Abstract: An object of the present invention is to provide an anti-tumor agent that exhibits a remarkably excellent anti-tumor effect. According to the present invention, there is provided an anti-tumor agent for curing cancer, the anti-tumor agent having a liposome which has an inner water phase and having an aqueous solution which is an outer water phase and disperses the liposome, in which the liposome encompasses topotecan or a salt thereof, a lipid constituting the liposome contains a lipid modified with polyethylene glycol, dihydrosphingomyelin, and cholesterol, the inner water phase contains an ammonium salt, and the topotecan or the salt thereof encompassed in the liposome is administered at a dose rate of 0.1 mg/m2 body surface area to 10 mg/m2 body surface area, in terms of topotecan per administration.

Abstract: The present invention relates to a reservoir tank for coolant that stores the coolant for cooling an internal combustion engine. The reservoir tank includes: a tank chamber that stores the coolant; an opening, which is disposed in an upper part of the tank chamber, through which the coolant flows in and flows out, and in a circumferential wall of which a breathing hole is formed; and a first communication passage, a second communication passage, and a third communication passage that respectively communicate with the opening and the tank chamber.

Abstract: An expansion tank, includes: a tank main body defining a storage chamber storing a coolant liquid therein; multiple partition walls provided in the tank main body to divide the storage chamber into multiple division chambers including an inlet chamber and an outlet chamber, the partition walls being formed with communication holes for bringing adjacent ones of the division chambers into communication with each other; a coolant liquid inlet portion that is provided on the tank main body and is open to the inlet chamber; a coolant liquid outlet portion that has an outlet opening in a depression formed in a bottom of the tank main body and is open to the outlet chamber; and a barrier wall extending from a side wall of the tank main body or one of the partition walls into the depression.

Abstract: An expansion tank, includes: a tank main body defining a storage chamber storing a coolant liquid therein; multiple partition walls provided in the tank main body to divide the storage chamber into multiple division chambers including an inlet chamber and an outlet chamber, the partition walls being formed with communication holes for bringing adjacent ones of the division chambers into communication with each other; a coolant liquid inlet portion that is provided on the tank main body and is open to the inlet chamber; a coolant liquid outlet portion that has an outlet opening in a depression formed in a bottom of the tank main body and is open to the outlet chamber; and a barrier wall extending from a side wall of the tank main body or one of the partition walls into the depression.

Abstract: An expansion tank includes a plurality of partition walls separating a storage chamber of the tank main body into a plurality of compartment chambers, each partition wall provided with a lower communicating portion and an upper communicating portion formed in a lower part and an upper part thereof, respectively, to communicate the adjoining compartment chambers to each other, wherein the compartment chambers include an inlet chamber having an inlet, an outlet chamber having an outlet, and intermediate chambers, and wherein one of the compartment chambers other than the outlet chamber is provided with a communication port, and a lower edge of the upper communicating portion of the partition wall defining the compartment chamber provided with the communication port is lower than a lower edge of the upper communicating portion of another one of the partition walls.

Abstract: An internal combustion engine includes a deactivatable cylinder group, a constantly operating cylinder group, a first water passage, a second water passage, an upstream integrated water passage, a downstream integrated water passage, a connecting passage, a third water passage, and a device. The downstream integrated water passage includes a junction and an upstream end. The upstream end is closer to the second water passage than to the first water passage in the downstream integrated water passage. The third water passage connects the connecting passage and a portion provided between the junction and the upstream end in the downstream integrated water passage. The device is provided adjacent to at least a part of the third water passage to exchange heat with water flowing in the third water passage.

Abstract: An internal combustion engine includes a deactivatable cylinder group, a constantly operating cylinder group, a first water passage, a second water passage, an upstream integrated water passage, a downstream integrated water passage, a connecting passage, a third water passage, and a device. The downstream integrated water passage includes a junction and an upstream end. The upstream end is closer to the second water passage than to the first water passage in the downstream integrated water passage. The third water passage connects the connecting passage and a portion provided between the junction and the upstream end in the downstream integrated water passage. The device is provided adjacent to at least a part of the third water passage to exchange heat with water flowing in the third water passage.