Abstract: The present invention relates to a crosslinked gelatin support, in which a surface of a crosslinked gelatin is negatively charged and has a zeta potential in ethanol of from ?3 to ?50 mV, and a support for controlled release of a physiologically active substance, including: the crosslinked gelatin support; and a physiologically active substance adsorbed and retained on and/or inside the crosslinked gelatin support.

Abstract: A droplet formation device 1 includes: a base member 2 formed of stacked substrates including a middle substrate 21 and a lower substrate 23; a passage structure 211 formed on the middle substrate 21 and including droplet formation passages through which a liquid dispersed-phase material and a liquid continuous-phase material flow to form droplets of the dispersed-phase material using a shear force of the continuous-phase material; a liquid storage part 231 formed on the lower substrate 23 and storing the liquid dispersed-phase material 200 and the liquid of the continuous-phase material 100; dispersed-phase material supply parts through which the liquid dispersed-phase material 200 is supplied from the liquid storage part 231 to the droplet formation passages of the passage structure 211; and continuous-phase material supply parts through which the continuous-phase material 100 is supplied from the liquid storage part 231 to the droplet formation passages of the passage structure 211.

Abstract: The present invention relates to a crosslinked gelatin support, in which a surface of a crosslinked gelatin is negatively charged and has a zeta potential in ethanol of from ?3 to ?50 mV, and a support for controlled release of a physiologically active substance, including: the crosslinked gelatin support; and a physiologically active substance adsorbed and retained on and/or inside the crosslinked gelatin support.

Abstract: The present invention relates to a gelatin particle, which is a thermally crosslinked non-porous spherical gelatin particle having a circularity of 0.8 or more and a dry particle diameter of 20 to 1,600 ?m. The average volume swelling ratio of the gelatin particle in a case where the gelatin particle is immersed in physiological saline at 23° C. is from 200 to 2,000% relative to an average volume of the gelatin particle in a dried state. As for a swollen gelatin particle, it is preferable that the gelatin used has a jelly strength of 80 to 120 g and the swollen gelatin particle has a particle diameter of 50 to 2,000 ?m. The gelatin particle can be used for blood vessel embolization and also for controlled release of physiologically active substance.