Patents by Inventor Shinji Shigenaga
Shinji Shigenaga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110166161Abstract: This invention relates to novel heterocyclic carboxamide derivatives and salts thereof. More particularly, it relates to novel heterocyclic carboxamide derivatives and salts thereof which act as a ROCK inhibitor, to a pharmaceutical composition comprising the same and to a method of using the same therapeutically in the treatment and/or prevention of ROCK-related disease.Type: ApplicationFiled: September 17, 2009Publication date: July 7, 2011Applicant: Astellas Pharma Inc.Inventors: Takeshi Terasawa, Shinji Shigenaga, Shinji Itoh, Jun Maeda, Hideyuki Watanabe, Satoshi Kubo, Noe Iahii
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Publication number: 20070123532Abstract: This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.Type: ApplicationFiled: November 21, 2006Publication date: May 31, 2007Applicant: Fujisawa Pharmaceutical Co. Ltd.Inventors: Kazuhiko Take, Nobukiyo Konishi, Shinji Shigenaga, Natsuko Kayakiri, Hidenori Azami, Yoshiteru Eikyu, Kazuo Nakai, Junya Ishida, Masataka Morita
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Patent number: 7166598Abstract: This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.Type: GrantFiled: October 20, 2004Date of Patent: January 23, 2007Assignee: Astellas Pharma Inc.Inventors: Kazuhiko Take, Nobukiyo Konishi, Shinji Shigenaga, Natsuko Kayakiri, Hidenori Azami, Yoshiteru Eikyu, Kazuo Nakai, Junya Ishida, Masataka Morita
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Publication number: 20060014948Abstract: This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.Type: ApplicationFiled: October 20, 2004Publication date: January 19, 2006Applicant: Fujisawa Pharmaceutical Co. Ltd.Inventors: Kazuhiko Take, Nobukiyo Konishi, Shinji Shigenaga, Natsuko Kayakiri, Hidenori Azami, Yoshiteru Eikyu, Kazuo Nakai, Junya Ishida, Masataka Morita
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Publication number: 20050171350Abstract: A compound of the formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.Type: ApplicationFiled: December 16, 2002Publication date: August 4, 2005Applicant: Fujisawa Pharamaceutical Co., Ltd.Inventors: Kazuhiko Take, Chiyoshi Kasahara, Shinji Shigenaga, Yoshiteru Eikyu, Takashi Tojo
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Patent number: 6924278Abstract: This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.Type: GrantFiled: November 24, 2003Date of Patent: August 2, 2005Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hiroshi Miyake, Kazuhiko Take, Shinji Shigenaga, Hidenori Azami, Hiroshi Sasaki, Yoshiteru Eikyu, Kazuo Nakai, Junya Ishida, Takashi Manabe, Nobukiyo Konishi, Tadashi Terasaka
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Publication number: 20050027121Abstract: This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.Type: ApplicationFiled: November 24, 2003Publication date: February 3, 2005Applicant: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hiroshi Miyake, Kazuhiko Take, Shinji Shigenaga, Hidenori Azami, Hiroshi Sasaki, Yoshiteru Eikyu, Kazuo Nakai, Junya Ishida, Takashi Manabe, Nobukiyo Konishi, Tadashi Terasaka
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Publication number: 20040220403Abstract: A compound of the formula (I): wherein in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.Type: ApplicationFiled: June 30, 2003Publication date: November 4, 2004Inventors: Kazuhiko Take, Chiyoshi Kasahara, Shinji Shigenaga, Hidenori Azami, Yoshiteru Eikyu, Kazuo Nakai, Masataka Morita
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Patent number: 6787543Abstract: A compound of the formula (I): in which Z, R1, R2, R8, R10, R11, R12, R13 and R14 are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.Type: GrantFiled: December 20, 2002Date of Patent: September 7, 2004Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kazuhiko Take, Chiyoshi Kasahara, Shinji Shigenaga, Hidenori Azami, Yoshiteru Eikyu, Kazuo Nakai, Masataka Morita
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Publication number: 20030176430Abstract: A compound of the formula (I): in which Z, R1, R2, R8, R10, R11, R12, R13 and R14 are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.Type: ApplicationFiled: December 20, 2002Publication date: September 18, 2003Inventors: Kazuhiko Take, Chiyoshi Kasahara, Shinji Shigenaga, Hidenori Azami, Yoshiteru Eikyu, Kazuo Nakai, Masataka Morita
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Publication number: 20030114668Abstract: This invention relates to piperazine derivatives of formula (I), wherein Y is bond or lower alkylene, R1 is aryl which may have substituent(s), R2 is aryl or indolyl, each of which may have substituent(s), R3 is hydrogen or lower alkyl, and R4 is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human beings or animals.Type: ApplicationFiled: January 7, 2000Publication date: June 19, 2003Inventors: HIROSHI MIYAKE, KAZUHIKO TAKE, SHINJI SHIGENAGA, HIDENORI AZAMI, HIROSHI SASAKI, YOSHITERU EIKYU, KAZUO NAKAI, JUNYA ISHIDA, TAKASHI MANABE, NOBUKIYO KONISHI, TADASHI TERASAKA
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Publication number: 20020010182Abstract: This invention relates to piperazine derivatives of the formula: 1Type: ApplicationFiled: July 9, 2001Publication date: January 24, 2002Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.Inventors: Matsuo Masaaki, Takashi Manabe, Nobukiyo Konishi, Kazuhiko Take, Norihiro Igari, Shinji Shigenaga, Hiroshi Matsuda, Tadashi Terasaka
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Patent number: 6087357Abstract: This application is a 371 of PCT/JP96/03641 filed Dec. 12, 1996.Type: GrantFiled: June 18, 1998Date of Patent: July 11, 2000Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masaaki Matsuo, Takashi Manabe, Nobukiyo Konishi, Kazuhiko Take, Norihiro Igari, Shinji Shigenaga, Hiroshi Matsuda, Tadashi Terasaka
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Patent number: 5994378Abstract: This invention relates to novel thiazolylbenzofuran derivatives of formula (I) wherein R.sup.1 is lower alkyl, L is single bond or lower alkylene optionally substituted with aryl, oxo or hydroxy, and Q is a heterocyclic group optionally substituted with one or more suitable substituent(s); or lower alkoxy substituted with aryl which is substituted with one or more suitable substituent(s) and at least one of which is lower alkoxy optionally substituted with cyano, protected carboxy, carboxy, lower alkylene, a heterocyclic group optionally substituted with oxo, or amidino optionally substituted with hydroxy or lower alkoxy, or its salt, which possess activities as leukotriene and SRS-A antagonists or inhibitors.Type: GrantFiled: July 21, 1998Date of Patent: November 30, 1999Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masaaki Matsuo, Kazuo Okumura, Shinji Shigenaga, Hiroaki Nishimura, Hiroshi Matsuda, Daijiro Hagiwara, Tadashi Terasaka
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Patent number: 5939413Abstract: This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or Tachykinin-mediated diseases in human beings or animals.Type: GrantFiled: November 24, 1997Date of Patent: August 17, 1999Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masaaki Matsuo, Daijiro Hagiwara, Takashi Manabe, Nobukiyo Konishi, Shinji Shigenaga, Kenji Murano, Hiroshi Matsuda, Hiroshi Miyake
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Patent number: 5883098Abstract: A piperazine compound of the formula: ##STR1## wherein: X is carbonyl or sulfonyl;Y is a direct bond or lower alkylene; andR.sub.1, R.sub.2, R.sub.3, R.sub.4 are as defined herein. The compounds are advantageously used as Tachykinin antagonists in the treatment of respiratory diseases, ophthalmic diseases and inflammatory diseases, for example.Type: GrantFiled: June 27, 1997Date of Patent: March 16, 1999Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masaaki Matsuo, Daijiro Hagiwara, Takashi Manabe, Nobukiyo Konishi, Shinji Shigenaga, Kenji Murano, Hiroshi Matsuda, Hiroshi Miyake
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Patent number: 5670505Abstract: A piperazine compound of the formula: ##STR1## wherein: X is carbonyl or sulfonyl;Y is a direct bond or lower alkylene; andR.sub.1, R.sub.2, R.sub.3, R.sub.4 are as defined herein. The compounds are advantageously used as Tachykinin antagonists in the treatment of respiratory diseases, ophthalmic diseases and inflammatory diseases, for example.Type: GrantFiled: November 28, 1994Date of Patent: September 23, 1997Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masaaki Matsuo, Daijiro Hagiwara, Takashi Manabe, Nobukiyo Konishi, Shinji Shigenaga, Kenji Murano, Hiroshi Matsuda, Hiroshi Miyake
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Patent number: 5661159Abstract: This invention relates to new quinolylbenzofuran derivatives having activities as leukotrien and Slow Reacting Substance of Anaphylaxis antagonists and inhibitors and represented by the general formula (I): ##STR1## wherein R.sup.1 is halogen, etc.,R.sup.2 is hydrogen or halogen,R.sup.3 is hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy,R.sup.4 is hydrogen, acyl, cyano, nitro, substituted or unsubstituted aryl, or substituted or unsubstituted lower alkyl,R.sup.5 is hydrogen, hydroxy, lower alkyl or lower alkoxy,A is lower alkylene, lower alkenylene or a single bond,X is a single bond, O, NH, S, SO or SO.sub.2, andY is O or S,provided that when R.sup.3 is hydrogen, R.sup.4 is hydrogen,R.sup.5 is hydrogen, A is a single bond and X is a single bond, then R.sup.1 is halogen, etc.,and pharmaceutically acceptable salts thereof to processes for the preparation thereof and to a pharmaceutical composition comprising the same.Type: GrantFiled: August 2, 1994Date of Patent: August 26, 1997Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masaaki Matsuo, Kazuo Okumura, Shinji Shigenaga
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Patent number: 5296495Abstract: Compounds of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, A, X and Y are as defined and pharmaceutically acceptable salts thereof; which have activities as leukotriene and Slow Reacting Substance of Anaphalaxis (SRS-a) antagonists or inhibitors, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to methods of using the same therapeutically in the prevention and/or treatment of allergy or inflamation in human beings or animals.Type: GrantFiled: August 12, 1992Date of Patent: March 22, 1994Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masaaki Matsuo, Kazuo Okumura, Shinji Shigenaga, Hiroshi Matsuda
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Patent number: 5017703Abstract: The invention relates to novel indolylpiperidine compounds useful in the treatment of allergic disease and inflammation.Type: GrantFiled: September 28, 1989Date of Patent: May 21, 1991Assignee: Fujisawa Pharmaceutical Company, Ltd.Inventors: Masaaki Matsuo, Takashi Manabe, Shinji Shigenaga, Hiroshi Matsuda