Patents by Inventor Shinichiro Oguni
Shinichiro Oguni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11971342Abstract: The sample preparation apparatus includes a measurement unit configured to measure a sample containing particles acquired from a sample container and detect measurement target particles in the sample, a sample preparation unit capable of adjusting the concentration of measurement target particles in a sample acquired from a sample container and configured to prepare a measurement sample by mixing a sample and any of a plurality of types of particle detection reagents including a particle labeling substance, and a control unit for controlling the sample preparation unit so as to generate concentration information of the measurement target particles in the sample in the sample container based on the measurement data of the measurement unit and adjust the concentration of the measurement target particles in the sample acquired from the sample container according to the generated concentration information and the type of particle detection reagent used for preparing the measurement sample.Type: GrantFiled: December 6, 2021Date of Patent: April 30, 2024Assignee: SYSMEX CORPORATIONInventors: Takaaki Nagai, Shinichiro Oguni, Tomohiro Tsuji
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Publication number: 20220091016Abstract: The sample preparation apparatus includes a measurement unit configured to measure a sample containing particles acquired from a sample container and detect measurement target particles in the sample, a sample preparation unit capable of adjusting the concentration of measurement target particles in a sample acquired from a sample container and configured to prepare a measurement sample by mixing a sample and any of a plurality of types of particle detection reagents including a particle labeling substance, and a control unit for controlling the sample preparation unit so as to generate concentration information of the measurement target particles in the sample in the sample container based on the measurement data of the measurement unit and adjust the concentration of the measurement target particles in the sample acquired from the sample container according to the generated concentration information and the type of particle detection reagent used for preparing the measurement sample.Type: ApplicationFiled: December 6, 2021Publication date: March 24, 2022Applicant: SYSMEX CORPORATIONInventors: Takaaki NAGAI, Shinichiro Oguni, Tomohiro Tsuji
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Patent number: 11226279Abstract: The sample preparation apparatus includes a measurement unit configured to measure a sample containing particles and detect measurement target particles in the sample, a sample preparation unit capable of adjusting the concentration of measurement target particles in a sample and configured to prepare a measurement sample by mixing a sample and a plurality of types of particle detection reagents, and a control unit configured to generate concentration information of the measurement target particles in the sample based on the measurement data of the measurement unit and adjust the concentration of the measurement target particles in the sample according to the generated concentration information and the type of particle detection reagent.Type: GrantFiled: May 30, 2018Date of Patent: January 18, 2022Assignee: SYSMEX CORPORATIONInventors: Takaaki Nagai, Shinichiro Oguni, Tomohiro Tsuji
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Publication number: 20200326332Abstract: The present invention provides a method for classifying and counting leukocytes which allows classification and count of normal leukocytes as well as discrimination between blast cells and atypical lymphocytes. The present invention also provides a regent kit and reagent for classifying leukocyte which are used for classifying and counting leukocytes in biological samples.Type: ApplicationFiled: June 29, 2020Publication date: October 15, 2020Applicant: SYSMEX CORPORATIONInventors: Saori Otsuka, Kazuki Hatcho, Toshihiro Mizukami, Shinichiro Oguni
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Publication number: 20180348112Abstract: The sample preparation apparatus 1 includes a measurement unit 2 configured to measure a sample containing particles acquired from a sample container 10 and detect measurement target particles in the sample, a sample preparation unit 3 capable of adjusting the concentration of measurement target particles in a sample acquired from a sample container 10 and configured to prepare a measurement sample by mixing a sample and any of a plurality of types of particle detection reagents including a particle labeling substance, and a control unit 4 for controlling the sample preparation unit 3 so as to generate concentration information of the measurement target particles in the sample in the sample container 10 based on the measurement data of the measurement unit 2 and adjust the concentration of the measurement target particles in the sample acquired from the sample container 10 according to the generated concentration information and the type of particle detection reagent used for preparing the measurement sample.Type: ApplicationFiled: May 30, 2018Publication date: December 6, 2018Inventors: Takaaki NAGAI, Shinichiro OGUNI, Tomohiro TSUJI
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Patent number: 9453790Abstract: A blood analyzer comprising: a specimen preparation section for preparing a measurement specimen that is used to measure a white blood cell count among CBC measurement items; a measurement section for obtaining optical information from blood cells contained in the measurement specimen; and a controller carrying out operations comprising: classifying blood cells contained in the measurement specimen into at least white blood cells and blood cells suspected to be abnormal blood cells based on the optical information; obtaining distribution data of the white blood cells and distribution data of the blood cells suspected to be abnormal blood cells; counting the white blood cells based on the distribution data of the white blood cells; and determining presence or absence of the abnormal blood cells in the blood sample, based on the distribution data of the blood cells suspected to be abnormal blood cells. A blood analyzing method and a computer program product are also disclosed.Type: GrantFiled: March 23, 2010Date of Patent: September 27, 2016Assignee: SYSMEX CORPORATIONInventors: Ayumu Yoshida, Shinichiro Oguni, Tatsuya Narikawa, Saori Suzuki
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Patent number: 9222934Abstract: The present invention provides a reagent for analysis of immature leukocytes comprising: a surfactant which can damage cell membranes of erythrocytes and mature leukocytes, a solubilizing agent which can shrink the damaged blood cells and at least one dye for staining nucleic acid selected from the dyes of the formulae (I) and (II), wherein X? is an anion.Type: GrantFiled: August 1, 2013Date of Patent: December 29, 2015Assignee: SYSMEX CORPORATIONInventors: Yukiko Kataoka, Tomohiro Tsuji, Shinichiro Oguni, Ayumu Yoshida, Masaki Abe
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Patent number: 8859200Abstract: The present invention provides a reagent for analysis of immature leukocytes comprising: a surfactant which can damage cell membranes of erythrocytes and mature leukocytes, a solubilizing agent which can shrink the damaged blood cells and at least one dye for staining nucleic acid selected from the dyes of the formulae (I) and (II), wherein X? is an anion.Type: GrantFiled: June 25, 2008Date of Patent: October 14, 2014Assignee: Sysmex CorporationInventors: Yukiko Kataoka, Tomohiro Tsuji, Shinichiro Oguni, Ayumu Yoshida, Masaki Abe
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Patent number: 8802025Abstract: The present invention provides a reagent kit for analyzing a sample comprising a first reagent containing a cationic surfactant, a nonionic surfactant and an aromatic carboxylic acid and a second reagent containing a fluorescent dye capable of staining nucleic acid, and a method for analyzing a sample using the kit.Type: GrantFiled: September 26, 2008Date of Patent: August 12, 2014Assignee: Sysmex CorporationInventors: Tatsuya Narikawa, Tomohiro Tsuji, Keiko Moriyama, Yuji Itose, Shinichiro Oguni, Ayumu Yoshida, Saori Suzuki, Toshihiro Mizukami
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Publication number: 20140120530Abstract: The present invention provides a method for classifying and counting leukocytes which allows classification and count of normal leukocytes as well as discrimination between blast cells and atypical lymphocytes. The present invention also provides a regent kit and reagent for classifying leukocyte which are used for classifying and counting leukocytes in biological samples.Type: ApplicationFiled: October 23, 2013Publication date: May 1, 2014Applicant: SYSMEX CORPORATIONInventors: Saori OTSUKA, Kazuki HATCHO, Toshihiro MIZUKAMI, Shinichiro OGUNI
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Publication number: 20140038179Abstract: The present invention provides a reagent for analysis of immature leukocytes comprising: a surfactant which can damage cell membranes of erythrocytes and mature leukocytes, a solubilizing agent which can shrink the damaged blood cells and at least one dye for staining nucleic acid selected from the dyes of the formulae (I) and (II), wherein X? is an anion.Type: ApplicationFiled: August 1, 2013Publication date: February 6, 2014Applicant: SYSMEX CORPORATIONInventors: Yukiko Kataoka, Tomohiro Tsuji, Shinichiro Oguni, Ayumu Yoshida, Masaki Abe
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Patent number: 8455209Abstract: The present invention provides a reagent for analysis of immature leukocytes comprising: a surfactant which can damage cell membranes of erythrocytes and mature leukocytes, a solubilizing agent which can shrink the damaged blood cells and a dye for staining nucleic acid, wherein the reagent has an osmotic pressure of not lower than 10 mOsm/kg and lower than 150 mOsm/kg.Type: GrantFiled: June 25, 2008Date of Patent: June 4, 2013Assignee: Sysmex CorporationInventors: Yukiko Kataoka, Tomohiro Tsuji, Shinichiro Oguni, Ayumu Yoshida, Masaki Abe
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Patent number: 7892850Abstract: An apparatus for measuring immature platelets is described that includes (a) a sample preparation unit for preparing an assay sample by adding a reagent to a blood specimen; (b) a detection unit having a semiconductor laser light source for irradiating the assay sample with laser light, and a detector for detecting optical information emitted from particles within the assay sample irradiated by laser light; and (c) a controller for differentiating and counting immature platelets based on the detected optical information. A method for measuring immature platelets is also described.Type: GrantFiled: July 1, 2004Date of Patent: February 22, 2011Assignee: Sysmex CorporationInventors: Shinichiro Oguni, Seido Biwa
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Patent number: 7892841Abstract: A measuring method and a measuring apparatus which can classify and count myeloblast more precisely without influence of other component in a sample including platelet aggregation in measurement of a blood sample with a flowcytometry, wherein damage is given to a cell membrane of erythrocyte and mature leukocyte contained in a hematological sample, a hemocyte in which a cell membrane is damaged is constricted, and this is dyeing-treated with a fluorescent dye which can stain a nucleic acid to obtain a sample, the sample is measured with a flowcytometer, and a cell contained in a first cell group containing myeloblast, which is specified based on forward scattered light information and side scattered light information, and contained in a second cell group containing myeloblast, which is specified based on forward scattered light information and fluorescent information, is counted as myeloblast.Type: GrantFiled: March 28, 2007Date of Patent: February 22, 2011Assignee: Sysmex CorporationInventors: Tomohiro Tsuji, Ayumu Yoshida, Shinichiro Oguni
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Publication number: 20100330565Abstract: The present invention provides a reagent kit for analyzing a sample comprising a first reagent containing a cationic surfactant, a nonionic surfactant and an aromatic carboxylic acid and a second reagent containing a fluorescent dye capable of staining nucleic acid, and a method for analyzing a sample using the kit.Type: ApplicationFiled: September 26, 2008Publication date: December 30, 2010Applicant: Sysmex CorporationInventors: Tatsuya Narikawa, Tomohiro Tsuji, Keiko Moriyama, Yuji Itose, Shinichiro Oguni, Ayumu Yoshida, Saori Suzuki, Toshihiro Mizukami
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Publication number: 20100248300Abstract: A blood analyzer comprising: a specimen preparation section for preparing a measurement specimen that is used to measure a white blood cell count among CBC measurement items; a measurement section for obtaining optical information from blood cells contained in the measurement specimen; and a controller carrying out operations comprising: classifying blood cells contained in the measurement specimen into at least white blood cells and blood cells suspected to be abnormal blood cells based on the optical information; obtaining distribution data of the white blood cells and distribution data of the blood cells suspected to be abnormal blood cells; counting the white blood cells based on the distribution data of the white blood cells; and determining presence or absence of the abnormal blood cells in the blood sample, based on the distribution data of the blood cells suspected to be abnormal blood cells. A blood analyzing method and a computer program product are also disclosed.Type: ApplicationFiled: March 23, 2010Publication date: September 30, 2010Inventors: Ayumu Yoshida, Shinichiro Oguni, Tatsuya Narikawa, Saori Suzuki
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Publication number: 20100184061Abstract: The present invention provides a reagent for analysis of immature leukocytes comprising: a surfactant which can damage cell membranes of erythrocytes and mature leukocytes, a solubilizing agent which can shrink the damaged blood cells and a dye for staining nucleic acid, wherein the reagent has an osmotic pressure of not lower than 10 mOsm/kg and lower than 150 mOsm/kg.Type: ApplicationFiled: June 25, 2008Publication date: July 22, 2010Applicant: SYSMEX CORORATIONInventors: Yukiko Kataoka, Tomohiro Tsuji, Shinichiro Oguni, Ayumu Yoshida, Masaki Abe
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Publication number: 20100178654Abstract: The present invention provides a reagent for analysis of immature leukocytes comprising: a surfactant which can damage cell membranes of erythrocytes and mature leukocytes, a solubilizing agent which can shrink the damaged blood cells and at least one dye for staining nucleic acid selected from the dyes of the formulae (I) and (II), wherein X? is an anion.Type: ApplicationFiled: June 25, 2008Publication date: July 15, 2010Applicant: Sysmex CorporationInventors: Yukiko Kataoka, Tomohiro Tsuji, Shinichiro Oguni, Ayumu Yoshida, Masaki Abe
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Patent number: 7633604Abstract: A sample analyzer including a detection unit for irradiating a biological sample with light and obtaining optical information; a cell classification processor for classifying cells contained in the biological sample into cell groups based on the optical information; a scattered light information obtaining processor for obtaining scattered light information relating to a cell included in a predetermined cell group; a calculation processor for calculating a component value corresponding to an amount of component contained in cell included in the predetermined cell group based on the scattered light information; and an output device for outputting the component value calculated by the calculation means is disclosed. A computer program product is also disclosed.Type: GrantFiled: September 4, 2008Date of Patent: December 15, 2009Assignee: Sysmex CorporationInventors: Yoshiro Ikeuchi, Shinichiro Oguni, Daigo Fukuma, Masanori Imazu, Jo Lissen
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Patent number: 7625757Abstract: A reagent for analyzing immature leukocyte capable of analyzing accurately immature leukocyte such as myeloblast and immature granulocyte, and mature leukocyte, which reagent has broader allowable range of sample processing conditions than conventional ones, and a reagent kit are provided. The present invention relates to a reagent for analyzing immature leukocyte containing a surfactant for giving damage to cell membrane of red blood cell and mature leukocyte in the sample, a solubilizing agent for causing contraction to damaged blood cell, sugar, a dye for staining nucleic acid.Type: GrantFiled: January 9, 2007Date of Patent: December 1, 2009Assignee: Sysmex CorporationInventors: Tomohiro Tsuji, Ayumu Yoshida, Shinichiro Oguni