Patents by Inventor Shinichiro OHNO

Shinichiro OHNO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Artificial match-type miRNA for controlling gene expression and use therefor
    Patent number: 10934542
    Abstract: The invention provides an artificial match-type miRNA utilizing miRNA. In particular, the invention provides a single strand nucleic acid containing an X region and a Y region, wherein the 3?-terminal of the X region and the 5?-terminal of the Y region are linked via a linker region of a non-nucleotide structure, the X region contains a guide strand sequence of a mature miRNA, and the Y region contains a sequence completely complementary to the X region is an artificial match-type miRNA. The artificial match-type miRNA can suppress expression of the target gene.
    Type: Grant
    Filed: December 27, 2014
    Date of Patent: March 2, 2021
    Assignees: BONAC CORPORATION, TOKYO MEDICAL UNIVERSITY
    Inventors: Masahiko Kuroda, Shinichiro Ohno, Eriko Aoki, Yasuhiko Yoshida, Shiori Kato, Tadaaki Ohgi
  • Artificial mimic miRNA for controlling gene expression, and use of same
    Patent number: 10612020
    Abstract: The present disclosure is directed to an artificial mimic miRNA utilizing miRNA. An artificial mimic miRNA is a single-stranded nucleic acid including: a X region; and a Y region, the Y region and the X region being linked, wherein the X region is a guide strand sequence of a mature miRNA or a partial sequence of the guide strand sequence of the mature miRNA and consists of a linking side region (XB) and a non-linking side region (XF) to the Y region, the linking side region (XB) is a sequence that does not cause intramolecular annealing within its region, and the Y region is a sequence that intramolecularly anneals to the non-linking side region (XF) of the X region. According to the artificial mimic miRNA of the present invention, the expression of the target gene can be inhibited.
    Type: Grant
    Filed: December 26, 2014
    Date of Patent: April 7, 2020
    Assignee: Tokyo Medical University
    Inventors: Masahiko Kuroda, Shinichiro Ohno
  • THERAPEUTIC AGENT FOR EYE DISEASE
    Publication number: 20180099004
    Abstract: The present invention provides a single stranded nucleic acid molecule represented by the following formula (I): (I) (SEQ?ID?NO:?1) 5?-uagcaccauuugaaaucaguguucc-P- ggaacacugauuucaaauggugcuauu-3? wherein —P— shows a proline derivative linker represented by the following formula (Ia): an agent for treating corneal diseases such as ocular surface disorders and the like, comprising the single stranded nucleic acid molecule as an active ingredient.
    Type: Application
    Filed: April 15, 2016
    Publication date: April 12, 2018
    Applicants: THE UNIVERSITY OF TOKYO, TOKYO MEDICAL UNIVERSITY, BONAC CORPORATION
    Inventors: Hirofumi TAKEUCHI, Tomohiko USUI, Masahiko KURODA, Masakatsu TAKANASHI, Shinichiro OHNO, Hidekazu TOYOFUKU, Kohei TAHARA, Risako ONODERA
  • ARTIFICIAL MIMIC MIRNA FOR CONTROLLING GENE EXPRESSION, AND USE OF SAME
    Publication number: 20170037398
    Abstract: The present invention provides a novel artificial mimic miRNA utilizing miRNA. An artificial mimic miRNA is a single-stranded nucleic acid including: a X region; and a Y region, the Y region and the X region being linked, wherein the X region is a guide strand sequence of a mature miRNA or a partial sequence of the guide strand sequence of the mature miRNA and consists of a linking side region (XB) and a non-linking side region (XF) to the Y region, the linking side region (XB) is a sequence that does not cause intramolecular annealing within its region, and the Y region is a sequence that intramolecularly anneals to the non-linking side region (XF) of the X region. According to the artificial mimic miRNA of the present invention, the expression of the target gene can be inhibited.
    Type: Application
    Filed: December 26, 2014
    Publication date: February 9, 2017
    Inventors: Masahiko Kuroda, Shinichiro Ohno
  • ARTIFICIAL MATCH-TYPE miRNA FOR CONTROLLING GENE EXPRESSION AND USE THEREFOR
    Publication number: 20160319282
    Abstract: The invention provides an artificial match-type miRNA utilizing miRNA. A In particular, the invention provides a single strand nucleic acid containing an X region and a Y region, wherein the 3?-terminal of the X region and the 5?-terminal of the Y region are linked via a linker region of a non-nucleotide structure, the X region contains a guide strand sequence of a mature miRNA, and the Y region contains a sequence completely complementary to the X region is an artificial match-type miRNA. The artificial match-type miRNA can suppress expression of the target gene.
    Type: Application
    Filed: December 27, 2014
    Publication date: November 3, 2016
    Applicants: BONAC CORPORATION, TOKYO MEDICAL UNIVERSITY
    Inventors: Masahiko KURODA, Shinichiro OHNO, Eriko AOKI, Yasuhiko YOSHIDA, Shiori KATO, Tadaaki OHGI