Abstract: An information processing device comprises processing circuitry to: acquire pieces of train line information and departure and arrival times at each stop position of a train; split the train line information based on replacement stop positions at which a task for working on the train can switch between staffs, to obtain a plurality of pieces of task fragment information each indicating a task of a staff corresponding to each split train line part; and allocate the pieces of task fragment information to target durations to create work schedules indicating a schedule of tasks for each of the target durations, wherein a series of the tasks continuously allocated in each work schedule corresponds to a basic work schedule, each work schedule includes one or more basic work schedule and the processing circuitry performs allocation of the pieces of task fragment information based on a constraint related to the basic work schedule.

Abstract: An information processing device comprising processing circuitry to acquire information on operations each including an operation duration, a number of vehicles necessary for execution of each operation, and train information including a number of vehicles included in each train, mergeable or splittable among two or more trains; and produce an operation plan by allocating one or more trains to each operation, a total number of vehicles included in the allocated trains to each operation matches the number of vehicles necessary for the operation. Merge work of two or more trains is needed to allocate the two or more trains to one of the operations, and split work of the merged two or more trains is needed to allocate the two or more trains to different ones of the operations. The processing circuitry produces the operation plan based on a merge iteration number or a split iteration number.

Abstract: An information processing comprising a processing circuitry which acquire, with respect to a first route including first stop positions in which one of the first stop positions is a first transfer position, first train line information including a stop time and a departure time at the first stop positions of a first moving vehicle, acquire route information of a second route that includes second stop positions, one of the second stop positions being a second transfer position that allows a transfer to or from the first transfer position, and acquire number-of-passengers information on a number of passengers transferring from the first transfer position to the second transfer position or vice versa; and create second train line information including a stop time and a departure time at the second stop positions of a second moving vehicle, based on the first train line information, the route information and the number-of-passengers information.

Abstract: Methods for producing hepatocyte and/or cholangiocyte lineage cells from pluripotent stem cells, the method comprising (a) specifying the extended nodal agonist treated induced endodermal cell population to obtain a cell population comprising hepatocyte and/or cholangiocyte progenitors by contacting the extended nodal agonist treated induced endodermal cell population with specification media comprising a FGF agonist and a BMP4 agonist and/or active conjugates and/or fragments thereof; (b) inducing maturation, and optionally further lineage specification and/or expansion of the hepatocyte and/or cholangiocyte progenitors of the cell population to obtain a population comprising hepatocyte lineage cells such as hepatoblasts, hepatocytes and/or cholangiocytes, the inducing maturation step comprising generating aggregates of the cell population. Optionally, the method also comprises activating the cAMP pathway within the aggregates and forming co-aggregates.

Abstract: Provided herein are methods of making and using a number of different types of liver cells.

Abstract: Methods for producing hepatocyte and/or cholangiocyte lineage cells from pluripotent stem cells, the method comprising (a) specifying the extended nodal agonist treated induced endodermal cell population to obtain a cell population comprising hepatocyte and/or cholangiocyte progenitors by contacting the extended nodal agonist treated induced endodermal cell population with specification media comprising a FGF agonist and a BMP4 agonist and/or active conjugates and/or fragments thereof; (b) inducing maturation, and optionally further lineage specification and/or expansion of the hepatocyte and/or cholangiocyte progenitors of the cell population to obtain a population comprising hepatocyte lineage cells such as hepatoblasts, hepatocytes and/or cholangiocytes, the inducing maturation step comprising generating aggregates of the cell population. Optionally, the method also comprises activating the cAMP pathway within the aggregates and forming co-aggregates.

Abstract: Methods for producing hepatocyte and/or cholangiocyte lineage cells from pluripotent stem cells, the method comprising (a) specifying the extended nodal agonist treated induced endodermal cell population to obtain a cell population comprising hepatocyte and/or cholangiocyte progenitors by contacting the extended nodal agonist treated induced endodermal cell population with specification media comprising a FGF agonist and a BMP4 agonist and/or active conjugates and/or fragments thereof; (b) inducing maturation, and optionally further lineage specification and/or expansion of the hepatocyte and/or cholangiocyte progenitors of the cell population to obtain a population comprising hepatocyte lineage cells such as hepatoblasts, hepatocytes and/or cholangiocytes, the inducing maturation step comprising generating aggregates of the cell population. Optionally, the method also comprises activating the cAMP pathway within the aggregates and forming co-aggregates.

Abstract: The present invention relates to a novel triketone derivative having a specific structure and a herbicide containing the triketone derivative as an active ingredient. The herbicide is effective for controlling weeds which inhibit growth of crop plants, inter alia, for paddy weeds such as Sanwa millet and Scirups juncoides.

Abstract: The present invention relates to a novel triketone derivative having a specific structure and a herbicide containing the triketone derivative as an active ingredient. The herbicide is effective for controlling weeds which inhibit growth of crop plants, inter alia, for paddy weeds such as Sanwa millet and Scirups juncoides.