy radical, nitro group, carboxyl group, alkoxycarbonyl radical or cyano group, R' is a hydrogen atom or a lower alkyl radical and n is 0, 1, 2, 3, or 4; and the addition salts thereof with pharmaceutically acceptable mineral or organic acids.The present invention also provides a process for the preparation of these compounds, as well as pharmaceutical compositions containing them.

Abstract: The present invention provides a process for the preparation of 5,6,7,7a-tetrahydro-4H-pyridin-2-one derivatives of the general formula: ##STR1## in which R is a hydrogen atom or a phenyl radical optionally substituted by at least one halogen atom, lower alkyl radical, lower alkoxy radical, nitro group, carboxy group, alkoxycarbonyl radical or cyano group; R' is a hydrogen atom or a lower alkyl radical and n is 0, 1, 2, 3 or 4; and of their addition salts with mineral or organic acids, wherein a compound of the general formula: ##STR2## in which R, R' and n have the same meanings as above and R" is a hydrogen atom or an alkyl radical containing up to 4 carbon atoms, is treated in an organic solvent with gaseous hydrogen choloride and gaseous hydrogen sulphide. The compounds have platelet anti-aggregant and anti-thrombotic properties.

Abstract: A 1,2,3,5-tetrahydroimidazothienopyrimidin-2-one represented by the formula: ##STR1## wherein one of Z.sub.1, Z.sub.2 and Z.sub.3 is a sulfur atom and the remaining two of Z.sub.1, Z.sub.2 and Z.sub.3 represent CH, R.sub.1 and R.sub.2 each represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, a phenyl group, a chlorine atom or, when taken together R.sub.1 and R.sub.2 represent an alkylene chain of 3 to 5 carbon atoms, and R.sub.3 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and a pharmaceutically acceptable acid addition salt thereof, which exhibit an excellent blood platelet anti-aggregatory activity and are useful as anti-thrombotic agents.