Patents by Inventor Shinji Hagiwara
Shinji Hagiwara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210386768Abstract: An object of the present invention is to provide a combination medicine that exhibits a practical curing effect on a tumor such as acute myeloid leukemia. According to the present invention, there is provided a combination medicine, which contains a compound represented by General Formula [1] specified in the present specification, such as (S,E)-N-(1-((5-(2-((4-cyanophenyl)amino)-4-(propylamino)pyrimidin-5-yl)-4-pentyn-1-yl)amino)-1-oxopropan-2-yl)-4-(dimethylamino)-N-methyl-2-butenamide or a salt thereof, and at least one selected from the group consisting of a BCL-2 inhibitor and a pyrimidine antimetabolite.Type: ApplicationFiled: August 27, 2021Publication date: December 16, 2021Applicant: FUJIFILM CorporationInventors: Hidetoshi MURAO, Hayato OGURA, Koichi SAITO, Shinji HAGIWARA, Takeshi YAMAURA, Toshiyuki NAKATANI, Hitoshi KIYOI, Yuichi ISHIKAWA
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Patent number: 9987278Abstract: Provided are a pharmaceutical composition for treating an FLT3 mutation-positive cancer; a mutant FLT3 inhibitor; and uses thereof.Type: GrantFiled: February 17, 2017Date of Patent: June 5, 2018Assignee: FUJIFILM CorporationInventors: Tomoki Naoe, Hitoshi Kiyoi, Shinji Hagiwara, Masaru Takasaki, Daisuke Hirano, Toshiyuki Nakatani, Takeshi Yamaura
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Publication number: 20170165262Abstract: Provided are a pharmaceutical composition for treating an FLT3 mutation-positive cancer; a mutant FLT3 inhibitor; and uses thereof.Type: ApplicationFiled: February 17, 2017Publication date: June 15, 2017Applicant: FUJIFILM CorporationInventors: Tomoki NAOE, Hitoshi KIYOI, Shinji HAGIWARA, Masaru TAKASAKI, Daisuke HIRANO, Toshiyuki NAKATANI, Takeshi YAMAURA
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Patent number: 9051310Abstract: The object of the present invention is to provide a compound and a pharmaceutical composition having excellent Syk inhibitory activity. According to the present invention, a nicotinamide derivative represented by the following formula (I) or a salt thereof is provided, wherein R1 is a substituent represented by the following formula (II-1), (III-1), or (IV-1) (wherein R3, R4, R5, n, and X1 have the same definitions as those described in the specification), and R2 is a pyridyl, indazolyl, phenyl, pyrazolopyridyl, benzisoxazolyl, pyrimidinyl, or quinolyl group, each of which optionally has at least one substituent.Type: GrantFiled: June 27, 2014Date of Patent: June 9, 2015Assignee: FUJIFILM CorporationInventors: Hideyasu Fujiwara, Shinsuke Mizumoto, Yohei Kubo, Hiyoku Nakata, Shinji Hagiwara, Yasutaka Baba, Takashi Tamura, Hidenobu Kuniyoshi, Tomoyuki Mashiko, Mari Yamamoto
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Patent number: 8895585Abstract: An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.Type: GrantFiled: December 28, 2012Date of Patent: November 25, 2014Assignee: FUJIFILM CorporationInventors: Hideyasu Fujiwara, Kimihiko Sato, Shinsuke Mizumoto, Yuichiro Sato, Hideki Kurihara, Yohei Kubo, Hiyoku Nakata, Yasutaka Baba, Takashi Tamura, Hidenobu Kuniyoshi, Shinji Hagiwara, Mari Yamamoto
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Publication number: 20140309225Abstract: The object of the present invention is to provide a compound and a pharmaceutical composition having excellent Syk inhibitory activity. According to the present invention, a nicotinamide derivative represented by the following formula (I) or a salt thereof is provided, wherein R1 is a substituent represented by the following formula (II-1), (III-1), or (IV-1) (wherein R3, R4, R5, n, and X1 have the same definitions as those described in the specification), and R2 is a pyridyl, indazolyl, phenyl, pyrazolopyridyl, benzisoxazolyl, pyrimidinyl, or quinolyl group, each of which optionally has at least one substituent.Type: ApplicationFiled: June 27, 2014Publication date: October 16, 2014Applicant: FUJIFILM CorporationInventors: Hideyasu FUJIWARA, Shinsuke MIZUMOTO, Yohei KUBO, Hiyoku NAKATA, Shinji HAGIWARA, Yasutaka BABA, Takashi TAMURA, Hidenobu KUNIYOSHI, Tomoyuki MASHIKO, Mari YAMAMOTO
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Patent number: 8809371Abstract: An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.Type: GrantFiled: December 28, 2012Date of Patent: August 19, 2014Assignee: FUJIFILM CorporationInventors: Hideyasu Fujiwara, Kimihiko Sato, Shinsuke Mizumoto, Yuichiro Sato, Hideki Kurihara, Yohei Kubo, Hiyoku Nakata, Yasutaka Baba, Takashi Tamura, Hidenobu Kuniyoshi, Shinji Hagiwara, Mari Yamamoto
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Patent number: 8772320Abstract: An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.Type: GrantFiled: December 28, 2012Date of Patent: July 8, 2014Assignee: FUJIFILM CorporationInventors: Hideyasu Fujiwara, Kimihiko Sato, Shinsuke Mizumoto, Yuichiro Sato, Hideki Kurihara, Yohei Kubo, Hiyoku Nakata, Yasutaka Baba, Takashi Tamura, Hidenobu Kuniyoshi, Shinji Hagiwara, Mari Yamamoto
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Publication number: 20130116430Abstract: An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.Type: ApplicationFiled: December 28, 2012Publication date: May 9, 2013Applicant: FUJIFILM CORPORATIONInventors: Hideyasu FUJIWARA, Kimihiko SATO, Shinsuke MIZUMOTO, Yuichiro SATO, Hideki KURIHARA, Yohei KUBO, Hiyoku NAKATA, Yasutaka BABA, Takashi TAMURA, Hidenobu KUNIYOSHI, Shinji HAGIWARA, Mari YAMAMOTO
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Publication number: 20110014411Abstract: The present invention disclose a pressure-sensitive adhesive sheet having the adhesive layer on at least one surface of the substrate, characterized in that in particular the above adhesive layer has a number of trunk-like grooves which lead to the end of the above sheet, and a number of branch-like grooves with closed terminals which branch from the trunk-like grooves. This structure provides effects in that it can be applied easily and smoothly without retaining air when adhering to an adherend and additionally the appearance of the pressure-sensitive adhesive sheet is not damaged after adhering.Type: ApplicationFiled: March 17, 2009Publication date: January 20, 2011Applicant: LINTEC CORPORATIONInventors: Shinji Hagiwara, Toshimitsu Kanda
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Publication number: 20100092730Abstract: An adhesive sheet which can be produced without using a release sheet having an uneven surface form and which can prevent or remove air bubbles and blisters and a process for producing the same are provided by an adhesive sheet prepared by laminating a non-permeable adhesive layer in which both surfaces are flat on an uneven surface of a base material having concave and convex parts in which adjacent concave parts are communicated with each other at least on one surface so that the adhesive layer is brought into contact with the convex part of the base material and a process comprising laminating a release sheet provided on a release treated surface with a non-permeable adhesive layer in which both surfaces are flat and a base material having concave and convex parts in which adjacent concave parts are communicated with each other at least on one surface so that the non-permeable adhesive layer is brought into contact with the convex part of the base material.Type: ApplicationFiled: December 21, 2007Publication date: April 15, 2010Applicant: LINTEC CORPORATIONInventors: Tadahiro Tomino, Koji Tabata, Shinji Hagiwara, Toshihiro Tsutsui
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Patent number: 5490573Abstract: A pair of air inlet openings and a pair of air introduction paths are formed in a leftwardly and rightwardly symmetrical relationship on left and right side portions of a windshield. The air introduction paths are each formed as a smooth continuous curved face in a transverse direction, and a body center side curved face of the air introduction path is formed more moderate relative to an outer side curved face. When surface air flows along the surface of the front face flow on the air introduction paths since the body center side curved faces are moderate, exfoliation occurs less likely, and the external air admission efficiency of the air inlet openings is raised.Type: GrantFiled: September 22, 1994Date of Patent: February 13, 1996Assignee: Honda Giken Kogyo Kabushiki KaishaInventors: Shinji Hagiwara, Kouichi Kobayashi, Kouji Shimokawa, Kenichi Nishimoto