Abstract: The present invention provides a compound which has an effect of inhibiting amyloid ßproduction, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid ßproteins. A compound of Formula (I) wherein R3 is each independently alkyl optionally substituted with halogen, cyano, alkyloxy, haloalkyloxy or non-aromatic carbocyclyl, or the like; t is integer from 0 to 3; R5 is a hydrogen atom or halogen; R6 is selected from the group consisting of a hydrogen atom, halogen, and substituted or unsubstituted alkyl; ring B is a substituted or unsubstituted pyrazine or the like; or a pharmaceutically acceptable salt thereof.

Abstract: A second conductor, third conductor, and fourth conductor sandwiches a first layer together with a first semiconductor. The fourth conductor is positioned farther from the first conductor than the third conductor, which is positioned farther from first conductor than the second conductor. A first circuit is configured to apply a first potential to the first and second conductors, apply a second potential lower than the first potential to the third conductor in parallel with the application of the first potential, and apply a third potential higher than the second potential and lower than the first potential to the fourth conductor in parallel with the application of the first potential.

Abstract: A method of adjusting operating conditions includes: a substrate; first conductive layers; a first semiconductor layers facing the first conductive layers; a second semiconductor layer connected to the first semiconductor layers; and an electric charge accumulating layer disposed between the first conductive layers and the first semiconductor layers. At a predetermined timing of a program operation, the second conductive layer which is one of the first conductive layers is supplied with a program voltage or a write pass voltage. The method executes: a first operation that supplies the second conductive layer with the write pass voltage and supplies a third conductive layer which is one of the plurality of first conductive layers with the program voltage; and a second operation that supplies the second conductive layer with a verify voltage and supplies the third conductive layer with a voltage.

Abstract: A semiconductor memory device includes a substrate, gate electrodes, a semiconductor layer opposed to gate electrodes, an electric charge accumulating layer disposed between gate electrodes and the semiconductor layer, a conductive layer connected to one end portion of the semiconductor layer, and a control circuit electrically connected to gate electrodes and the conductive layer. Gate electrodes include first gate electrodes, second gate electrodes, and third gate electrode. The control circuit is configured to perform an erase operation. The erase operation includes: at least one-time first operation that applies a first voltage to the conductive layer; a second operation performed after the first operation, the second operation applying a second voltage to the third gate electrode; and at least one-time third operation performed after the second operation, the third operation applying a third voltage same as or larger than the first voltage to the conductive layer.

Abstract: This disc brake includes a mounting member, a pair of brake pads, a caliper, a cover member, and a locking member. The caliper includes a cylinder part having a cylinder hole in which a piston for moving one of the pair of brake pads is disposed, a bridge part extending across an outer circumferential surface of a disc from the cylinder part, a plurality of claw parts formed on an extended distal end side of the bridge part and disposed to face the cylinder part, and a recessed part provided between the plurality of claw parts, having an opening at a disc radial direction inner end, and formed to face the cylinder hole. The locking member includes a fixing part fixed to the cover member, and a plurality of locking pieces extending from the fixing part in a direction inclined with respect to a movement direction of the piston.

Abstract: Provided is a microchip that can achieve a favorable bonding state in the bonding portion between first and second substrates even if the microchip is large in size. A microchip includes a first substrate made of a resin and a second substrate made of a resin, the first substrate and the second substrates being bonded to each other, and a channel surrounded by a bonding portion between the first substrate and the second substrate is formed by a channel forming step formed at least in the first substrate. Further, a noncontact portion is formed to surround the bonding portion, and an angle ?1 formed between a side wall surface of the channel forming step and a bonding surface continuous therewith satisfies ?1>90°.

Abstract: A device includes an external sensor to scan an environment so as to periodically output scan data, a storage to store an environmental map, and a location estimation device to match the sensor data against the environmental map read from the storage so as to estimate a location and an attitude of the vehicle. The location estimation device determines predicted values of a current location and a current estimation of the vehicle in accordance with a history of estimated locations and estimated attitudes of the vehicle, and performs the matching by using the predicted values.

Abstract: A method of adjusting operating conditions includes: a substrate; first conductive layers; a first semiconductor layers facing the first conductive layers; a second semiconductor layer connected to the first semiconductor layers; and an electric charge accumulating layer disposed between the first conductive layers and the first semiconductor layers. At a predetermined timing of a program operation, the second conductive layer which is one of the first conductive layers is supplied with a program voltage or a write pass voltage. The method executes: a first operation that supplies the second conductive layer with the write pass voltage and supplies a third conductive layer which is one of the plurality of first conductive layers with the program voltage; and a second operation that supplies the second conductive layer with a verify voltage and supplies the third conductive layer with a voltage.

Abstract: Provided is a micro head having a simple structure and yet entailing extremely little backlash. A micro head includes a spindle, a sleeve, a thimble, a backlash absorbing member, and a collar, wherein the cylindrical backlash absorbing member is fixed to the sleeve in a state where the spindle is inserted at a position in the sleeve.

Abstract: A silicon carbide porous body contains ?-SiC particles, Si particles, and metal silicide particles. The maximum particle diameter of the ?-SIC particles is not smaller than 15 ?m. The content of the Si particles is not lower than 10 mass %. The maximum particle diameter of the Si particles is not larger than 40 ?m. Further, an oxide coating film having a thickness not smaller than 0.01 ?m and not larger than 5 ?m is provided on surfaces of the Si particles.

Abstract: A composite sintered body contains a silicon phase which is a main phase, a cordierite phase, and an amorphous phase containing Si. Further, the volume resistivity thereof at a room temperature is not lower than 0.1?·cm and not higher than 2.5?·cm.

Abstract: This disk brake includes an attachment member that has support portions movably supporting a pair of brake pads, and a caliper that pressurizes the brake pads against a disk. The attachment member has outer circumferential frame portions, a coupling beam portion, and support main body portions. The outer circumferential frame portions extend in a disk circumferential direction so as to cover the disk while straddling the disk. The coupling beam portion couples the support portions to each other. The support main body portions form the support portions. The outer frame constituting portions constitute the outer frames of the support main body portions. Positions of disk-axially outward side end surfaces in a disk axial direction are the same as positions of the disk-axially outward side end surfaces of the caliper or on sides outward in the disk axial direction.

Abstract: A stage mechanism includes a feed screw, a fixed stage having a space portion incorporating the feed screw, a movable stage, and a backlash absorbing portion. The feed screw has a first end portion and a second end portion. The stage mechanism further includes a deviation preventing portion preventing the feed screw from deviating in a direction toward the first end portion and a pressing force adjusting portion adjusting the pressing force by which the feed screw is pressed in a direction from the second end portion side to the first end portion. The deviation preventing portion is in contact with a wall of the space portion on the first end portion side. The pressing force adjusting portion is in line contact with and presses the second end portion.

Abstract: A honeycomb structure has a plurality of cells formed by a plurality of partition walls. The partition walls are formed of a porous material composed predominantly of cordierite. Each partition wall includes surface layer portions having a porosity of 50% or more and an inside portion having a porosity of 50% or more, the surface layer portions being portions ranging respectively from opposite surfaces to a depth corresponding to 25% of the thickness of the partition wall, and the inside portion being the other portion. The surface layer portions and the inside portion both include pores having axial pore widths of less than 30 ?m and pores having axial pore widths of 30 ?m or more. A mean axial pore width in the surface layer portions is smaller than a mean axial pore width in the inside portion.

Abstract: A joined body includes a junction target, an underlying layer, an electrode part, and a fixed layer. The conductive underlying layer is fixed on a surface of the junction target. The electrode part is fixed on the underlying layer. The conductive fixed layer is fixed on the underlying layer with the electrode part interposed therebetween. Respective porosities of the underlying layer and the fixed layer are each not higher than 10%.

Abstract: There is provided a flight management system for managing a flight plan of flying objects that fly among ports.

Abstract: A method of adjusting operating conditions includes: a substrate; first conductive layers; a first semiconductor layers facing the first conductive layers; a second semiconductor layer connected to the first semiconductor layers; and an electric charge accumulating layer disposed between the first conductive layers and the first semiconductor layers. At a predetermined timing of a program operation, the second conductive layer which is one of the first conductive layers is supplied with a program voltage or a write pass voltage. The method executes: a first operation that supplies the second conductive layer with the write pass voltage and supplies a third conductive layer which is one of the plurality of first conductive layers with the program voltage; and a second operation that supplies the second conductive layer with a verify voltage and supplies the third conductive layer with a voltage.

Abstract: A microplate reader includes a plurality of sets of: a light emitting portion disposed on one side of a microplate and corresponding to one well of the microplate; a light receiving portion disposed on an opposite side to the light emitting portion across the microplate and corresponding to one well of the microplate; and a light receiving light guide path disposed between the light receiving portion and the microplate and guiding light emitted from the light emitting portion and passing through a sample contained in the well to the light receiving portion. The microplate reader further includes a light guiding section configured to enclose a plurality of the light receiving light guide paths by an enclosure member made of a pigment-containing resin containing a pigment having a light-absorbing property. Light emitted from one light emitting portion passing through one light receiving light guide path and reaching one light receiving portion.

Abstract: According to one embodiment, a memory system includes: a memory device including a memory cell transistor; and a controller configured to make first data inaccessible from an outside of the memory system without erasing the first data, and increase a threshold voltage of the memory cell transistor, before determining to write data into the memory cell transistor. The controller is further configured to decrease, after determining to write second data into the memory cell transistor, the threshold voltage of the memory cell transistor to bring the memory cell transistor into an erase state; and write, after bringing the memory cell transistor into the erase state, the second data into the memory cell transistor.

Abstract: A power storage apparatus has a case accommodating an electrode assembly, and a release valve present in the wall of the case. The electrode assembly includes electrodes. A shielding member is arranged between the inner surface of the wall and the end surface of the electrode assembly. A point located in a center of the case in a front view of the case taken in the stacking direction of the electrodes and located in a center of a dimension of the electrode assembly in the stacking direction is a center point, and a region surrounded by a plane connecting the center point and a contour of the pressure release valve at a shortest distance is a three-dimensional region. The shielding member includes a shielding portion that entirely covers a cross section of the three-dimensional region along the end face of the electrode assembly.