Abstract: The invention of the present application intends to provide a work machine that can ensure high operability by preventing abrupt actuation of an actuator and a shock to a machine body by use of a bleed-off function at the time of starting of the actuator and that can improve the energy-saving performance by reducing a bleed-off flow rate after the starting of the actuator. For this purpose, a controller opens a bleed-off valve at a timing at which an operation device is being operated and before a flow rate of a hydraulic pump starts increasing, and closes the bleed-off valve at a timing at which the operation device is being operated and after the flow rate of the hydraulic pump has started increasing.

Abstract: A heat insulating material (1) includes a heat insulating layer (10) which has a porous structural body, a reinforcing fiber, and nanoparticles of a metal oxide used as a binder, wherein the porous structural body has a skeleton formed by connecting a plurality of particles, has pores inside, and has a hydrophobic portion on at least one surface between a surface and an inside of the porous structural body. The heat insulating layer (10) has a mass loss rate of 10% or less in thermogravimetric analysis held at 500° C. for 30 minutes.

Abstract: An object of the present invention is to provide a compound, a method and a pharmaceutical composition for normalizing double homeobox 4 (DUX4) of an individual in which the DUX4 gene has abnormally expressed. Provided is a modified oligonucleotide consisting of 12-30 residues. The modified oligonucleotide includes a nucleobase sequence that includes at least 8 contiguous nucleobase sequences and is complementary to an equal length portion at positions 126-147, 232-248, 1306-1325 or 1472-1495 from a 5? end of a nucleobase of a mature mRNA of DUX4 of SEQ ID NO: 1. The nucleobase sequence of the modified oligonucleotide has at least 90% complementarity to the equal length portion in the nucleobase sequence of the mature mRNA of DUX4 of SEQ ID NO: 1.

Abstract: A thermal insulation material for a battery pack includes: a thermal insulation layer; and a first base material and a second base material that are arranged with the thermal insulation layer interposed therebetween. The thermal insulation layer contains a porous structure in which a plurality of particles is connected to form a skeleton, reinforcing fibers, and metal oxide nanoparticles serving as a binder, the porous structure having pores inside and having hydrophobic sites at least on a surface of the porous structure out of the surface and inside of the porous structure, and a percentage mass loss of the thermal insulation layer in thermogravimetric analysis in which the thermal insulation layer is held at 500° C. for 30 minutes is 10% or less.

Abstract: The present invention provides a novel bridged artificial nucleic acid and an oligomer containing the same as a monomer. The present invention provides specifically a compound represented by general formula (I) (wherein each symbol is the same as defined in the specification) or salts thereof; as well as an oligonucleotide compound represented by general formula (I?) (wherein each symbol is the same as defined in the specification) or salts thereof.

Abstract: A heat insulating material (1) includes a heat insulating layer (10) which has a porous structural body, a reinforcing fiber, and nanoparticles of a metal oxide used as a binder, wherein the porous structural body has a skeleton formed by connecting a plurality of particles, has pores inside, and has a hydrophobic portion on at least one surface between a surface and an inside of the porous structural body. The heat insulating layer (10) has a mass loss rate of 10% or less in thermogravimetric analysis held at 500° C. for 30 minutes.

Abstract: A method for preparing a compound represented by general formula I: or a salt thereof includes a step of reacting a compound represented by formula II: with a reducing agent to cleave an oxazolidine ring fused to a cycle A?. The reducing agent includes at least one of phosphines, metal hydrides, or transition metal catalysts in the presence of hydrogen gas.

Abstract: A vehicle rear structure includes a pair of rear side frames provided on right and left sides at a rear part of a vehicle body, and an on-board component disposed between the rear side frames. Each rear side frame includes a protecting part arranged side by side with the on-board component in a vehicle width direction, and a rear extending part extending rearward from the on-board component. A cross member is provided to connect the rear extending parts to each other at positions each located away from a front end and a rear end of the corresponding rear extending part.

Abstract: A vehicle rear structure includes: a pair of rear side frames provided on right and left sides at a rear part of a vehicle body; side sills connected to front parts of the rear side frames and extending on the right and left sides of the vehicle body, respectively; and an on-board component, at least part of which is arranged side by side with the rear side frames in a vehicle width direction. Each side sill includes a weak part located ahead of the on-board component and having a lower strength than a strength of a region of the rear side frame arranged side by side with the on-board component.

Abstract: A vehicle body rear structure includes: a pair of left and right rear side frames extending in a vehicle front-rear direction; a vehicle-mounted component provided between the pair of rear side frames; and a pair of support members for supporting the vehicle-mounted component. The support members respectively extend along the rear side frames and in the vehicle front-rear direction, and are respectively arranged side-by-side with the rear side frames in a vehicle width direction and inwardly of the rear side frames in the vehicle width direction.

Abstract: A vehicle body rear structure includes: a pair of left and right rear side frames extending in a vehicle front-rear direction; a vehicle-mounted component provided between the pair of rear side frames; and a pair of support members for supporting the vehicle-mounted component. The support members respectively extend along the rear side frames and in the vehicle front-rear direction, and are respectively arranged side-by-side with the rear side frames in a vehicle width direction and inwardly of the rear side frames in the vehicle width direction.

Abstract: A vehicle rear structure includes: a pair of rear side frames provided on right and left sides at a rear part of a vehicle body; side sills connected to front parts of the rear side frames and extending on the right and left sides of the vehicle body, respectively; and an on-board component, at least part of which is arranged side by side with the rear side frames in a vehicle width direction. Each side sill includes a weak part located ahead of the on-board component and having a lower strength than a strength of a region of the rear side frame arranged side by side with the on-board component.

Abstract: A vehicle rear structure includes a pair of rear side frames provided on right and left sides at a rear part of a vehicle body, and an on-board component disposed between the rear side frames. Each rear side frame includes a protecting part arranged side by side with the on-board component in a vehicle width direction, and a rear extending part extending rearward from the on-board component. A cross member is provided to connect the rear extending parts to each other at positions each located away from a front end and a rear end of the corresponding rear extending part.

Abstract: A dielectric film includes an elastomer, and metallic oxide particles having a particle diameter of 100 nm or less that are chemically bonded to the elastomer and are dispersed in the elastomer in a state of primary particles. A method for manufacturing the dielectric film includes: a chelating process of adding a chelating agent to an organometallic compound to produce a chelate compound of the organometallic compound; a sol manufacturing process of adding an organic solvent and water to the chelate compound to obtain a sol of metallic oxide particles produced by the hydrolytic reaction of the organometallic compound; a mixed solution preparing process of mixing the sol of the metallic oxide particles and a polymer solution containing a rubber polymer having functional groups that optionally react with hydroxy groups; and a film forming process of applying the mixed solution onto a substrate, and curing the resultant coating film.

Abstract: A dielectric material for a transducer is manufactured from a composition that includes metal oxide particles having hydroxy groups, a rubber polymer having a functional group capable of reacting with an epoxy group, a bisphenol type epoxy resin, both ends of which have an epoxy group, and a cross-linking agent. In the dielectric material for a transducer, the metal oxide particles are bound to the rubber polymer via the bisphenol type epoxy resin. A transducer includes a dielectric layer made of the dielectric material for a transducer and a plurality of electrodes arranged with the dielectric layer interposed therebetween.

Abstract: The present invention provides a method for producing guanidine crosslinked artificial nucleic acid (abbreviated hereinafter as GuNA), and an intermediate compound for the production thereof. Specifically, the present invention provides a method for producing a compound represented by general formula I: (in the formula, R1, R2, R3, R4, R5, R6, m and ring A are as defined in the specification) or a salt thereof wherein a reducing agent is reacted with a compound represented by general formula II: (in the formula, R1, R2, R3, R4, R5, R6, m, and ring A? are as defined in the specification).

Abstract: A dielectric material for a transducer is manufactured from a composition that includes metal oxide particles having hydroxy groups, a rubber polymer having a functional group capable of reacting with an epoxy group, a bisphenol type epoxy resin, both ends of which have an epoxy group, and a cross-linking agent. In the dielectric material for a transducer, the metal oxide particles are bound to the rubber polymer via the bisphenol type epoxy resin. A transducer includes a dielectric layer made of the dielectric material for a transducer and a plurality of electrodes arranged with the dielectric layer interposed therebetween.

Abstract: A dielectric film includes an elastomer, and metallic oxide particles having a particle diameter of 100 nm or less that are chemically bonded to the elastomer and are dispersed in the elastomer in a state of primary particles. A method for manufacturing the dielectric film includes: a chelating process of adding a chelating agent to an organometallic compound to produce a chelate compound of the organometallic compound; a sol manufacturing process of adding an organic solvent and water to the chelate compound to obtain a sol of metallic oxide particles produced by the hydrolytic reaction of the organometallic compound; a mixed solution preparing process of mixing the sol of the metallic oxide particles and a polymer solution containing a rubber polymer having functional groups that optionally react with hydroxy groups; and a film forming process of applying the mixed solution onto a substrate, and curing the resultant coating film.

Abstract: A transducer includes a high-resistance layer that includes an elastomer and has a volume resistivity of 1012 ?·cm or more, a pair of electrodes that are arranged on both a front side and a back side of the high-resistance layer and include a binder and a conductive material, and a medium-resistance layer that is interposed between the electrode and the high-resistance layer on at least one of the front side and the back side of the high-resistance layer, includes an elastomer, and has a volume resistivity that is smaller than the volume resistivity of the high-resistance layer by two or more digits. In the transducer, the medium-resistance layer is interposed between at least one electrode and the high-resistance layer to take advantage of the resistance to dielectric breakdown originally possessed by the high-resistance layer, thereby obtaining a larger force by applying a higher voltage.

Abstract: An elastomer material containing immobilized ionic components includes an elastomer, ion-immobilized particles in which first ionic components are immobilized to metallic oxide particles, and second ionic components having electric charges opposite to electric charges of the first ionic components, wherein the ion-immobilized particles are chemically bonded to the elastomer. In the elastomer material, the first ionic components are immobilized to the elastomer through the metallic oxide particles. Therefore, the first ionic components do not easily migrate even with the passage of time or in use. Thus, the elastomer material is less susceptible to temporal changes in properties. The elastomer material is preferably used for the component of a transducer and a conductive roll.