Patents by Inventor Shinji Aki
Shinji Aki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8598358Abstract: An object of the present invention is to provide a method for producing an oxazole compound in a high yield.Type: GrantFiled: January 28, 2011Date of Patent: December 3, 2013Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Akihiro Yamamoto, Koichi Shinhama, Nobuhisa Fujita, Shinji Aki, Shin Ogasawara, Naoto Utsumi
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Publication number: 20120302757Abstract: An object of the present invention is to provide a method for producing an oxazole compound in a high yield.Type: ApplicationFiled: January 28, 2011Publication date: November 29, 2012Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Akihiro Yamamoto, Koichi Shinhama, Nobuhisa Fujita, Shinji Aki, Shin Ogasawara, Naoto Utsumi
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Patent number: 8222276Abstract: The invention provides an amine salt of a carbostyril derivative formed from a carbostyril derivative represented by the formula (1) [wherein R is a halogen atom; the substituted position of the side chain is 3- or 4-position in the carbostyril skeleton; and the bonding between 3- and 4-positions of the carbostyril skeleton is a single bond or a double bond] and an amine; and the invention is useful as drugs for treating various diseases, especially as aqueous formulations due to the superior water solubility and the superior pharmacologic effects.Type: GrantFiled: April 26, 2010Date of Patent: July 17, 2012Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Yoshihiro Nishioka, Shinji Aki, Shigekazu Fujita, Yoshinao Onishi, Shun-ichiro Sumida
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Patent number: 7825251Abstract: The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high purity. The carbostyril derivatives (I) can be produced by reacting a carbostyril derivative (II) with a tetrazole derivative (III) in the presence of a phase transfer catalyst.Type: GrantFiled: August 3, 2007Date of Patent: November 2, 2010Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Shinji Aki, Muneaki Kurimura, Takao Nishi, Junichi Minamikawa, Michiaki Tominaga, Norihiro Fukuyama, Akihiro Yamamoto
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Publication number: 20100210684Abstract: The invention provides an amine salt of a carbostyril derivative formed from a carbostyril derivative represented by the formula (1) [wherein R is a halogen atom; the substituted position of the side chain is 3- or 4-position in the carbostyril skeleton; and the bonding between 3- and 4-positions of the carbostyril skeleton is a single bond or a double bond] and an amine; and the invention is useful as drugs for treating various diseases, especially as aqueous formulations due to the superior water solubility and the superior pharmacologic effects.Type: ApplicationFiled: April 26, 2010Publication date: August 19, 2010Inventors: Yoshihiro Nishioka, Shinji Aki, Shigekazu Fujita, Yoshinao Onishi, Shun-Ichiro Sumida
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Patent number: 7750156Abstract: The present invention provides an industrially advantageous method of producing aminophenol compounds represented by the formula (1) by a simple and easy procedure at a high yield and a high purity.Type: GrantFiled: March 25, 2005Date of Patent: July 6, 2010Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Hiroshi Kiyokawa, Shinji Aki
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Patent number: 7732611Abstract: The invention provides an amine salt of a carbostyril derivative formed from a carbostyril derivative represented by the formula (1) [wherein R is a halogen atom; the substituted position of the side chain is 3- or 4-position in the carbostyril skeleton; and the bonding between 3- and 4-positions of the carbostyril skeleton is a single bond or a double H bond] and an amine; and the invention is useful as drugs for treating various diseases, especially as aqueous formulations due to the superior water solubility and the superior pharmacologic effects.Type: GrantFiled: January 20, 2005Date of Patent: June 8, 2010Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Yoshihiro Nishioka, Shinji Aki, Shigekazu Fujita, Yoshinao Onishi, Shun-ichiro Sumida
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Patent number: 7399864Abstract: The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high purity. The carbostyril derivatives (I) can be produced by reacting a carbostyril derivative (II) with a tetrazole derivative (III) in the presence of a phase transfer catalyst.Type: GrantFiled: August 1, 2002Date of Patent: July 15, 2008Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Shinji Aki, Muneaki Kurimura, Takao Nishi, Junichi Minamikawa, Michiaki Tominaga
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Publication number: 20070282108Abstract: The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high purity. The carbostyril derivatives (I) can be produced by reacting a carbostyril derivative (II) with a tetrazole derivative (III) in the presence of a phase transfer catalyst.Type: ApplicationFiled: August 3, 2007Publication date: December 6, 2007Applicant: Otsuka Pharmaceutical Co., Ltd.Inventors: Shinji Aki, Muneaki Kurimura, Takao Nishi, Junichi Minamikawa, Michiaki Tominaga, Norihiro Fukuyama, Akihiro Yamamoto
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Publication number: 20070219374Abstract: The present invention provides an industrially advantageous method of producing aminophenol compounds represented by the formula (1) by a simple and easy procedure at a high yield and a high purity.Type: ApplicationFiled: March 25, 2005Publication date: September 20, 2007Inventors: Hiroshi Kiyokawa, Shinji Aki
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Publication number: 20070155787Abstract: The invention provides an amine salt of a carbostyril derivative formed from a carbostyril derivative represented by the formula (1) [wherein R is a halogen atom; the substituted position of the side chain is 3- or 4-position in the carbostyril skeleton; and the bonding between 3- and 4-positions of the carbostyril skeleton is a single bond or a double H bond] and an amine; and the invention is useful as drugs for treating various diseases, especially as aqueous formulations due to the superior water solubility and the superior pharmacologic effects.Type: ApplicationFiled: January 20, 2005Publication date: July 5, 2007Inventors: Yoshihiro Nishioka, Shinji Aki, Shigekazu Fujita, Yoshinao Onishi, Shun-ichiro Sumida
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Publication number: 20060100437Abstract: The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high purity. The carbostyril derivatives (I) can be produced by reacting a carbostyril derivative (II) with a tetrazole derivative (III) in the presence of a phase transfer catalyst.Type: ApplicationFiled: December 23, 2005Publication date: May 11, 2006Inventors: Shinji Aki, Muneaki Kurimura, Takao Nishi, Junichi Minamikawa, Michiaki Tominaga, Norihiro Fukuyama, Akihiro Yamamoto
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Publication number: 20050101631Abstract: The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high purity. The carbostyril derivatives (I) can be produced by reacting a carbostyril derivative (II) with a tetrazole derivative (III) in the presence of a phase transfer catalyst.Type: ApplicationFiled: December 20, 2004Publication date: May 12, 2005Inventors: Shinji Aki, Muneaki Kurimura, Takao Nishi, Junichi Minamikawa, Michiaki Tominaga, Norihiro Fukuyama, Akihiro Yamamoto
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Publication number: 20040059117Abstract: The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high purity. The carbostyril derivatives (I) can be produced by reacting a carbostyril derivative (II) with a tetrazole derivative (III) in the presence of a phase transfer catalyst.Type: ApplicationFiled: September 26, 2003Publication date: March 25, 2004Applicant: Otsuka Pharmaceuticals CompanyInventors: Shinji Aki, Muneaki Kurimura, Takao Nishi, Junichi Minamikawa, Michiaki Tominaga, Norihiro Fukuyama, Akihiro Yamamoto
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Publication number: 20040024017Abstract: The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high purity. The carbostyril derivatives (I) can be produced by reacting a carbostyril derivative (II) with a tetrazole derivative (III) in the presence of a phase transfer catalyst.Type: ApplicationFiled: August 1, 2002Publication date: February 5, 2004Inventors: Shinji Aki, Muneaki Kurimura, Takao Nishi, Junichi Minamikawa, Michiaki Tominaga, Norihiro Fukuyama, Akihiro Yamamoto
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Patent number: 6630590Abstract: The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high purity. The carbostyril derivatives (I) can be produced by reacting a carbostyril derivative (II) with a tetrazole derivative (III) in the presence of a phase transfer catalyst.Type: GrantFiled: August 1, 2002Date of Patent: October 7, 2003Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Shinji Aki, Muneaki Kurimura, Takao Nishi, Junichi Minamikawa, Michiaki Tominaga, Norihiro Fukuyama, Akihiro Yamamoto
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Publication number: 20030045547Abstract: The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high purity. The carbostyril derivatives (I) can be produced by reacting a carbostyril derivative (II) with a tetrazole derivative (III) in the presence of a phase transfer catalyst.Type: ApplicationFiled: August 5, 2002Publication date: March 6, 2003Inventors: Shinji Aki, Muneaki Kurimura, Takao Nishi, Junichi Minamikawa, Michiaki Tominaga, Norihiro Fukuyama, Akihiro Yamamoto
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Patent number: 4935420Abstract: Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.2 is a morpholino group which may be substituted by one to three C.sub.1 -C.sub.6 alkyl groups where each of the alkyl group may be substituted by 1 to 3 substituents selected from the group consisting of --NH.sub.2 and a halogen atom, and R.sup.3 is a C.sub.1 -C.sub.6 alkyl, --CH.sub.2 OH, ##STR2## (C.sub.1 -C.sub.6)alkylthiomethyl and --CH.sub.2 -halogen, or a pharmaceutically acceptable salt thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.Type: GrantFiled: October 17, 1988Date of Patent: June 19, 1990Assignee: Otsuka Pharmaceutical Company, Ltd.Inventors: Hiraki Ueda, Hisashi Miyamoto, Shinji Aki, Tatsuya Otsuka
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Patent number: 4880806Abstract: Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.2 is a heterocyclic group: ##STR2## in which R.sup.A is H, C.sub.1 -C.sub.6 alkyl or phenyl (C.sub.1 -C.sub.6) alkyl, R.sup.B is 2-oxo-1,3-dioxolenemethyl substituted by C.sub.1 -C.sub.6 alkyl, or C.sub.3 -C.sub.8 cycloalkyl, R.sup.C is H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxycarbonyl, or phenyl(C.sub.1 -C.sub.6)alkyl, R.sup.D is H or C.sub.1 -C.sub.6 alkyl, R.sup.G is C.sub.1 -C.sub.6 alkyl, and R.sup.H is C.sub.1 -C.sub.6 alkyl, phenyl(C.sub.1 -C.sub.6)alkyl, or C.sub.1 C.sub.6 alkanoyl, and R.sup.3 is C.sub.1 -C.sub.6 alkyl, or R.sup.3 is C.sub.1 -C.sub.6 alkyl having 1 to 3 substituents selected from OH, C.sub.1 -C.sub.6 alkoxy and halogen when R.sup.2 is ##STR3## or a salt thereof, said compounds having excellent antimicrobial activity and being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.Type: GrantFiled: July 23, 1987Date of Patent: November 14, 1989Assignee: Otsuka Pharmaceutical Company, LimitedInventors: Hiraki Ueda, Hisashi Miyamoto, Shinji Aki, Tatsuya Otsuka
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Patent number: 4874764Abstract: Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.3 is C.sub.1 -C.sub.6 alkyl and R.sup.F is C.sub.1 -C.sub.6 alkyl, and a pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.Type: GrantFiled: June 18, 1987Date of Patent: October 17, 1989Assignee: Otsuka Pharmaceutical Company, LimitedInventors: Hiraki Ueda, Hisashi Miyamoto, Shinji Aki, Tatsuya Otsuka