Abstract: Provided is a technique for synthesizing a nicotinamide derivative (NAm derivative) such as a nicotinamide mononucleotide (NMN) with high efficiency. A genetically modified microorganism is used, which can express, as nicotinamide phosphoribosylt ransferase (NAMPT), NAMPT having a conversion efficiency of 5-folds or more that of human NAMPT.

Abstract: Even when a tin-based polymerization catalyst and a phosphorus-based compound are present in a poly-L-lactic acid (A) and a poly-D-lactic acid (B), by using a specific proportion of an organic acid metal salt or an organic metal salt for stereocomplex crystallization, a stereocomplex polylactic acid composition having a high stereocomplex crystallinity and a high stereocomplex crystal melting point, a small stereocomplex crystal melting point depression even after remelting, a small decrease in the molecular weight, excellent forming processability, and also heat resistance can be provided.

Abstract: A thermosetting resin composition which produces no free isocyanate even when a carbodiimide compound is used and provides a cured resin having high heat resistance. The thermosetting resin composition makes it possible to reduce the curing temperature, cures in a short time and provides a cured rein having a high glass transition temperature. The thermosetting resin composition includes: (A) an epoxy resin (component A); and (B) a cyclic carbodiimide compound (component B) including a cyclic structure having one carbodiimide group in which first nitrogen and second nitrogen are bonded together by a bond group and having 8 to 50 atoms forming the cyclic structure and/or (b) a polyvalent amine-based curing agent (component b).

Abstract: An object of the present invention is to provide a cyanate ester-based curable resin composition having a high curing rate, very high heat resistance and very high long-term heat resistance, and a molded article and a prepreg each using the same. The present invention relates to a thermosetting resin composition including (A) a cyanate ester compound and/or (B) an unsaturated imide compound, and (C) a cyclic carbodiimide compound. In addition, the present invention relates to a molded article including a cured product of the thermosetting resin composition, and a prepreg including a reinforcing fiber substrate impregnated with the thermosetting resin composition.

Abstract: Provided is a fiber containing a composition obtained by mixing a compound having at least a ring structure containing one carbodiimide group, the first nitrogen and second nitrogen thereof being linked together through a linking group, with a polymer compound having an acidic group. Also provided is a fiber structure made thereof. A fiber and a fiber structure, which have improved hydrolysis resistance and from which no free isocyanate compounds are produced, can be provided.

Abstract: An object of the present invention is to provide a technique for stably, inexpensively, and safely culturing stem cells having a differentiation ability while maintaining an undifferentiated state. The present invention relates to a medium for culturing stem cells, comprising at least one or more compounds selected from the group consisting of a ROCK inhibitor, a PKC inhibitor, a histone methyltransferase inhibitor, and a retinoic acid receptor agonist, and not containing a growth factor or having a low growth factor concentration; a method for culturing stem cells using the medium; a growth promoter for stem cell; as well as a cell composition containing stem cells or differentiated cells therefrom; and a method for producing the cell composition.

Abstract: A thermosetting resin composition which produces no free isocyanate even when a carbodiimide compound is used and provides a cured resin having high heat resistance. The thermosetting resin composition makes it possible to reduce the curing temperature, cures in a short time and provides a cured rein having a high glass transition temperature.

Abstract: An object of the present invention is to provide an albumin-free medium for serum-free culture of pluripotent stem cells capable of maintaining the undifferentiated state and the pluripotency (pluripotent ability) of the pluripotent stem cells, an additive for an albumin-free medium, and a culture method. The albumin-free medium for serum-free culture of pluripotent stem cells, the additive for an albumin-free medium, and a medium used for the culture method of the invention are characterized by containing at least one selected from the group consisting of a Pluronic nonionic surfactant, an animal-based hydrolysate, and a nonanimal-based hydrolysate.

Abstract: An object of the present invention is to provide a medium for culturing naive pluripotent stem cells which is for efficiently proliferating naive pluripotent stem cells while maintaining the undifferentiated state and the pluripotency (pluripotent capability) of the naive pluripotent stem cells.

Abstract: A resin composition including an aromatic polyester resin and having high levels of hydrolysis resistance and moldability is provided. The resin composition includes an aromatic polyester resin having a terminal carboxyl group content of not more than 30 eq/ton (component A), a cyclic carbodiimide compound having at least two carbodiimide rings, each having only one carbodiimide group (component B), and a polyvalent hydroxyl group-containing compound having a hydroxyl value of not less than 200 (component C).

Abstract: Provided are a resin composition controlled such that after keeping under a severe environment as in high temperature hot water or in hot water under chemically severe condition, such as an acidic or basic condition, etc., for a fixed period of time, it is quickly decomposed; and a structure thereof.

Abstract: A method of sealing an end of a polymer with a carbodiimide compound without liberating an isocyanate compound. A compound including a cyclic structure having one carbodiimide group whose first nitrogen and second nitrogen are bonded together by a bond group is used as an end-sealing agent for the polymer.

Abstract: A thermosetting resin composition which produces no free isocyanate even when a carbodiimide compound is used and provides a cured resin having high heat resistance. The thermosetting resin composition makes it possible to reduce the curing temperature, cures in a short time and provides a cured rein having a high glass transition temperature.

Abstract: Provided are a resin composition controlled such that after keeping under a severe environment as in high-temperature hot water or in hot water under chemically severe condition, such as an acidic or basic condition, etc., for a fixed period of time, it is quickly decomposed; and a structure thereof.

Abstract: A resin composition which comprises polylactic acid, does not release an isocyanate group at the time of production and has excellent hydrolysis resistance and a low environmental burden. The resin composition comprises: (A) 100 parts by weight of a resin component (component A) containing polylactic acid (component A-?); (B) 0.001 to 10 parts by weight of a compound (component B) having one carbodiimide group and a cyclic structure in which first nitrogen and second nitrogen are bonded to each other via a bonding group, the cyclic structure consisting of 8 to 50 atoms; and (C) 0.001 to 2 parts by weight of at least one antioxidant (component C) selected from the group consisting of a hindered phenol-based compound, a phosphite-based compound, a phosphonite-based compound and a thioether-based compound.

Abstract: Even when a tin-based polymerization catalyst and a phosphorus-based compound are present in a poly-L-lactic acid (A) and a poly-D-lactic acid (B), by using a specific proportion of an organic acid metal salt or an organic metal salt for stereocomplex crystallization, a stereocomplex polylactic acid composition having a high stereocomplex crystallinity and a high stereocomplex crystal melting point, a small stereocomplex crystal melting point depression even after remelting, a small decrease in the molecular weight, excellent forming processability, and also heat resistance can be provided.

Abstract: Provided are a resin composition controlled such that after keeping a shape thereof under a severe environment as in high-temperature hot water or in hot water under chemically severe condition, such as an acidic or basic condition, etc., for a fixed period of time, it is quickly decomposed; and a structure thereof.

Abstract: A process for the production of a carbodiimide, comprising the steps of: (1) reacting an amine represented by the following formula (A) with carbon disulfide in the presence of a catalyst at a reaction temperature of 50 to 150° C. to obtain a thiourea represented by the following formula (B): (In the above formula (A), R is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms.) (In the above formula (B), R is as defined in the above formula (A); (2) desulfurizing the obtained thiourea with a hypochlorite in the presence of a basic compound to obtain a carbodiimide represented by the following formula (C): (In the above formula (C), R is as defined in the above formula (A)); and (3) purifying the obtained carbodiimide.

Abstract: A process for producing an intermediate for a cyclic carbodiimide compound includes a process for producing an amine compound represented by the following formula (B), comprising the step of reducing a nitro compound represented by the following formula (A) and containing a compound having a haloarene skeleton in the presence of a metal catalyst and a basic compound. The process also includes a process for producing a thiourea compound, including the step of reacting an amine compound represented by the formula (B) with carbon disulfide in the presence of imidazole. (R is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms.) (R is as defined in the above formula (A).).

Abstract: Provided are a resin composition controlled such that after keeping under a severe environment as in high-temperature hot water or in hot water under chemically severe condition, such as an acidic or basic condition, etc., for a fixed period of time, it is quickly decomposed; and a structure thereof.