Abstract: A compound represented by Formula [3] or a salt thereof and a method of making the in the formula, L3 represents a group represented by Formula [2c] wherein R3c, R4c, R5c and R6c are the same as or different from each other and represent a hydrogen atom or a C1-6 alkyl group; p3 represents an integer of 1 to 3; q3 represents an integer of 0 to 3; and r3 represents an integer of 1 to 6; A1 represents any one of the groups represented by Formulae [4] to [9], wherein * represents a binding position; and R7 represents a carboxyl-protecting group; and m represents an integer of 1 to 3.

Abstract: Provided is a welding program production system that can increase efficiency of a welding operation by a welding robot. The welding program production system includes a display control unit that causes a plurality of candidate welding lines detected on the basis of an image of a photographed object to be welded to be displayed in superimposed relation on the image, an input receiving unit that receives an input to select the welding lines from among the plurality of candidate welding lines and an input to specify a welding order and a welding direction for each of the selected welding lines, and a program production unit that produces a welding program on the basis of the specified welding order and welding direction.

Abstract: The work program production system includes a photographing unit that photographs an image including an object to be welded, a coordinate system setting unit that sets a user coordinate system based on a marker included in the image photographed by the photographing unit, a point-group-data plotting unit that detects a specific position of the marker on the basis of the image, sets the detected specific position on point group data acquired by a distance measurement sensor that measures a distance to the object to be welded, and plots, in the user coordinate system, the point group data to which coordinates in the user coordinate system using the set specific position as an origin are given, and a program production unit that produces a welding program so as to allow a welding robot virtually placed in the user coordinate system to perform a welding operation on the basis of the point group data plotted in the user coordinate system, while avoiding interference with the point group data.

Abstract: The welding line detection system includes a photographing unit that photographs an image of an object to be welded, a coordinate system setting unit that sets a user coordinate system based on a marker included in the photographed image, a point-group-data plotting unit that detects a specific position of the marker on the basis of the image, sets the detected specific position on point group data acquired by a distance measurement sensor that measures a distance to the object to be welded, and plots, in the user coordinate system, the point group data to which coordinates in the user coordinate system, using the set specific position as an origin, are given, and a welding line detection unit that detects, on the basis of the point group data plotted in the user coordinate system, a welding line of the object to be welded.

Abstract: An arc start adjustment device adjusting an arc start procedure in a welding process comprises an obtainment unit that obtains welding data indicating a welding state during or after a welding process, and a procedure adjustment unit that adjusts the arc start procedure such that the cycle time of the welding process is shortened based on welding data obtained by the obtainment unit.

Abstract: An arc start adjustment device adjusting an arc start procedure in a welding process comprises an obtainment unit that obtains welding data indicating a welding state during or after a welding process, and a procedure adjustment unit that adjusts the arc start procedure such that the cycle time of the welding process is shortened based on welding data obtained by the obtainment unit.

Abstract: The present invention provides a new approach for inhibiting myostatin signaling by targeting ACVR2B at the mRNA level.

Abstract: An arc start adjustment device adjusting an arc start procedure in a welding process comprises an obtainment unit that obtains welding data indicating a welding state during or after a welding process, and a procedure adjustment unit that adjusts the arc start procedure such that the cycle time of the welding process is shortened based on welding data obtained by the obtainment unit.

Abstract: According to an embodiment, a method for designing a mask set is provided. In the method for designing the mask set, an imprint-alignment mark is arranged in a region other than a chip region in an imprint shot formed in a template. The imprint-alignment mark is used for alignment during an imprint. Subsequently, the shape of the imprint shot is set based on an arrangement position of the imprint-alignment mark. Subsequently, another pattern is arranged in a region where the region is other than the chip region in the imprint shot and the imprint-alignment mark is not arranged. The other pattern is used in a process other than the imprint.

Abstract: There has been a demand for a novel antisense nucleic acid or the like capable of inhibiting myostatin at the mRNA level. The present invention provides a specific antisense oligomer which allows exon 2 skipping in the myostatin gene or induces degradation of mRNA of the myostatin gene.

Abstract: There has been a demand for a novel antisense nucleic acid or the like capable of inhibiting myostatin at the mRNA level. The present invention provides a specific antisense oligomer which allows exon 2 skipping in the myostatin gene or induces degradation of mRNA of the myostatin gene.

Abstract: An arc start adjustment device adjusting an arc start procedure in a welding process comprises an obtainment unit that obtains welding data indicating a welding state during or after a welding process, and a procedure adjustment unit that adjusts the arc start procedure such that the cycle time of the welding process is shortened based on welding data obtained by the obtainment unit.

Abstract: According to an embodiment, a method for designing a mask set is provided. In the method for designing the mask set, an imprint-alignment mark is arranged in a region other than a chip region in an imprint shot formed in a template. The imprint-alignment mark is used for alignment during an imprint. Subsequently, the shape of the imprint shot is set based on an arrangement position of the imprint-alignment mark. Subsequently, another pattern is arranged in a region where the region is other than the chip region in the imprint shot and the imprint-alignment mark is not arranged. The other pattern is used in a process other than the imprint.

Abstract: According to an embodiment, a method for designing a mask set is provided. In the method for designing the mask set, an imprint-alignment mark is arranged in a region other than a chip region in an imprint shot formed in a template. The imprint-alignment mark is used for alignment during an imprint. Subsequently, the shape of the imprint shot is set based on an arrangement position of the imprint-alignment mark. Subsequently, another pattern is arranged in a region where the region is other than the chip region in the imprint shot and the imprint-alignment mark is not arranged. The other pattern is used in a process other than the imprint.

Abstract: There has been a demand for a novel antisense nucleic acid or the like capable of inhibiting myostatin at the mRNA level. The present invention provides a specific antisense oligomer which allows exon 2 skipping in the myostatin gene or induces degradation of mRNA of the myostatin gene.

Abstract: According to one embodiment, an imprint template used for imprint includes a pattern region, a peripheral region, a region, and a first transmittance control part. The pattern region is provided with a first protrusion. The peripheral region surrounds the pattern region. The region is provided in the peripheral region and provided with a second protrusion. The first transmittance control part is provided in the peripheral region and configured to control intensity of light transmitted through the template in thickness direction. The template has a planar shape axisymmetric with respect to a line passing through center of the template. The region provided with the second protrusion and the first transmittance control part are provided at positions axisymmetric to each other with respect to the line passing through the center of the template.

Abstract: According to an embodiment, a method for designing a mask set is provided. In the method for designing the mask set, an imprint-alignment mark is arranged in a region other than a chip region in an imprint shot formed in a template. The imprint-alignment mark is used for alignment during an imprint. Subsequently, the shape of the imprint shot is set based on an arrangement position of the imprint-alignment mark. Subsequently, another pattern is arranged in a region where the region is other than the chip region in the imprint shot and the imprint-alignment mark is not arranged. The other pattern is used in a process other than the imprint.

Abstract: A control method for AC pulse arc welding performed upon application of cyclic AC welding current is provided. The welding current has a cycle including an electrode negative polarity period and an electrode positive polarity period subsequent to the electrode negative polarity period. In the control method, an electrode negative polarity base current and a subsequent electrode negative polarity peak current are applied during the electrode negative polarity period. The electrode negative polarity base current has an absolute value smaller than a first critical value, and the electrode negative polarity peak current has an absolute value greater than the first critical value. Then, an electrode positive polarity peak current is applied during the electrode positive polarity period. The electrode positive polarity peak current has a value greater than a second critical value.

Abstract: A control method for AC pulse arc welding performed upon application of cyclic AC welding current is provided. The welding current has a cycle including an electrode negative polarity period and an electrode positive polarity period subsequent to the electrode negative polarity period. In the control method, an electrode negative polarity base current and a subsequent electrode negative polarity peak current are applied during the electrode negative polarity period. The electrode negative polarity base current has an absolute value smaller than a first critical value, and the electrode negative polarity peak current has an absolute value greater than the first critical value. Then, an electrode positive polarity peak current is applied during the electrode positive polarity period. The electrode positive polarity peak current has a value greater than a second critical value.

Abstract: The present invention relates to oligo double-stranded RNAs for use in knockdown of the expression of Bcl-2 protein known as a suppressor for apoptosis, and pharmaceutical compositions containing them. It is known that Bcl-2 protein is over-expressed in diseases such as cancer, and by this over-expression, the growth of cancer cells is continued and the drug resistance to anti-cancer agents is caused. The present invention provides highly active oligo double-stranded RNAs cleaving bcl-2 mRNA and further provides pharmaceutical compositions comprising a complex of the oligo double-stranded RNA and a suitable carrier for inhibiting the expression of Bcl-2 protein.